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Volumn 15, Issue 5, 2009, Pages 413-418

Aerosolized antibiotics in critically ill ventilated patients

Author keywords

Aerosolized antibiotics; Bacterial resistance; Ventilator associated pneumonia; Ventilator associated tracheobronchitis

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; ANTIBIOTIC AGENT; COLISTIN; GENTAMICIN;

EID: 70350103000     PISSN: 10705295     EISSN: 15317072     Source Type: Journal    
DOI: 10.1097/MCC.0b013e328330abcf     Document Type: Review
Times cited : (40)

References (34)
  • 1
    • 3442887705 scopus 로고    scopus 로고
    • The antibiotic pipeline
    • Wenzel RP. The antibiotic pipeline. NEJM 2004; 351:523-526.
    • (2004) NEJM , vol.351 , pp. 523-526
    • Wenzel, R.P.1
  • 2
    • 59449088862 scopus 로고    scopus 로고
    • Antibiotic resistant bugs in the 21st century a clinical super-challenge
    • A review of how bacterial antibiotic resistance continues to outpace our ability to develop new antibiotics. The mechanisms of resistance are detailed. This should be read by any practitioner who wants to treat infection responsibly
    • Arias CA, Murray BE. Antibiotic resistant bugs in the 21st century a clinical super-challenge. NEJM 2009; 360:439-443. A review of how bacterial antibiotic resistance continues to outpace our ability to develop new antibiotics. The mechanisms of resistance are detailed. This should be read by any practitioner who wants to treat infection responsibly.
    • (2009) NEJM , vol.360 , pp. 439-443
    • Arias, C.A.1    Murray, B.E.2
  • 3
    • 13644269309 scopus 로고    scopus 로고
    • Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia
    • American Thoracic Society/Infectious Disease Society of America
    • American Thoracic Society/Infectious Disease Society of America. Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am J Respir Crit Care Med 2005; 171:388-416.
    • (2005) Am J Respir Crit Care Med , vol.171 , pp. 388-416
  • 4
    • 0016634343 scopus 로고
    • Prevention of Gram-negative bacillary pneumonia using polymyxin aerosol as prophylaxis II. Effect on the incidence of pneumonia in seriously ill patients
    • Klick JM, Du Moulin GC, Hedley-Whyte J, et al. Prevention of Gram-negative bacillary pneumonia using polymyxin aerosol as prophylaxis II. Effect on the incidence of pneumonia in seriously ill patients. J Clin Invest 1975; 55:514-519.
    • (1975) J Clin Invest , vol.55 , pp. 514-519
    • Klick, J.M.1    Du Moulin, G.C.2    Hedley-Whyte, J.3
  • 5
    • 0016710474 scopus 로고
    • Aerosol polymyxin and pneumonia in seriously ill patients
    • Feeley TW, Du Moulin GC, Hedley-Whyte J, et al. Aerosol polymyxin and pneumonia in seriously ill patients. N Engl J Med 1975; 293:471-475.
    • (1975) N Engl J Med , vol.293 , pp. 471-475
    • Feeley, T.W.1    Du Moulin, G.C.2    Hedley-Whyte, J.3
  • 6
    • 0027287651 scopus 로고
    • Efficacy of aerosolized tobramycin in patients with cystic fibrosis
    • Ramsey BW, Dorkin HL, Eisemberg JD, et al. Efficacy of aerosolized tobramycin in patients with cystic fibrosis. N Engl J Med 1993; 328:1740-1746.
    • (1993) N Engl J Med , vol.328 , pp. 1740-1746
    • Ramsey, B.W.1    Dorkin, H.L.2    Eisemberg, J.D.3
  • 7
    • 0033531143 scopus 로고    scopus 로고
    • Intermittent administration of inhaled tobramycin in patients with cystic fibrosis
    • Ramsey BW, Pepe MS, Quan JM, et al. Intermittent administration of inhaled tobramycin in patients with cystic fibrosis. N Engl J Med 1999; 340:23-30.
