Use of an Ultrasound Blood-Mimicking Fluid for Doppler Investigations of Turbulence In Vitro

Ultrasound in Medicine and Biology

Volumn 34, Issue 7, 2008, Pages 1163-1173

  Thorne, Meghan L ^a,b   Poepping, Tamie L ^b   Rankin, Richard N ^b   Steinman, David A ^c   Holdsworth, David W ^a,b  

^a ROBARTS RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

Backscattered power; Blood flow velocity; Blood mimicking fluid; Doppler ultrasound; Grid; In vitro modeling; Orifice; Turbulence intensity

Indexed keywords

ACOUSTIC WAVES; BLOOD; FLOW RATE; GLYCEROL; NON NEWTONIAN FLOW; REUSABILITY; ULTRASONICS;

BACKSCATTERED POWER; BLOOD FLOW VELOCITY; BLOOD-MIMICKING FLUID; DOPPLER; DOPPLER STUDIES; DOPPLER ULTRASOUND; GRID; IN VITRO MODELING; IN VITRO TESTING; IN-VITRO; ORIFICE; PHYSIOLOGICAL FLOW; TURBULENCE INTENSITIES; TURBULENCE INTENSITY; TURBULENT PATTERNS; ULTRASOUND PROPERTIES; WORKING FLUIDS;

TURBULENCE;

BLOOD SUBSTITUTE; GLYCEROL; ULTRASOUND BLOOD MIMICKING FLUID; WATER;

ARTICLE; BLOOD FLOW VELOCITY; BLOOD FLOWMETRY; COMPUTATIONAL FLUID DYNAMICS; CONSTRAINED JET TURBULENCE; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; DOPPLER FLOWMETRY; ERYTHROCYTE; FLOW MEASUREMENT; FLOW RATE; GRID GENERATED TURBULENCE; IN VITRO STUDY; NONHUMAN; PHYSICOCHEMICAL MODEL; PRIORITY JOURNAL; STENOSIS; TECHNICAL AID; THROMBOEMBOLISM; TURBULENT FLOW;

BLOOD; BLOOD FLOW VELOCITY; BLOOD SUBSTITUTES; HEMORHEOLOGY; HUMANS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; PHANTOMS, IMAGING; ULTRASONOGRAPHY, DOPPLER, COLOR;

EID: 45949090720     PISSN: 03015629     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ultrasmedbio.2007.12.014     Document Type: Article

References (56)

