Polyunsaturated fatty acids inhibit PI3K activity in a yeast-based model system

Biotechnology Journal

Volumn 4, Issue 8, 2009, Pages 1190-1197

  Couplan, Elodie ^a,b,c,d   Le Cann, Marie ^a,b,c,d   Le Foll, Christelle ^b,e   Corporeau, Charlotte ^b,f   Blondell, Marc ^a,b,c,d   Delarue, Jacques ^b,e  

^a INSERM   (France)

^b FACULTÉ DE MÉDECINE ET DES SCIENCES DE LA SANTÉ   (France)

^c ETABLISSEMENT FRANÇAIS DU SANG   (France)

^d CHU MORVAN   (France)

^e BREST UNIVERSITY HOSPITAL   (France)

^f IFREMER   (France)

Author keywords

Arachidonic acid; Cancer; Long chain n 3 polyunsaturated fatty acids; Nutrition; PI3K inhibition

Indexed keywords

ANTITUMOR DRUGS; APOPTOSIS; ARACHIDONIC ACID; BISPHOSPHATES; CANCER; CATALYTIC SUBUNITS; CELLULAR CONTEXTS; ENVIRONMENTAL FACTORS; FISH OIL; LONG-CHAIN N-3 POLYUNSATURATED FATTY ACIDS; MODEL SYSTEM; N-3 FATTY ACIDS; OVER-EXPRESSION; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLINOSITOL 3-KINASE; PI3K INHIBITION; POLYUNSATURATED FATTY ACIDS; STEADY-STATE LEVEL; YEAST CELL;

CELL DEATH; CELL MEMBRANES; FATTY ACIDS; GROWTH KINETICS; MAMMALS; NUTRITION; TUMORS; YEAST;

ACIDS;

ARACHIDONIC ACID; DOCOSAHEXAENOIC ACID; ICOSAPENTAENOIC ACID; OMEGA 3 FATTY ACID; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 PHOSPHATE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B;

ARTICLE; CULTURE MEDIUM; ENZYME ACTIVITY; ENZYME INHIBITION; FUNGAL STRAIN; NONHUMAN; NUTRITIONAL STATUS; PRIORITY JOURNAL; PROTEIN EXPRESSION; YEAST;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ANTINEOPLASTIC AGENTS; ARACHIDONIC ACIDS; CATALYTIC DOMAIN; ENZYME INHIBITORS; FATTY ACIDS, UNSATURATED; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUCOSE; HUMANS; MUTATION; NEOPLASMS; NUTRITIONAL SCIENCES; PLASMIDS; SACCHAROMYCES CEREVISIAE;

MAMMALIA;

EID: 70350123019     PISSN: 18606768     EISSN: 18607314     Source Type: Journal    
DOI: 10.1002/biot.200800229     Document Type: Article

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