    • (1999) N Engl J Med , vol.340 , pp. 23-30
    • Ramsey, B.W.1    Pepe, M.S.2    Quan, J.M.3
  • 8
    • 0037015541 scopus 로고    scopus 로고
    • Biofilms and antibiotic resistance
    • Prince A. Biofilms and antibiotic resistance. NEJM 2002; 347:1110-1111.
    • (2002) NEJM , vol.347 , pp. 1110-1111
    • Prince, A.1
  • 9
    • 33847218319 scopus 로고    scopus 로고
    • The Lon protease of Pseudomonas aeruginosa is induced by aminoglycosides and is involved in biofilm formation and motility
    • Marr AK, Overhage J, Bains M. The Lon protease of Pseudomonas aeruginosa is induced by aminoglycosides and is involved in biofilm formation and motility. Microbiology 2007; 153:474-482.
    • (2007) Microbiology , vol.153 , pp. 474-482
    • Marr, A.K.1    Overhage, J.2    Bains, M.3
  • 10
    • 38349081527 scopus 로고    scopus 로고
    • Guiding aerosol deposition in the lung
    • Coates AL. Guiding aerosol deposition in the lung. NEJM 2004; 358:304-305.
    • (2004) NEJM , vol.358 , pp. 304-305
    • Coates, A.L.1
  • 11
    • 42649097553 scopus 로고    scopus 로고
    • Aerosol delivery during mechanical ventilation: From basic techniques to new devices
    • The author reviewed the available devices for aerosolization during mechanical ventilation and the strategy for increasing the aerosol efficiency
    • Dhand R. Aerosol delivery during mechanical ventilation: from basic techniques to new devices. J Aerosol Med Pulm Drug Deliv 2008; 21:45-60. The author reviewed the available devices for aerosolization during mechanical ventilation and the strategy for increasing the aerosol efficiency.
    • (2008) J Aerosol Med Pulm Drug Deliv , vol.21 , pp. 45-60
    • Dhand, R.1
  • 12
    • 42649121348 scopus 로고    scopus 로고
    • How best to deliver aerosol medications to mechanically ventilated patients
    • In this study, the authors review the techniques of aerosolization, the factors that influenced nebulization efficiency and give the optimal strategy to increase aerosol delivery
    • Dhand R, Guntur VP. How best to deliver aerosol medications to mechanically ventilated patients. Clin Chest Med 2008; 29:277-296. In this study, the authors review the techniques of aerosolization, the factors that influenced nebulization efficiency and give the optimal strategy to increase aerosol delivery.
    • (2008) Clin Chest Med , vol.29 , pp. 277-296
    • Dhand, R.1    Guntur, V.P.2
  • 13
    • 33846309189 scopus 로고    scopus 로고
    • Effective inhaled drug administration to mechanically ventilated patients
    • Dhand R, Mercier E. Effective inhaled drug administration to mechanically ventilated patients. Expert Opin Drug Deliv 2007; 4:47-61.
    • (2007) Expert Opin Drug Deliv , vol.4 , pp. 47-61
    • Dhand, R.1    Mercier, E.2
  • 14
    • 38049107842 scopus 로고    scopus 로고
    • Pulmonary Drug Delivery System for inhalation therapy in mechanically ventilated patients
    • This article characterizes a new delivery system for patients on mechanical ventilation
    • Dhand R, Sohal H. Pulmonary Drug Delivery System for inhalation therapy in mechanically ventilated patients. Expert Rev Med Devices 2008; 5:9-18. This article characterizes a new delivery system for patients on mechanical ventilation.
    • (2008) Expert Rev Med Devices , vol.5 , pp. 9-18
    • Dhand, R.1    Sohal, H.2
  • 16
    • 4644310916 scopus 로고    scopus 로고
    • Aerosolized antibiotics in mechanically ventilated patients
    • Smaldone GC. Aerosolized antibiotics in mechanically ventilated patients. Resp Care 2004; 49:635-639.
