Pharmacokinetics of single-dose oral pregabalin administration in normal dogs

Veterinary Anaesthesia and Analgesia

Volumn 36, Issue 6, 2009, Pages 574-580

  Salazar, Veronica ^a   Dewey, Curtis W ^a   Schwark, Wayne ^a   Badgley, Britton L ^a   Gleed, Robin D ^a   Horne, William ^a   Ludders, John W ^a  

^a Department of Obstetrics Gynecology   (United States)

Author keywords

Analgesia; Anticonvulsant; Dog; Oral; Pharmacokinetics; Pregabalin

Indexed keywords

ANIMALIA; CANIS FAMILIARIS;

EID: 70350158207     PISSN: 14672987     EISSN: 14672995     Source Type: Journal    
DOI: 10.1111/j.1467-2995.2009.00486.x     Document Type: Article

References (42)

1. Al-Tahan F, Frey HH (1985) Absorption kinetics and bioavailability of phenobarbital after oral administration to dogs. J Vet Pharmacol Ther 8, 205 207.
2. Arroyo S, Anhut H, Kugler AR et al. (2004) Pregabalin add-on treatment: a randomized, double-blind, placebo-controlled, dose-response study in adults with partial seizures. Epilepsia 45, 20 27.
3. Belliotti TR, Capiris T, Ekhato IV et al. (2005) Structure-activity relationships of pregabalin and analogues that target the alpha(2)-delta protein. J Med Chem 48, 2294 2307.
4. Ben-Menachem E (2004) Pregabalin pharmacology and its relevance to clinical practice. Epilepsia 45, 13 18.
5. Ben-Menachem E, Kugler AR (2005) Pregabalin and epilepsy. In : Treatment of Epilepsy (2nd edn). Shorvon S, Fish D, Dodson W (eds). Blackwell Publishing Ltd, Oxford, UK. pp. 469 499.
6. Berry D, Millington C (2005) Analysis of pregabalin at therapeutic concentrations in human plasma/serum by reversed-phase HPLC. Ther Drug Monit 27, 451 456.
7. Beydoun A, Uthman BM, Kugler AR et al. (2005) Safety and efficacy of two pregabalin regimens for add-on treatment of partial epilepsy. Neurology 4, 475 480.
8. Bialer M, Johannessen SI, Kupferberg HJ et al. (2004) Progress report on new antiepileptic drugs: a summary of the Seventh Eilat Conference (EILAT VII). Epilepsy Res 261, 1 48.
9. Bockbrader HN, Hunt T, Strand JC et al. (2000) Pregabalin pharmacokinetics and safety in healthy volunteers: results from two phase 1 studies. Neurology 54, (Suppl. 3), A421.
10. Bockbrader HN, Wesche DL (2004) Pharmacokinetic profile of pregabalin: results of a series of studies. Presented at the Annual Meeting of the American Psychiatric Association (abstract).
11. Bockbrader HN, Burger PJ, Corrigan BW (2001a) Population pharmacokinetic (PK) analysis of pregabalin (PGB) in adult patients with refractory partial seizures. Epilepsia 42, 84 (abstract).
12. Bockbrader HN, Burger PJ, Kugler AR et al. (2001b) Population pharmacokinetic (PK) analyses of commonly prescribed antiepileptic drugs (AEDs) coadministered with pregabalin (PGB) in adult patients with refractory partial seizures. Epilepsia 42, 84 (abstract).
13. Bockbrader HN, Strand JC, Wesche DL (2001c) Drug interaction studies of pregabalin (CI-1008, PGB) in patients with epilepsy maintained on either valproate (VPA), lamotrigine (LTG), phenytoin (PHT), or carbamazepine (CBZ). Epilepsia 42, 86 (abstract).
14. Bryans JS, Wustrow DJ (1999) 3-substituted GABA analogs with central nervous system activity: a review. Med Res Rev 19, 149 177.
15. Busch JA, Strand JC, Posvar EL et al. (1998) Pregabalin (CI-1008) single-dose pharmacokinetics and safety/tolerance in healthy subjects after oral administration of pregabalin solution or capsule doses. Epilepsia 39, 58 (abstract).
16. Corrigan BW, Pool WF, Posvar EL (2001) Metabolic disposition of pregabalin in healthy volunteers. Clin Pharmacol Ther 69, 18 (abstract).
17. Corrigan BW, Burger PJ, Bockbrader HN (2002) Population pharmacokinetics of pregabalin in healthy volunteers, renally impaired patients and patients with chronic pain. J Pain 3, 47.
18. Cunningham MO, Woodhall GL, Thompson SE et al. (2004) Dual effects of gabapentin and pregabalin on glutamate release at rat entorhinal synapses in vitro. Eur J Neurosci 20, 1566 1576.
19. Doggrell SA (2005) Pregabalin or morphine and gabapentin for neuropathic pain. Expert Opin Pharmacother 6, 2535 2539.
20. Dooley DJ, Donovan CM, Pugsley TA (2000a) Stimulus-dependent modulation of [(3)H]norepinephrine release from rat neocortical slices by gabapentin and pregabalin. J Pharmacol Exp Ther 295, 1086 1093.
