Clinical Doppler ultrasound for the assessment of plaque ulceration in the stenosed carotid bifurcation by detection of distal turbulence intensity: A matched model study

European Radiology

Volumn 19, Issue 11, 2009, Pages 2739-2749

  Wong, Emily Y ^a,b   Nikolov, Hristo N ^a   Thorne, Meghan L ^a,b   Poepping, Tamie L ^b   Rankin, Richard N ^b   Holdsworth, David W ^a,b  

^a ROBARTS RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

Carotid artery; Doppler ultrasound; Flow models; Plaque ulceration; Turbulence intensity

Indexed keywords

ARTICLE; BLOOD FLOW VELOCITY; CAROTID ARTERY BIFURCATION; CAROTID ARTERY OBSTRUCTION; CONTROLLED STUDY; DIASTOLE; DOPPLER ECHOGRAPHY; HEART CYCLE; LAMINAR FLOW; MATHEMATICAL MODEL; PHANTOM; PLAQUE ULCERATION; PRIORITY JOURNAL; SYSTOLE; TURBULENT FLOW; ULCER;

CAROTID ARTERY, INTERNAL; CAROTID STENOSIS; COMPUTER SIMULATION; CONSTRICTION, PATHOLOGIC; HEMODYNAMICS; HUMANS; IMAGING, THREE-DIMENSIONAL; MODELS, CARDIOVASCULAR; PHANTOMS, IMAGING; REPRODUCIBILITY OF RESULTS; THROMBOEMBOLISM; ULTRASONOGRAPHY, DOPPLER;

EID: 70350136259     PISSN: 09387994     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00330-009-1457-8     Document Type: Article

References (40)