    • (2004) Resp Care , vol.49 , pp. 635-639
    • Smaldone, G.C.1
  • 17
    • 0031975321 scopus 로고    scopus 로고
    • Aerosolizedantibiotics inmechanically ventilated patients: Delivery and response
    • Palmer LB, Smaldone GC, Simon S, et al.Aerosolizedantibiotics inmechanically ventilated patients: delivery and response. Crit Care Med 1998; 26:31-39.
    • (1998) Crit Care Med , vol.26 , pp. 31-39
    • Palmer, L.B.1    Smaldone, G.C.2    Simon, S.3
  • 18
    • 4444256217 scopus 로고    scopus 로고
    • Disposition of instilled versus nebulized tobramycin and imipenem in ventilated intensive care unit (ICU) patients
    • Badia JR, Soy D, Adrover M, et al. Disposition of instilled versus nebulized tobramycin and imipenem in ventilated intensive care unit (ICU) patients. J Antimicrob Chemother 2004; 54:508-514.
    • (2004) J Antimicrob Chemother , vol.54 , pp. 508-514
    • Badia, J.R.1    Soy, D.2    Adrover, M.3
  • 19
    • 63849255256 scopus 로고    scopus 로고
    • Amikacin aerosol achieves high tracheal aspirate concentrations in intubated mechanically ventilated patients with Gram-negative pneumonia: A pharmacokinetic study [abstract]
    • Niederman MS, Sanchez M, Corkery K, et al. Amikacin aerosol achieves high tracheal aspirate concentrations in intubated mechanically ventilated patients with Gram-negative pneumonia: a pharmacokinetic study [abstract]. Am J Respir Crit Care Med 2007; 175:A326.
    • (2007) Am J Respir Crit Care Med , vol.175
    • Niederman, M.S.1    Sanchez, M.2    Corkery, K.3
  • 20
    • 63849191327 scopus 로고    scopus 로고
    • NKTR-061 (inhaled amikacin) BID achieves high epithelial lining fluid concentrations in pneumonic portions of the lung [abstract]
    • Luyt CE, Clavel M, Guntapali K, et al. NKTR-061 (inhaled amikacin) BID achieves high epithelial lining fluid concentrations in pneumonic portions of the lung [abstract]. Am J Respir Crit Care Med 2008; 177:A530.
    • (2008) Am J Respir Crit Care Med , vol.177
    • Luyt, C.E.1    Clavel, M.2    Guntapali, K.3
  • 21
    • 63849261370 scopus 로고    scopus 로고
    • Systemic versus aerosolized delivery of vancomycin for MRSA: Concentrations in lungs and serum [abstract]
    • Zarrilli GM, Monteforte M, Baram D, et al. Systemic versus aerosolized delivery of vancomycin for MRSA: concentrations in lungs and serum [abstract]. Am J Respir Crit Care Med 2008; 177:A286.
    • (2008) Am J Respir Crit Care Med , vol.177
    • Zarrilli, G.M.1    Monteforte, M.2    Baram, D.3
  • 22
    • 34247551021 scopus 로고    scopus 로고
    • Administration of antibiotics via the respiratory tract for the prevention of ICU-acquired pneumonia: A meta-analysis of comparative trials
    • Falagas ME, Siempos II, Bliziotis IA, Michalopoulos A. Administration of antibiotics via the respiratory tract for the prevention of ICU-acquired pneumonia: a meta-analysis of comparative trials. Crit Care 2006; 10:R123.
    • (2006) Crit Care , vol.10
    • Falagas, M.E.1    Siempos, I.I.2    Bliziotis, I.A.3    Michalopoulos, A.4
  • 23
    • 36448980984 scopus 로고    scopus 로고
    • Administration of antimicrobials via the respiratory tract for the treatment of patients with nosocomial pneumonia: A meta-analysis
    • Ioannidou E, Siempos II, Falagas ME. Administration of antimicrobials via the respiratory tract for the treatment of patients with nosocomial pneumonia: a meta-analysis. JAC 2007; 60:1216-1226.
