Role of lipoxygenases and lipoxin A4/annexin-1 receptor in gastric protection induced by 20% ethanol or sodium salicylate in rats

Pharmacology

Volumn 84, Issue 5, 2009, Pages 310-313

  Peskar, Brigitta M ^a   Ehrlich, Karlheinz ^a   Schuligoi, Rufina ^b   Peskar, Bernhard A ^b  

^a RUHR UNIVERSITY BOCHUM   (Germany)

^b MEDICAL UNIVERSITY OF GRAZ   (Austria)

Author keywords

Adaptive protection; Cyclooxygenase; Ethanol damage; Gastric mucosal damage; Ischemia reperfusion; Lipoxin A4 annexin 1 receptor; Lipoxygenase; Sodium salicylate

Indexed keywords

6,11 DIHYDRO 5 THIA 11 AZABENZO[A]FLUORENE; ALCOHOL; ARACHIDONATE 12 LIPOXYGENASE; ARACHIDONATE 5 LIPOXYGENASE; BAICALEIN; CELECOXIB; DEXAMETHASONE; LIPOXIN A; LIPOXIN RECEPTOR; LIPOXYGENASE; LIPOXYGENASE INHIBITOR; N [1 (4 BENZYLOXYPHENYL)ETHYL]ACETOHYDROXAMIC ACID; N TERT BUTOXYCARBONYLMETHIONYLLEUCYLPHENYLALANINE; PD 146176; PROSTAGLANDIN SYNTHASE; RECEPTOR BLOCKING AGENT; SALICYLATE SODIUM; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG DOSE INCREASE; DRUG EFFECT; ENZYME INHIBITION; FATTY ACID METABOLISM; ISCHEMIA; LOW DRUG DOSE; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; STOMACH MUCOSA; STOMACH PROTECTION;

ACETAMIDES; ANIMALS; ANNEXINS; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; DEXAMETHASONE; DRUG INTERACTIONS; ETHANOL; FLAVANONES; FLUORENES; GASTRIC MUCOSA; GLUCOCORTICOIDS; LIPOXYGENASE; LIPOXYGENASE INHIBITORS; MALE; OLIGOPEPTIDES; PROSTAGLANDIN ANTAGONISTS; PYRAZOLES; RATS; RATS, WISTAR; RECEPTORS, FORMYL PEPTIDE; RECEPTORS, LIPOXIN; REPERFUSION INJURY; SODIUM SALICYLATE; SULFONAMIDES;

EID: 70350041504     PISSN: 00317012     EISSN: None     Source Type: Journal    
DOI: 10.1159/000248165     Document Type: Article

References (17)

1. Robert A, Nezamis JE, Lancaster C, Davis JP, Field SO, Hanchar AJ: Mild irritants prevent gastric necrosis through 'adaptive cytoprotection' mediated by prostaglandins. Am J Physiol 1983; 245:G113-G121.
2. Robert A: Gastric cytoprotection by sodium salicylate. Prostaglandins 1981; 21(suppl): 139-146. (Pubitemid 11019548)
3. Maricic N, Ehrlich K, Gretzer B, Schuligoi R, Respondek M, Peskar BM: Selective cyclooxygenase- 2 inhibitors aggravate ischaemiareperfusion injury in the rat stomach. Br J Pharmacol 1999; 128: 1659-1666.
4. Peskar BM, Ehrlich K, Peskar BA: Interaction of cyclooxygenase-2 inhibitors and salicylate in gastric mucosal damage. Eur J Pharmacol 2002; 434: 65-70.
5. Gretzer B, Ehrlich K, Maricic N, Lambrecht N, Respondek M, Peskar BM: Selective cyclo- oxygenase-2 inhibitors and their influence on the protective effect of a mild irritant in the rat stomach. Br J Pharmacol 1998; 123: 927-935.
6. Peskar BM, Ehrlich K, Schuligoi R, Peskar BA: Role of lipoxygenases and the lipoxin A 4 / annexin-1 receptor in ischemia-reperfusioninduced gastric mucosal damage in rats. Pharmacology 2009; 84: 294-299.
7. Gillard J, Ford-Hutchinson AW, Chan C, Charleson S, Foster A, Fortin R, Leger S, Mc- Farlane CS, Morton H, Piechuta H, Riendeau D, Rouzer CA, Rokach J, Young R, MacIntyre E, Peterson L, Eirmann G, Hopple S, Hupe L, Meurer R, Opas E, Pacholok S: L-663536 (MK886) (3-[1-(4-chlorobenzyl)-3-t-butylthio- 5-isopropylindol-2-yl]-2,2-dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor. Can J Physiol Pharmacol 1989; 67: 456-464.
8. Anderson KM, Harris JE: 5,8,11,14-eicosatetraynoic acid inhibits PC3 DNA synthesis and cellular proliferation, in part due to its 5-lipoxygenase activity. Clin Physiol Biochem 1990; 8: 308-313.
9. Sekiya K, Okuda H: Selective inhibition of platelet lipoxygenase by baicalein. Biochem Biophys Res Commun 1982; 105: 1090-1095. (Pubitemid 13219433)
10. Sendobry SM, Cornicelli JA, Welch K, Bocan T, Tait B, Trivedi BK, Colbry N, Dyer RD, Feinmark SJ, Daugherty A: Attenuation of diet-induced atherosclerosis in rabbits with a highly selective 15-lipoxygenase inhibitor lacking significant antioxidant properties. Br J Pharmacol 1997; 120: 1199-1206.
11. Zanardo RC, Perretti M, Wallace JL: Annexin- 1 is an endogenous gastroprotective factor against indomethacin-induced damage. Am J Physiol Gastrointest Liver Physiol 2005; 288:G481-G486.
12. John CD, Sahni V, Mehet D, Morris JF, Christian HC, Perretti M, Flower RJ, Solito E, Buckingham JC: Formyl peptide receptors and the regulation of ACTH secretion: targets for annexin-1, lipoxins, and bacterial peptides. FASEB J 2007; 21: 1037-1046.
13. Stroff T, Plate S, Ebrahim JS, Ehrlich K, Respondek M, Peskar BM: Tachykinin-induced increase in gastric mucosal resistance: role of afferent neurons, CGRP and NO. Am J Physiol Gastrointest Liver Physiol 1996; 271: G1017-G1027. (Pubitemid 27034376)
14. Fiorucci S, de Lima OM Jr, Mencarelli A, Palazzetti B, Distrutti E, McKnight W, Dicay M, Ma L, Romano M, Morelli A, Wallace JL: Cyclooxygenase-2- derived lipoxin A 4 increases gastric resistance to aspirin-induced damage. Gastroenterology 2002; 123: 1598-1606.
15. Fierro IM, Serhan CN: Mechanisms in antiinflammation and resolution: the role of lipoxins and aspirin-triggered lipoxins. Braz J Med Biol Res 2001; 34: 555-566.
16. Martin GR, Perretti M, Flower RJ, Wallace JL: Annexin-1 modulates repair of gastric mucosal injury. Am J Physiol Gastrointest Liver Physiol 2008; 294:G764-G769.
17. Souza MH, de Lima OM Jr, Zamuner SR, Fiorucci S, Wallace JL: Gastritis increases resistance to aspirin-induced mucosal injury via COX-2-mediated lipoxin synthesis. Am J Physiol Gastrointest Liver Physiol 2003; 285: G54-G61.