1. Grant EG, Benson CB, Moneta GL et al (2003) Carotid artery stenosis: grayscale and Doppler ultrasound diagnosis - Society of Radiologists in Ultrasound consensus conference. Ultrasound Q 19:190-198
2. Wardlaw JM, Chappell FM, Best JJ et al (2006) Non-invasive imaging compared with intra-arterial angiography in the diagnosis of symptomatic carotid stenosis: A meta-analysis. Lancet 367:1503-1512
3. Hankey GJ (1999) Stroke prediction and prevention by carotid endarterectomy: Keep an eye on the doughnut and not just the hole. Cerebrovasc Dis 9:345-350
4. Eliasziw M, Streifler JY, Fox AJ et al (1994) Significance of plaque ulceration in symptomatic patients with high-grade carotid stenosis. North American Symptomatic Carotid Endarterectomy Trial. Stroke 25:304-308
5. Sitzer M, Muller W, Siebler M et al (1995) Plaque ulceration and lumen thrombus are the main sources of cerebral microemboli in high-grade internal carotid artery stenosis. Stroke 26:1231-1233
6. Orlandi G, Parenti G, Landucci Pellegrini L et al (1999) Plaque surface and microembolic signals in moderate carotid stenosis. Ital J Neurol Sci 20:179-182
7. Motomiya M, Karino T (1984) Flow patterns in the human carotid artery bifurcation. Stroke 15:50-56
8. Birchall D, Zaman A, Hacker J et al (2006) Analysis of haemodynamic disturbance in the atherosclerotic carotid artery using computational fluid dynamics. Eur Radiol 16:1074-1083
9. Imbesi SG, Kerber CW (1998) Why do ulcerated atherosclerotic carotid artery plaques embolize? A flow dynamics study. AJNR Am J Neuroradiol 19:761-766
10. Mustard JF, Murphy EA, Rowsell HC et al (1962) Factors influencing thrombus formation in vivo. Am J Med 33:621-647
11. Sakariassen KS, Holme PA, Orvim U et al (1998) Shear-induced platelet activation and platelet microparticle formation in native human blood. Thromb Res 92:S33-S41
12. Stein PD, Sabbah HN (1974) Measured turbulence and its effect on thrombus formation. Circ Res 35:608-614
13. Hoeks AP, Hennerici M, Reneman RS (1991) Spectral composition of Doppler signals. Ultrasound Med Biol 17:751-760
14. Sigel B, Gibson RJ, Amatneek KV et al (1970) A Doppler ultrasound method for distinguishing laminar from turbulent flow. A preliminary report. J Surg Res 10:221-224
15. Garbini JL, Forster FK, Jorgensen JE (1982) Measurement of fluid turbulence based on pulsed ultrasound techniques. Part 2. Experimental investigation. J Fluid Mech 118:471-505
16. Dunmire B, Pagel G, Beach KW et al (2001) Post stenotic flow disturbances in a steady flow model. In: SPIE-Int Soc Opt Eng, San Diego, pp 502-513
17. Evans DH, McDicken WN (2000) Doppler ultrasound: Physics, instrumentation and signal processing. Wiley, Chichester
18. Wong EY, Thorne ML, Nikolov HN et al (2008) Doppler ultrasound compatible plastic material for use in rigid flow models. Ultrasound Med Biol 34:1846-1856
19. Smith RF, Rutt BK, Fox AJ et al (1996) Geometric characterization of stenosed human carotid arteries. Acad Radiol 3:898-911
20. Fox AJ (1993) How to measure carotid stenosis. Radiology 186:316-318
21. Lovett JK, Gallagher PJ, Hands LJ et al (2004) Histological correlates of carotid plaque surface morphology on lumen contrast imaging. Circulation 110:2190-2197
22. Lovett JK, Rothwell PM (2003) Site of carotid plaque ulceration in relation to direction of blood flow: An angiographic and pathological study. Cerebrovasc Dis 16:369-375
23. Troyer A, Saloner D, Pan XM et al (2002) Major carotid plaque surface irregularities correlate with neurologic symptoms. J Vasc Surg 35:741-747
24. Saba L, Caddeo G, Sanfilippo R et al (2007) CT and ultrasound in the study of ulcerated carotid plaque compared with surgical results: potentialities and advantages of multidetector row CT angiography. AJNR Am J Neuroradiol 28:1061-1066
25. Rothwell PM, Gibson R, Warlow CP (2000) Interrelation between plaque surface morphology and degree of stenosis on carotid angiograms and the risk of ischemic stroke in patients with symptomatic carotid stenosis. On behalf of the European Carotid Surgery Trialists' Collaborative Group. Stroke 31:615-621
26. Poepping TL, Nikolov HN, Rankin RN et al (2002) An in vitro system for Doppler ultrasound flow studies in the stenosed carotid artery bifurcation. Ultrasound Med Biol 28:495-506
27. Ramnarine KV, Nassiri DK, Hoskins PR et al (1998) Validation of a new blood-mimicking fluid for use in Doppler flow test objects. Ultrasound Med Biol 24:451-459
28. Thorne ML, Poepping TL, Rankin RN et al (2008) Use of an ultrasound blood-mimicking fluid for Doppler investigations of turbulence in vitro. Ultrasound Med Biol 34:1163-1173
29. Holdsworth DW, Norley CJ, Frayne R et al (1999) Characterization of common carotid artery blood-flow waveforms in normal human subjects. Physiol Meas 20:219-240
30. Frayne R, Holdsworth DW, Gowman LM et al (1992) Computer-controlled flow simulator for MR flow studies. J Magn Reson Imaging 2:605-612
31. Hoskins PR (1999) A review of the measurement of blood velocity and related quantities using Doppler ultrasound. Proc Inst Mech Eng [H], J Eng Med 213:391-400
32. Lesniak B, Kaluzynski K, Liepsch D et al (2002) The discrimination of stenosed carotid bifurcation models with smooth and irregular plaque surface. Part I. Laser and ultrasonic Doppler flow studies. Med Eng Phys 24:309-318
33. Benetos A, Waeber B, Izzo J et al (2002) Influence of age, risk factors, and cardiovascular and renal disease on arterial stiffness: Clinical applications. Am J Hypertens 15:1101-1108
34. Hansen F, Mangell P, Sonesson B et al (1995) Diameter and compliance in the human common carotid artery - variations with age and sex. Ultrasound Med Biol 21:1-9
35. Perktold K, Rappitsch G (1995) Computer simulation of local blood flow and vessel mechanics in a compliant carotid artery bifurcation model. J Biomech 28:845-856
36. Dewey CF (1979) Fluid mechanics of arterial flow. In: Wolf W, Werthessen NT (eds) Dynamics of arterial flow. Adv Exp Med Biol 115:55-103
37. Raz S, Einav S, Alemu Y et al (2007) DPIV prediction of flow induced platelet activation - comparison to numerical predictions. Ann Biomed Eng 35:493-504
38. Dyverfeldt P, Sigfridsson A, Kvitting JP et al (2006) Quantification of intravoxel velocity standard deviation and turbulence intensity by generalizing phase-contrast MRI. Magn Reson Med 56:850-858
39. Schulz UG, Rothwell PM (2001) Major variation in carotid bifurcation anatomy: A possible risk factor for plaque development? Stroke 32:2522-2529
40. Younis HF, Kaazempur-Mofrad MR, Chan RC et al (2004) Hemodynamics and wall mechanics in human carotid bifurcation and its consequences for atherogenesis: Investigation of inter-individual variation. Biomech Model Mechanobiol 3:17-32