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The author reviewed the available devices for aerosolization during mechanical ventilation and the strategy for increasing the aerosol efficiency
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Dhand R. Aerosol delivery during mechanical ventilation: from basic techniques to new devices. J Aerosol Med Pulm Drug Deliv 2008; 21:45-60. The author reviewed the available devices for aerosolization during mechanical ventilation and the strategy for increasing the aerosol efficiency.
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Dhand R, Guntur VP. How best to deliver aerosol medications to mechanically ventilated patients. Clin Chest Med 2008; 29:277-296. In this study, the authors review the techniques of aerosolization, the factors that influenced nebulization efficiency and give the optimal strategy to increase aerosol delivery.
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This article characterizes a new delivery system for patients on mechanical ventilation
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Dhand R, Sohal H. Pulmonary Drug Delivery System for inhalation therapy in mechanically ventilated patients. Expert Rev Med Devices 2008; 5:9-18. This article characterizes a new delivery system for patients on mechanical ventilation.
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Amikacin aerosol achieves high tracheal aspirate concentrations in intubated mechanically ventilated patients with Gram-negative pneumonia: A pharmacokinetic study [abstract]
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Niederman MS, Sanchez M, Corkery K, et al. Amikacin aerosol achieves high tracheal aspirate concentrations in intubated mechanically ventilated patients with Gram-negative pneumonia: a pharmacokinetic study [abstract]. Am J Respir Crit Care Med 2007; 175:A326.
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NKTR-061 (inhaled amikacin) BID achieves high epithelial lining fluid concentrations in pneumonic portions of the lung [abstract]
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Luyt CE, Clavel M, Guntapali K, et al. NKTR-061 (inhaled amikacin) BID achieves high epithelial lining fluid concentrations in pneumonic portions of the lung [abstract]. Am J Respir Crit Care Med 2008; 177:A530.
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Zarrilli GM, Monteforte M, Baram D, et al. Systemic versus aerosolized delivery of vancomycin for MRSA: concentrations in lungs and serum [abstract]. Am J Respir Crit Care Med 2008; 177:A286.
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Aerosolized colistin as adjunctive treatment of ventilator-associated pneumonia due to multidrug-resistant Gram-negative bacteria: A prospective study
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An interesting prospective study demonstrating that aerosolized antibiotics resulted in a good treatment response. The study did not however have a control group
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Michalopoulos A, Fotakis D, Virtzili S, et al. Aerosolized colistin as adjunctive treatment of ventilator-associated pneumonia due to multidrug-resistant Gram-negative bacteria: a prospective study. Respir Med 2008; 102:407-412. An interesting prospective study demonstrating that aerosolized antibiotics resulted in a good treatment response. The study did not however have a control group.
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Respir Med
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Michalopoulos, A.1
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The use of intravenous and aerosolized polymyxins for the treatment of infections in critically ill patients: A review of the recent literature
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Falagas ME, Kasiakou SK, Tsiodras S, Michalopoulos A. The use of intravenous and aerosolized polymyxins for the treatment of infections in critically ill patients: a review of the recent literature. Clin Med Res 2006; 4:138-146.
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Michalopoulos, A.4
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29
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Acinetobacter infection
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Important review of one of the most resistant bacteria in the ICU. It has rapidly developed resistance to almost all antibiotics except for the colistins. All ICU physicians need to be familiar with this organism
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Munoz-Price LS, Weinstein RA. Acinetobacter infection. NEJM 2008;358:1271-1281. Important review of one of the most resistant bacteria in the ICU. It has rapidly developed resistance to almost all antibiotics except for the colistins. All ICU physicians need to be familiar with this organism.
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NEJM
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Munoz-Price, L.S.1
Weinstein, R.A.2
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Niederman MS, Chastre J, Corkery K, et al. Inhaled amikacin reduces IV antibiotic use in intubated mechanically ventilated patients [abstract]. Am J Respir Crit Care Med 2007; 175:A326.
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Corkery, K.3
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31
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The authors randomized 43 patients with purulent tracheobronchitis and Gram stain-identified microorganisms to receive aerosolized antibiotics (vancomycin for Gram-positive and gentamicin for Gram-negative) or placebo. Their data showed that antibiotic aerosolization led to faster resolution of clinical signs of pneumonia than placebo, fewer subsequent VAP episodes, less bacterial resistance and use of systemic antibiotics and facilitated weaning from mechanical ventilation
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Palmer LB, Smaldone GC, Chen JJ, et al. Aerosolized antibiotics and ventilator-associated tracheobronchitis in the intensive care unit. Crit Care Med 2008; 36:2008-2013. The authors randomized 43 patients with purulent tracheobronchitis and Gram stain-identified microorganisms to receive aerosolized antibiotics (vancomycin for Gram-positive and gentamicin for Gram-negative) or placebo. Their data showed that antibiotic aerosolization led to faster resolution of clinical signs of pneumonia than placebo, fewer subsequent VAP episodes, less bacterial resistance and use of systemic antibiotics and facilitated weaning from mechanical ventilation.
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Palmer, L.B.1
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63849333572
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Aerosolized antibiotics to treat ventilator-associated pneumonia
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Detailed review of the recent data in the field of aerosolized therapy for treating respiratory infections in mechanically ventilated patients
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Luyt C-E, Combes A, Nieszkowska A, et al. Aerosolized antibiotics to treat ventilator-associated pneumonia. Curr Op Infect Di 2009; 22:154-158. Detailed review of the recent data in the field of aerosolized therapy for treating respiratory infections in mechanically ventilated patients.
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Luyt, C-E.1
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Nieszkowska, A.3
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