Conformational landscape of the human immunodeficiency virus type 1 reverse transcriptase non-nucleoside inhibitor binding pocket: Lessons for inhibitor design from a cluster analysis of many crystal structures

Journal of Medicinal Chemistry

Volumn 52, Issue 20, 2009, Pages 6413-6420

  Paris, Kristina A ^a   Haq, Omar ^a   Felts, Anthony K ^a   Das, Kalyan ^a,b   Arnold, Eddy ^a,b   Levy, Ronald M ^a  

^a RUTGERS UNIVERSITY   (United States)

^b RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAPRAVIRINE; RILPIVIRINE; RNA DIRECTED DNA POLYMERASE;

ARTICLE; CLUSTER ANALYSIS; CRYSTAL STRUCTURE; DRUG BINDING; DRUG CONFORMATION; DRUG DESIGN; ENZYME INHIBITION;

BINDING SITES; CLUSTER ANALYSIS; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HIV REVERSE TRANSCRIPTASE; HIV-1; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NUCLEOSIDES; PROTEIN CONFORMATION; REVERSE TRANSCRIPTASE INHIBITORS;

EID: 70350043532     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm900854h     Document Type: Article

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