    • (2007) JAC , vol.60 , pp. 1216-1226
    • Ioannidou, E.1    Siempos, I.I.2    Falagas, M.E.3
  • 24
    • 15444377551 scopus 로고    scopus 로고
    • Use of colistin in the treatment of multiple drug-resistant Gram-negative infections
    • Berlana D, Llop JM, Fort E, et al. Use of colistin in the treatment of multiple drug-resistant Gram-negative infections. Am J Health Syst Pharm 2005;62:39-47.
    • (2005) Am J Health Syst Pharm , vol.62 , pp. 39-47
    • Berlana, D.1    Llop, J.M.2    Fort, E.3
  • 25
    • 23844502584 scopus 로고    scopus 로고
    • Nebulized colistin in the treatment of pneumonia due to multidrug-resistant Acinetobacter baumannii and Pseudomonas aeruginosa
    • Kwa AL, Loh C, Low JG, et al. Nebulized colistin in the treatment of pneumonia due to multidrug-resistant Acinetobacter baumannii and Pseudomonas aeruginosa. Clin Infect Dis 2005; 41:754-757.
    • (2005) Clin Infect Dis , vol.41 , pp. 754-757
    • Kwa, A.L.1    Loh, C.2    Low, J.G.3
  • 26
    • 0033909658 scopus 로고    scopus 로고
    • Treatment of nosocomial pneumonia and tracheobronchitis caused by multidrug-resistant Pseudomonas aeruginosa with aerosolized colistin
    • Hamer DH. Treatment of nosocomial pneumonia and tracheobronchitis caused by multidrug-resistant Pseudomonas aeruginosa with aerosolized colistin. Am J Respir Crit Care Med 2000; 162:328-330.
    • (2000) Am J Respir Crit Care Med , vol.162 , pp. 328-330
    • Hamer, D.H.1
  • 27
    • 38749095520 scopus 로고    scopus 로고
    • Aerosolized colistin as adjunctive treatment of ventilator-associated pneumonia due to multidrug-resistant Gram-negative bacteria: A prospective study
    • An interesting prospective study demonstrating that aerosolized antibiotics resulted in a good treatment response. The study did not however have a control group
    • Michalopoulos A, Fotakis D, Virtzili S, et al. Aerosolized colistin as adjunctive treatment of ventilator-associated pneumonia due to multidrug-resistant Gram-negative bacteria: a prospective study. Respir Med 2008; 102:407-412. An interesting prospective study demonstrating that aerosolized antibiotics resulted in a good treatment response. The study did not however have a control group.
    • (2008) Respir Med , vol.102 , pp. 407-412
    • Michalopoulos, A.1    Fotakis, D.2    Virtzili, S.3
  • 28
    • 33745910567 scopus 로고    scopus 로고
    • The use of intravenous and aerosolized polymyxins for the treatment of infections in critically ill patients: A review of the recent literature
    • Falagas ME, Kasiakou SK, Tsiodras S, Michalopoulos A. The use of intravenous and aerosolized polymyxins for the treatment of infections in critically ill patients: a review of the recent literature. Clin Med Res 2006; 4:138-146.
    • (2006) Clin Med Res , vol.4 , pp. 138-146
    • Falagas, M.E.1    Kasiakou, S.K.2    Tsiodras, S.3    Michalopoulos, A.4
  • 29
    • 40949139207 scopus 로고    scopus 로고
    • Acinetobacter infection
    • Important review of one of the most resistant bacteria in the ICU. It has rapidly developed resistance to almost all antibiotics except for the colistins. All ICU physicians need to be familiar with this organism
    • Munoz-Price LS, Weinstein RA. Acinetobacter infection. NEJM 2008;358:1271-1281. Important review of one of the most resistant bacteria in the ICU. It has rapidly developed resistance to almost all antibiotics except for the colistins. All ICU physicians need to be familiar with this organism.
