RNA interference targeted to the conserved dimerization initiation site (DIS) of HIV-1 restricts virus escape mutation

Journal of Biochemistry

Volumn 146, Issue 4, 2009, Pages 481-489

  Sugiyama, Ryuichi ^a   Habu, Yuichiro ^a,c   Ohnari, Aki ^a   Miyano Kurosaki, Naoko ^a   Takaku, Hiroshi ^a,b  

^a Department of Life and Environmental Science ^*  (Japan)

^b CHIBA INSTITUTE OF TECHNOLOGY   (Japan)

^c Department of Ecosystem Science and Sustainability   (United States)

Author keywords

Combination therapy; HIV 1; Lentiviral vector; RNA interference; Virus escape mutation; Well conserved dimerization initiation site (DIS)

Indexed keywords

SHORT HAIRPIN RNA; UNCLASSIFIED DRUG; VIRION INFECTIVITY FACTOR; VIRUS PROTEIN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DIMERIZATION; DIMERIZATION INITIATION SITE; GENE LOCUS; GENE MUTATION; GENE TARGETING; GENE THERAPY; GENETIC CONSERVATION; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOID CELL LINE; MONOTHERAPY; NONHUMAN; RNA INTERFERENCE; VIRAL PHENOMENA AND FUNCTIONS; VIRUS ESCAPE; VIRUS INHIBITION; VIRUS MUTANT; VIRUS REPLICATION;

ANTI-HIV AGENTS; CELL LINE; CONSERVED SEQUENCE; DIMERIZATION; HIV-1; MUTAGENESIS; MUTATION; NUCLEIC ACID CONFORMATION; RNA INTERFERENCE; RNA, SMALL INTERFERING; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 70350045152     PISSN: 0021924X     EISSN: 17562651     Source Type: Journal    
DOI: 10.1093/jb/mvp093     Document Type: Article

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