Regio-selective synthesis of novel 1-tert-butyl-4-nitro-1H-pyrrole-3-carboxylic acid building block

Tetrahedron Letters

Volumn 50, Issue 49, 2009, Pages 6807-6809

  Nguyen, Duyan V ^a   Schiksnis, Robert A ^a   Michelotti, Enrique L ^a  

^a Locus Pharmaceuticals   (United States)

Author keywords

1 tert Butyl 4 nitro 1H pyrrole 3 carboxylic acid; Electrophilic substitution; Regio selective

Indexed keywords

1 TER BUTYL 4 NITRO 1H PYRROLE 3 CARBOXYLIC ACID; CARBOXYLIC ACID; UNCLASSIFIED DRUG;

ACYLATION; ARTICLE; CHEMICAL STRUCTURE; CRYSTALLIZATION; CYCLOADDITION; MICROWAVE IRRADIATION; STEREOCHEMISTRY; SYNTHESIS;

EID: 70350036069     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2009.09.099     Document Type: Article

References (12)

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10. 6): δ (ppm) 7.82-7.83 (m, 1H, H-2), 7.19 (dd, J = 3.2, 2.2 Hz, 1H, H-5), 6.68-6.70 (m(8), 1H, H-4), 1.63 (s, 9H, t-butyl).
11. HF = 1.4 Hz, 1H, H-2), 1.72 (s, 9H, t-butyl).
12. 6): δ (ppm) 10.50 (br s, 1H), 7.98 (d, J = 2.7 Hz, 1H, H-5), 7.61 (d, J = 2.7 Hz, 1H, H-2), 1.67 (s, 9H, t-butyl).