Degradability of polymers for implantable biomedical devices

International Journal of Molecular Sciences

Volumn 10, Issue 9, 2009, Pages 4033-4065

  Lyu, SuPing ^a   Untereker, Darrel ^a  

^a MEDTRONIC INC   (United States)

Author keywords

Biodegradable polymers; Biological oxidation; Biostable polymers for implantable medical devices; Molecular mechanisms of hydrolysis; Physical biodegradation

Indexed keywords

POLY(ORTHO ESTER); POLYAMIDE; POLYANHYDRIDE; POLYCARBONATE; POLYESTER; POLYETHER; POLYIMIDE; POLYMER; POLYOLEFIN; POLYSULFONE; POLYURETHAN;

BIOCOMPATIBILITY; BIODEGRADABLE IMPLANT; BIODEGRADATION; COMPOSITE MATERIAL; DEVICE; HYDROLYSIS; IMPLANT; KINETICS; MEDICAL TECHNOLOGY; OXIDATION; POLYMERIZATION; REVIEW;

BIODEGRADABLE POLYMERS; BIOLOGICAL OXIDATION; BIOSTABLE POLYMERS FOR IMPLANTABLE MEDICAL DEVICES; MOLECULAR MECHANISMS OF HYDROLYSIS; PHYSICAL BIODEGRADATION;

ABSORBABLE IMPLANTS; BIOCOMPATIBLE MATERIALS; HUMANS; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; KINETICS; OXIDATION-REDUCTION; POLYMERS; REACTIVE OXYGEN SPECIES; SOLUTIONS;

EID: 70350069885     PISSN: None     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms10094033     Document Type: Review

References (28)

