The potential therapeutic of siRNA eye drops in ocular diseases

Bioscience Hypotheses

Volumn 2, Issue 4, 2009, Pages 223-225

  Nie, Yuhong ^a   Pan, Zhujuan ^a,b   Wu, Kaili ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b First People's Hospital of Huanggang   (China)

Author keywords

Eye drop; RNA interference; siRNA

Indexed keywords

SMALL INTERFERING RNA;

ARTICLE; CONJUNCTIVA EPITHELIUM; CORNEA EPITHELIUM; DRUG EFFICACY; DRUG MECHANISM; DRUG SAFETY; EYE DISEASE; GENE EXPRESSION; GENE TARGETING; HUMAN; TEAR FILM;

ANIMALIA;

EID: 70350053418     PISSN: 17562392     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bihy.2009.04.003     Document Type: Article

References (14)

1. Elbashir S.M., Harborth J., Lendeckel W., Yalcin A., Weber K., and Tuschl T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411 6836 (2001) 494-498
2. Raoul C., Barker S.D., and Aebischer P. Viral-based modelling and correction of neurodegenerative diseases by RNA interference. Gene Ther 13 6 (2006) 487-495
3. Pai S.I., Lin Y.Y., Macaes B., Meneshian A., Hung C.F., and Wu T.C. Prospects of RNA interference therapy for cancer. Gene Ther 13 6 (2006) 464-477
4. Lau T.S., Li Y., Kameoka M., Ng T.B., and Wan D.C. Suppression of HIV replication using RNA interference against HIV-1 integrase. FEBS Lett 581 17 (2007) 3253-3259
5. Bhuyan P.K., Kariko K., Capodici J., Lubinski J., Hook L.M., Friedman H.M., et al. Short interfering RNA-mediated inhibition of herpes simplex virus type 1 gene expression and function during infection of human keratinocytes. J Virol 78 19 (2004) 10276-10281
6. Bitko V., Musiyenko A., Shulyayeva O., and Barik S. Inhibition of respiratory viruses by nasally administered siRNA. Nat Med 11 1 (2005) 50-55
7. Kim B., Tang Q.Q., Biswas P.S., Xu J., Schiffelers R.M., Xie F.Y., et al. Inhibition of ocular angiogenesis by siRNA targeting vascular endothelial growth factor pathway genes - therapeutic strategy for herpetic stromal keratitis. Am J Pathol 165 6 (2004) 2177-2185
8. Reich S.J., Fosnot J., Kuroki A., Tang W., Yang X., Maguire A.M., et al. Small interfering RNA (siRNA) targeting VEGF effectively inhibits ocular neovascularization in a mouse model. Mol Vis 9 (2003) 210-216
9. Jia R.B., Zhang P., Zhou Y.X., Song X., Liu H.Y., Wang L.Z., et al. VEGF-targeted RNA interference suppresses angiogenesis and tumor growth of retinoblastoma. Ophthalmic Res 39 2 (2007) 108-115
10. Nakamura H., Siddiqui S.S., Shen X., Malik A.B., Pulido J.S., Kumar N.M., et al. RNA interference targeting transforming growth factor-beta type II receptor suppresses ocular inflammation and fibrosis. Mol Vis 10 (2004) 703-711
11. Palliser D., Chowdhury D., Wang Q.Y., Lee S.J., Bronson R.T., Knipe D.M., et al. An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection. Nature 439 7072 (2006) 89-94
12. Toropainen E., Hornof M., Kaarniranta K., Johansson P., and Urtti A. Corneal epithelium as a platform for secretion of transgene products after transfection with liposomal gene eyedrops. J Gene Med 9 3 (2007) 208-216
13. Fulton A., Peters S.T., Perkins G.A., Jarosinski K.W., Damiani A., Brosnahan M., et al. Effective treatment of respiratory alphaherpesvirus infection using RNA interference. PLoS ONE 4 1 (2009) e4118
14. Fukuda M., Inoue A., Sasaki K., and Takahashi N. The effect of the corneal epithelium on the intraocular penetration of fluoroquinolone ophthalmic solution. Jpn J Ophthalmol 48 2 (2004) 93-96