1. Adam D.R., and Burstein P. Vascular imaging by ultrasound: 3D reconstruction of flow velocity fields for endothelial shear stress calculation. Adv Exp Med Biol (1997) 430177-430185
2. Banks J., and Bressloff N.W. Turbulence modeling in three-dimensional stenosed arterial bifurcations. J Biomech Eng 129 (2007) 40-50
3. Bascom P.A., Cobbold R.S., Routh H.F., and Johnston K.W. On the Doppler signal from a steady flow asymmetrical stenosis model: Effects of turbulence. Ultrasound Med Biol 19 (1993) 197-210
4. Bascom P.A., Johnston K.W., Cobbold R.S., and Ojha M. Relation of the flow field distal to a moderate stenosis to the Doppler power. Ultrasound Med Biol 23 (1997) 25-39
5. Batchelor G.K. Introduction to fluid dynamics (1967), Cambridge University press, Edinburgh
6. Bluestein D., Li Y.M., and Krukenkamp I.B. Free emboli formation in the wake of bi-leaflet mechanical heart valves and the effects of implantation techniques. J Biomech 35 (2002) 1533-1540
7. Bluestein D., Rambod E., and Gharib M. Vortex shedding as a mechanism for free emboli formation in mechanical heart valves. J Biomech Eng 122 (2000) 125-134
8. Bradshaw P. An introduction to turbulence and its measurement (1971), Oxford: Pergamon Press
9. Bruneau C.H., Greffier O., and Kellay H. Numerical study of grid turbulence in two dimensions and comparison with experiments on turbulent soap films. Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics 60 (1999) R1162-R1165
10. Bruneau C.H., and Kellay H. Experiments and direct numerical simulations of two-dimensional turbulence. Phys Rev E Stat Nonlin Soft Matter Phys 71 (2005) 046305
11. Casty M., and Giddens D.P. 25 + 1 channel pulsed ultrasound Doppler velocity meter for quantitative flow measurements and turbulence analysis. Ultrasound Med Biol 10 (1984) 161-172
12. Cloutier G., Allard L., and Durand L.G. Changes in ultrasonic Doppler backscattered power downstream of concentric and eccentric stenoses under pulsatile flow. Ultrasound Med Biol 21 (1995) 59-70
13. Cloutier G., Allard L., and Durand L.G. Characterization of blood flow turbulence with pulsed-wave and power Doppler ultrasound imaging. J Biomech Eng 118 (1996) 318-325
14. Cloutier G., and Shung K.K. Cyclic variation of the power of ultrasonic Doppler signals backscattered by polystyrene microspheres and porcine erythrocyte suspensions. IEEE Trans Biomed Eng 40 (1993) 953-962
15. Evans A.J., Blinder R.A., Herfkens R.J., Spritzer C.E., Kuethe D.O., Fram E.K., and Hedlund L.W. Effects of turbulence on signal intensity in gradient echo images. Invest Radiol 23 (1988) 512-518
16. Fei D.Y., Billian C., and Rittgers S.E. Flow dynamics in a stenosed carotid bifurcation model-Part I: Basic velocity measurements. Ultrasound Med Biol 14 (1988) 21-31
17. Felix R.W.J., Sigel B., Gibson R.J., Williams J., Popky G.L., Edelstein A.L., and Justin J.R. Pulsed Doppler ultrasound detection of flow disturbances in arteriosclerosis. J Clin Ultrasound 4 (1976) 275-282
18. Garth K.E., Carroll B.A., Sommer F.G., and Oppenheimer D.A. Duplex ultrasound scanning of the carotid arteries with velocity spectrum analysis. Radiology 147 (1983) 823-827
19. Ghalichi F., and Deng X. Turbulence detection in a stenosed artery bifurcation by numerical simulation of pulsatile blood flow using the low-Reynolds number turbulence model. Biorheology 40 (2003) 637-654
20. Hinze J.O. Turbulence: An introduction to its mechanism and theory (1959), McGraw-Hill Book Company Inc, New York
21. Holdsworth D.W., Rickey D.W., Drangova M., Miller D.J., and Fenster A. Computer-controlled positive displacement pump for physiological flow simulation. Med Biol Eng Comput 29 (1991) 565-570
22. Huang Z.J., Merkle C.L., Abdallah S., and Tarbell J.M. Numerical simulation of unsteady laminar flow through a tilting disk heart valve: Prediction of vortex shedding. J Biomech 27 (1994) 391-402
23. Isaaz K., Bruntz J.F., Da Costa A., Winninger D., Cerisier A., de Chillou C., Sadoul N., Lamaud M., Ethevenot G., and Aliot E. Noninvasive quantitation of blood flow turbulence in patients with aortic valve disease using online digital computer analysis of Doppler velocity data. J Am Soc Echocardiography 16 (2003) 965-974
24. Krabill K.A., Sung H.W., Tamura T., Chung K.J., Yoganathan A.P., and Sahn D.J. Factors influencing the structure and shape of stenotic and regurgitant jets: An in vitro investigation using Doppler color flow mapping and optical flow visualization. J Am Coll Cardiol 13 (1989) 1672-1681
25. Ku D.N. Blood flow in arteries. Annu Rev Fluid Mech 29 (1997) 399-434
26. Langhaar H.L. Steady flow in transition length of straight tube. J Appl Mech 9 (1942) A55-A58
27. Leask R.L., Johnston K.W., and Ojha M. In vitro hemodynamic evaluation of a Simon nitinol vena cava filter: Possible explanation of IVC occlusion. J Vasc Interv Radiol 12 (2001) 613-618