1. Heller, J.; Barr, J. Poly(ortho esters) - From concept to reality. Biomacromolecules 2004, 5, 1625-1632.
2. Kumar, N.; Langer, R.S.; Domb, A.J. Polyanhydrides: An overview. Adv. Drug Deliv. Rev. 2002, 16, 889-910.
3. Bourke, S.L.; Kohn. J. Polymers derived from the amino acid L-tyrosine: Polycarbonates, polyarylates and copolymers with poly(ethylene glycol). Adv. Drug Deliv. Rev. 2003, 55, 447-466. (Pubitemid 36423299)
4. Li, S. Hydrolytic degradation characteristics of aliphatic polyesters derived from lactic and glycolic acids. J. Biomed. Mater. Res. 1999, 48, 342-353. (Pubitemid 29242707)
5. Langer, R.; Tirrell, D.A. Designing materials for biology and medicine. Nature 2004, 428, 487-492.
6. Stokes, K.; McVenes, R.; Anderson, J.M. Polyurethane elastomer biostability. J. Biomater. Appl. 1995, 9, 321-354.
7. Yannas, I. Natural materials. In Biomaterials Science: An Introduction to Materials in Medicine, 2nd ed.; Ratner, B.D., Hoffman, A.S., Schoen, F.J., Lemons, J.E., Eds.; Elsevier: New York, NY, USA, 2004; pp. 127-137.
8. Lyu, S.P.; Schley, J.; Loy, B.; Lind, D.; Hobot, C.; Sparer, R.; Untereker, D. Kinetics and timetemperature equivalence of polymer degradation. Biomacromolecules 2007, 8, 2301-2310.
9. Eyal, A.M.; Canari, R. pH dependence of carboxylic and mineral acid extraction by amine-based extractants: Effects of pKa, amine basicaity, and diluent properties. Ind. Eng. Chem. Res. 1995, 34, 1789-1798.
10. van Nostrum, C.; Veldhuis, T.; Bos, G.; Henn, W. Hydrolytic degradation of oligo(lactic acid): A kinetic and mechanistic study. Polymer 2004, 45, 6779-6787. (Pubitemid 39207908)
11. Scearmur, T.; Clough, A.; Drew, D.; van der Grinten, M.; Jones, R. Temperature dependence of the mutual diffusion coefficient of deuterated polystyrene and poly(methyl methacrylate). Phys. Rev. E 1997, 55, R3840-R3843. (Pubitemid 127612724)
12. Denisov, E. Polymer oxidation and antioxidatant action. In Handbook of Polymer Degradation, 2nd ed.; Hamid, S.H., Eds.; Marfcel Dekker: New York, NY, USA, 2000; p. 392.
13. Zhang, J.; Lyu, S.P.; Pudil, B.; Luo, L.; Buckalew, A.; Schley, J.; Benz, M.; Hobot, M.; Sparer, R.; Untereker, D. Toughening and reinforcing biodegradable poly(lactide-co-glycolide) through processing. 2009, submitted for publication.
14. Li, S.; Garreau, H.; Vert, M. Structure-property relationships in the case of the degradation of massive aliphatic poly-(α-hydroxy acids) in aqueous media, part 1″ poly(DL-lactic acid). J. Mater. Sci. Mater. Med. 1990, 1, 123-130. (Pubitemid 21650015)
15. Grizzi, I.; Garreau, H.; Li, S.; Vert, M. Hydrolytic degradation of devices based on poly[m-lactic acid) size dependence. Biomaterials 1995, 16, 305-311.
16. Pitt, C.; Chasalow, F.; Hibionada, Y.; Klimas, D.; Schindler, A. Aliphatic polyesters. I. The degradation of poly(ε-caprolactone) in vivo. J. Appl. Polym. Sci. 1981, 26, 3779-3787. (Pubitemid 12454836)
17. Deng, M.; Zhou, J.; Chen, G.; Burkley, D.; Xu, Y.; Jamiolkowski, D.; Barbolt, T. Effect of load and temperature on in vitro degradation of poly(glycolide-co-L-lactide) multifilament braids. Biomaterials 2005, 26, 4327-4336. (Pubitemid 40430861)
18. von Burkersroda, F.; Sched, L.; Göpferich, A. Why degradable polymers undergo surface erosion or bulk erosion. Biomaterials 2003, 23, 4221-4231. (Pubitemid 34814991)
19. Lyu, S.P.; Sparer, R.; Untereker, D. Analytical solutions to mathematical models of the surface and bulk erosion of solid polymers. J. Polym. Sci., Part B: Polym. Phys. 2005, 43, 383-397. (Pubitemid 40206690)
20. Casas, J.; Zhao, Q.; Donovan, M.; Schroeder, P.; Stokes, K.; Untereker, D. In vitro modulation of macrophage phenotype and inhibition of polymer degradation by dexamethasone in a human macrophage/Fe/stress system. J. Biomed. Mater. Res. 1999, 46, 475-484. (Pubitemid 29327604)
21. George, G.; Celina, M. Homogeneous and heterogeneous oxidation of polypropylene. In Handbook of Polymer Degradation, 2nd ed.; Hamid, S., Ed.; Marcel and Decker: New York, NY, USA, 2000; p. 335.
22. Mikheev, Y.A.; Guseva, L.N.; Zaikov, G.E. New mechanisms of polymer degradation. In Handbook of Polymer Degradation, 2nd ed.; Hamid, S.H., Ed.; Marcel Dekker: New York, NY, USA, 2000; p. 392.
23. Odian, G. Principles of Polymerization, 3rd ed.; John Wiley & Sons: New York, NY, USA, 1991; p. 274.
24. Gugumus, F. Thermooxidative degradation of polyolefins in the solid state. Part 3: Heterogeneous oxidation model. Polym. Degrad. Stab. 1996, 52, 159-170. (Pubitemid 126373276)
25. Denisov, E. Polymer oxidation and antioxidatant action. In Handbook of Polymer Degradation, 2nd ed.; Hamid, S.H., Ed.; Marcel Dekker: New York, NY, USA, 2000; p. 393.
26. Lyu, S.; Schley, J.; Loy, B.; Luo, L.; Hobot, C.; Sparer, R.; Untereker, D.; Krzeszak, J. In vitro biostability evaluation of polyurethane composites in acidic, basic, oxidative, and neutral solutions. J. Biomed. Mater. Res. Part B: Appl. Biomater. 2008, 85B, 509-518. (Pubitemid 351600458)
27. 2 test system for in vitro evaluation of biodegradative stress cracking in polyurethane elastomers. J. Biomed. Mater. Res. 1995, 29, 467-475.
28. Ward, B.; Anderson, J.; McVenes, R.; Stokes, K. In vivo biostability of polysiloxane polyether polyurethanes: Resistance to biologic oxidation and stress cracking. J. Biomed. Mater. Res. A 2006, 77A, 580-589. (Pubitemid 47233583)