21. Dooley DJ, Mieske CA, Borosky SA (2000b) Inhibition of K(+)-evoked glutamate release from rat neocortical and hippocampal slices by gabapentin. Neurosci Lett 280, 107 110.
22. Dooley DJ, Donovan CM, Meder WP et al. (2002) Preferential action of gabapentin and pregabalin at P/Q-type voltage-sensitive calcium channels: inhibition of K+-evoked [3H]-norepinephrine release from rat neocortical slices. Synapse 45, 171 190.
23. Dworkin RH, Corbin AE, Young JP et al. (2003) Pregabalin for the treatment of postherpetic neuralgia: a randomized, placebo-controlled trial. Neurology 60, 1274 1283.
24. Elger CE, Brodie MJ, Anhut H et al. (2005) Pregabalin add-on treatment in patients with partial seizures: a novel evaluation of flexible-dose and fixed-dose treatment in a double-blind, placebo-controlled study. Epilepsia 46, 1926 1936.
25. Farid NA (1979) Fluorescamine use in high-performance liquid chromatographic determination of aminocaproic acid in serum. J Pharm Sci 68, 249 252.
26. Fink K, Meder W, Dooley DJ et al. (2000) Inhibition of neuronal Ca(2+) influx by gabapentin and subsequent reduction of neurotransmitter release from rat neocortical slices. Br J Pharmacol 130, 900 906.
27. Fink K, Dooley DJ, Meder WP et al. (2002) Inhibition of neuronal Ca(2+) influx by gabapentin and pregabalin in the human neocortex. Neuropharmacology 42, 229 236.
28. French JA, Kugler AR, Robbins JL et al. (2003) Dose-response trial of pregabalin adjunctive therapy in patients with partial seizures. Neurology 60, 1631 1637.
29. Freynhagen R, Strojek K, Griesing T et al. (2005) Efficacy of pregabalin in neuropathic pain evaluated in a 12-week, randomised, double-blind, multicentre, placebo-controlled trial of flexible- and fixed-dose regimens. Pain 115, 254 263.
30. Govendir M, Perkins M, Malik R (2005) Improving seizure control in dogs with refractory epilepsy using gabapentin as an adjunctive agent. Aust Vet J 83, 602 608.
31. Hill DR, Suman-Chauhan N, Woodruff GN (1993) Localization of [3H]gabapentin to a novel site in rat brain: autoradiographic studies. Eur J Pharmacol 244, 303 309.
32. Kugler AR, Robbins JL, Strand JC (2002) Pregabalin overview: a novel CNS-active compound with anticonvulsant activity. Poster presented at the annual meeting of the American Epilepsy Society, Seattle, WA, December 6-11.
33. Lesser H, Sharma U, LaMoreaux L et al. (2004) Pregabalin relieves symptoms of painful diabetic neuropathy: a randomized controlled trial. Neurology 63, 2104 2110. (Pubitemid 39636259)
34. Maneuf YP, Hughes J, McKnight AT (2001) Gabapentin inhibits the substance P-facilitated K(+)-evoked release of [(3)H]glutamate from rat caudal trigeminal nucleus slices. Pain 93, 191 196.
35. Marais E, Klugbauer N, Hofmann F (2001) Calcium channel alpha(2)delta subunits-structure and Gabapentin binding. Mol Pharmacol 59, 1243 1248.
36. Pande AC, Crockatt JG, Feltner DE et al. (2003) Pregabalin in generalized anxiety disorder: a placebo-controlled trial. Am J Psychiatry 160, 533 540.
37. Platt SR, Adams V, Garosi LS et al. (2006) Treatment with gabapentin of 11 dogs with refractory idiopathic epilepsy. Vet Rec 159, 881 884.
38. Randinitis EJ, Posvar EL, Alvey CW et al. (2003) Pharmacokinetics of pregabalin in subjects with various degrees of renal function. J Clin Pharmacol 43, 277 283.
39. Richter RW, Portenoy R, Sharma U et al. (2005) Relief of painful diabetic peripheral neuropathy with pregabalin: a randomized, placebo-controlled trial. J Pain 6, 253 260.
40. Rickels K, Pollack MH, Feltner DE et al. (2005) Pregabalin for treatment of generalized anxiety disorder: a 4-week, multicenter, double-blind, placebo-controlled trial of pregabalin and alprazolam. Arch Gen Psychiatry 62, 1022 1030.
41. Rosenstock J, Tuchman M, LaMoreaux L et al. (2004) Pregabalin for the treatment of painful diabetic peripheral neuropathy: a double-blind, placebo-controlled trial. Pain 110, 628 638.
42. Sabatowski R, Galvez R, Cherry DA et al. (2004) Pregabalin reduces pain and improves sleep and mood disturbances in patients with post-herpetic neuralgia: results of a randomised, placebo-controlled clinical trial. Pain 109, 26 35.