28. Liggett J.A. Fluid mechanics (1994), New York: McGraw-Hill, Inc
29. Liu H., Winoto S.H., and Shah D.A. Velocity measurements within confined turbulent jets: Application to cardiovalvular regurgitation. Ann Biomed Eng 25 (1997) 939-948
30. Mathieu JaS J. An introduction to turbulent flow (2000), Cambridge University Press, New York
31. May P., Gerbault O., Arrouvel C., Revol M., Servant J.M., and Vicaut E. Nonlinear analysis of arterial oscillated flow in experimental stenosis and microsurgical anastomosis. J Surg Res 99 (2001) 53-60
32. Meyer R.S., Deutsch S., Bachmann C.B., and Tarbell J.M. Laser Doppler velocimetry and flow visualization studies in the regurgitant leakage flow region of three mechanical mitral valves. Artif Organs 25 (2001) 292-299
33. Milnor W.R. Hemodynamics (1982), Williams and Wilkins, Baltimore MD
34. Modi V.J., and Akutsu T. On the hemodynamics of several prosthetic heart valves: In vitro study. Monogr Atheroscler (1990) 15125-15137
35. Poepping T.L., Nikolov H.N., Rankin R.N., Lee M., and Holdsworth D.W. An in vitro system for Doppler ultrasound flow studies in the stenosed carotid artery bifurcation. Ultrasound Med Biol 28 (2002) 495-506
36. Poepping T.L., Nikolov H.N., Thorne M.L., and Holdsworth D.W. A thin-walled carotid vessel phantom for Doppler ultrasound flow studies. Ultrasound Med Biol 30 (2004) 1067-1078
37. Ramnarine K.V., Nassiri D.K., Hoskins P.R., and Lubbers J. Validation of a new blood-mimicking fluid for use in Doppler flow test objects. Ultrasound Med Biol 24 (1998) 451-459
38. Rickey D.W., Rankin R., and Fenster A. A velocity evaluation phantom for colour and pulsed Doppler instruments. Ultrasound Med Biol 18 (1992) 479-494
39. Ryval J., Straatman A.G., and Steinman D.A. Two-equation turbulence modeling of pulsatile flow in a stenosed tube. J Biomech Eng 126 (2004) 625-635
40. Shung K.K., Cloutier G., and Lim C.C. The effects of hematocrit, shear rate, and turbulence on ultrasonic Doppler spectrum from blood. IEEE Trans Biomed Eng 39 (1992) 462-469
41. Shung K.K., Yuan Y.W., Fei D.Y., and Tarbell J.M. Effect of flow disturbance on ultrasonic backscatter from blood. J Acoust Soc Am 75 (1984) 1265-1272
42. Sigel B. A brief history of Doppler ultrasound in the diagnosis of peripheral vascular disease. Ultrasound Med Biol 24 (1998) 169-176
43. Sigel B., Gibson R.J., Amatneek K.V., Felix Jr. W.R., Edelstein A.L., and Popky G.L. A Doppler ultrasound method for distinguishing laminar from turbulent flow. A preliminary report. J Surg Res 10 (1970) 221-224
44. Smith R.F., Rutt B.K., Fox A.J., Rankin R.N., and Holdsworth D.W. Geometric characterization of stenosed human carotid arteries. Academic Radiology 3 (1996) 898-911
45. Stein P.D., and Sabbah H.N. Measured turbulence and its effect on thrombus formation. Circ Res 35 (1974) 608-614
46. Stein P.D., and Sabbah H.N. Turbulent blood flow in the ascending aorta of humans with normal and diseased aortic valves. Circ Res 39 (1976) 58-65
47. Stroud J.S., Berger S.A., and Saloner D. Numerical analysis of flow through a severely stenotic carotid artery bifurcation. J Biomech Eng 124 (2002) 9-20
48. Sugawara M., Hirai A., Seo Y., Miyajima Y., and Uchibori T. A method of measuring the peak flow rate and the regurgitant volume of regurgitation based on the characteristics of turbulent free jets. Front Med Biol Eng 3 (1991) 45-55
49. Sukumar R., Athavale M.M., Makhijani V.B., and Przekwas A.J. Application of computational fluid dynamics techniques to blood pumps. Artif Organs 20 (1996) 529-533
50. Varghese S.S., and Frankel S.H. Numerical modeling of pulsatile turbulent flow in stenotic vessels. J Biomech Eng 125 (2003) 445-460
51. Walburn F.J., Sabbah H.N., and Stein P.D. An experimental evaluation of the use of an ensemble average for the calculation of turbulence in pulsatile flow. Ann Biomed Eng 11 (1983) 385-399
52. Wang J., Yao H., Lim C.J., Zhao Y., Yeo T.J., and Hwang N.H. Computational fluid dynamics study of a protruded-hinge bileaflet mechanical heart valve. J Heart Valve Dis 10 (2001) 254-262 discussion 263
53. Wu S.J., Shung K.K., and Brasseur J.G. In situ measurements of Doppler power vs. flow turbulence intensity in red cell suspensions. Ultrasound Med Biol 24 (1998) 1009-1021
54. Yellin E.L. Laminar-turbulent transition process in pulsatile flow. Circ Res 19 (1966) 791-804
55. Yoganathan A.P., Cape E.G., Sung H.W., Williams F.P., and Jimoh A. Review of hydrodynamic principles for the cardiologist: Applications to the study of blood flow and jets by imaging techniques. J Am Coll Cardiol 12 (1988) 1344-1353
56. Yongchareon W., and Young D.F. Initiation of turbulence in models of arterial stenoses. J Biomech 12 (1979) 185-196