    • (2008) NEJM , vol.358 , pp. 1271-1281
    • Munoz-Price, L.S.1    Weinstein, R.A.2
  • 30
    • 63849255256 scopus 로고    scopus 로고
    • Inhaled amikacin reduces IV antibiotic use in intubated mechanically ventilated patients [abstract]
    • Niederman MS, Chastre J, Corkery K, et al. Inhaled amikacin reduces IV antibiotic use in intubated mechanically ventilated patients [abstract]. Am J Respir Crit Care Med 2007; 175:A326.
    • (2007) Am J Respir Crit Care Med , vol.175
    • Niederman, M.S.1    Chastre, J.2    Corkery, K.3
  • 31
    • 47249146963 scopus 로고    scopus 로고
    • Aerosolized antibiotics and ventilator-associated tracheobronchitis in the intensive care unit
    • The authors randomized 43 patients with purulent tracheobronchitis and Gram stain-identified microorganisms to receive aerosolized antibiotics (vancomycin for Gram-positive and gentamicin for Gram-negative) or placebo. Their data showed that antibiotic aerosolization led to faster resolution of clinical signs of pneumonia than placebo, fewer subsequent VAP episodes, less bacterial resistance and use of systemic antibiotics and facilitated weaning from mechanical ventilation
    • Palmer LB, Smaldone GC, Chen JJ, et al. Aerosolized antibiotics and ventilator-associated tracheobronchitis in the intensive care unit. Crit Care Med 2008; 36:2008-2013. The authors randomized 43 patients with purulent tracheobronchitis and Gram stain-identified microorganisms to receive aerosolized antibiotics (vancomycin for Gram-positive and gentamicin for Gram-negative) or placebo. Their data showed that antibiotic aerosolization led to faster resolution of clinical signs of pneumonia than placebo, fewer subsequent VAP episodes, less bacterial resistance and use of systemic antibiotics and facilitated weaning from mechanical ventilation.
    • Crit Care Med , vol.2008 , Issue.36 , pp. 2008-2013
    • Palmer, L.B.1    Smaldone, G.C.2    Chen, J.J.3
  • 32
    • 70350109739 scopus 로고    scopus 로고
    • Aerosolized vancomycin for treatment of Gram-positive respiratory infection in mechanically ventilated patients
    • Palmer LB, Baram D, Gunther MS, et al. Aerosolized vancomycin for treatment of Gram-positive respiratory infection in mechanically ventilated patients. Am J Respir Crit Care 2003; 167:7; A604.
    • (2003) Am J Respir Crit Care , vol.167 , Issue.7
    • Palmer, L.B.1    Baram, D.2    Gunther, M.S.3
  • 33
    • 70350098579 scopus 로고    scopus 로고
    • Aerosolized antibiotics; effect on bacterial resistance in the ICU
    • Palmer LB, Baram D, Smaldone GC. Aerosolized antibiotics; effect on bacterial resistance in the ICU. Am J Respir Crit Care 2009; 179:A5950.
    • (2009) Am J Respir Crit Care , vol.179
    • Palmer, L.B.1    Baram, D.2    Smaldone, G.C.3
  • 34
    • 63849333572 scopus 로고    scopus 로고
    • Aerosolized antibiotics to treat ventilator-associated pneumonia
    • Detailed review of the recent data in the field of aerosolized therapy for treating respiratory infections in mechanically ventilated patients
    • Luyt C-E, Combes A, Nieszkowska A, et al. Aerosolized antibiotics to treat ventilator-associated pneumonia. Curr Op Infect Di 2009; 22:154-158. Detailed review of the recent data in the field of aerosolized therapy for treating respiratory infections in mechanically ventilated patients.
    • (2009) Curr Op Infect Di , vol.22 , pp. 154-158
    • Luyt, C-E.1    Combes, A.2    Nieszkowska, A.3


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