Serine protease inhibitor Kazal type 1 (SPINK1): Beyond the trypsin inhibitor

Current Enzyme Inhibition

Volumn 5, Issue 2, 2009, Pages 110-116

  Ohmuraya, Masaki ^a   Ozaki, Nobuyuki ^a   Hirota, Masahiko ^b   Baba, Hideo ^a   Yamamura, Ken Ichi ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

^b KUMAMOTO REGIONAL MEDICAL CENTER   (Japan)

Author keywords

Autophagy; EGF; EGFR; PSTI; Seminal vesicle; SPINK1; Spink3

Indexed keywords

APROTININ; EPIDERMAL GROWTH FACTOR RECEPTOR; SERINE PROTEINASE INHIBITOR; SERINE PROTEINASE INHIBITOR KAZAL TYPE 1; SERINE PROTEINASE INHIBITOR KAZAL TYPE 3; TRYPSINOGEN; UNCLASSIFIED DRUG;

ACUTE PANCREATITIS; AUTOPHAGY; CALCIUM TRANSPORT; CELL DIFFERENTIATION; CELL PROLIFERATION; CHRONIC PANCREATITIS; ENZYME ACTIVATION; GENE EXPRESSION; GENE FUNCTION; GENE LOCATION; GENE MUTATION; HUMAN; MALIGNANT NEOPLASTIC DISEASE; NONHUMAN; PANCREAS ISLET CELL; PROTEIN DEGRADATION; REGULATORY MECHANISM; REVIEW; SPERM;

MUS;

EID: 70350025044     PISSN: 15734080     EISSN: None     Source Type: Journal    
DOI: 10.2174/157340809788680493     Document Type: Review

References (52)

1. Marchbank, T.; Freeman, T.C.; Playford, R.J. Human pancreatic secretory trypsin inhibitor. Distribution, actions and possible role in mucosal integrity and repair. Digestion, 1998, 59, 167-174.
2. Kazal, L.A.; Spicer, D.S.; Brahinsky, R.A. Isolation of a crystalline trypsin inhibitor-anticoagulant protein from pancreas. J. Am. Chem. Soc., 1948, 70, 304-340.
3. Laskowski, M.; Wu, F.C. Temporary inhibition of trypsin. J. Biol. Chem., 1953, 204, 797-805.
4. Horii, A.; Kobayashi, T.; Tomita, N.; Yamamoto, T.; Fukushige, S.; Murotsu, T.; Ogawa, M.; Mori, T.; Matsubara, K. Primary structure of human pancreatic secretory trypsin inhibitor (PSTI) gene. Biochem. Biophys. Res. Commun., 1987, 149, 635-641.
5. Hirota, M.; Ohmuraya, M.; Baba, H. Genetic background of pancreatitis. Postgrad. Med. J., 2006, 82, 775-778.
6. Whitcomb, D.C.; Gorry, M.C.; Preston, R.A.; Furey, W.; Sossenheimer, M. J.; Ulrich, C. D.; Martin, S. P.; Gates, L. K., Jr.; Amann, S. T.; Toskes, P. P.; Liddle, R.; McGrath, K.; Uomo, G.; Post, J. C.; Ehrlich, G. D. Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene. Nat. Genet., 1996, 14, 141-145.
7. Greenbaum, L.M.; Hirshkowitz, A.; Shoichet, I. The activation of trypsinogen by cathepsin B. J. Biol. Chem., 1959, 234, 2885-2890.
8. Saluja, A.K.; Lerch, M.M.; Phillips, P.A.; Dudeja, V. Why does pancreatic overstimulation cause pancreatitis? Annu. Rev. Physiol., 2007, 69, 249-269.
9. Witt, H.; Luck, W.; Hennies, H.C.; Classen, M.; Kage, A.; Lass, U.; Landt, O.; Becker, M. Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis. Nat. Genet., 2000, 25, 213-216.
10. Kuwata, K.; Hirota, M.; Sugita, H.; Kai, M.; Hayashi, N.; Nakamura, M.; Matsuura, T.; Adachi, N.; Nishimori, I.; Ogawa, M. Genetic mutations in exons 3 and 4 of the pancreatic secretory trypsin inhibitor in patients with pancreatitis. J. Gastroenterol., 2001, 36, 612-618.
11. Pfutzer, R.H.; Barmada, M.M.; Brunskill, A.P.; Finch, R.; Hart, P.S.; Neoptolemos, J.; Furey, W.F.; Whitcomb, D.C. SPINK1/PSTI polymorphisms act as disease modifiers in familial and idiopathic chronic pancreatitis. Gastroenterology, 2000, 119, 615-623.
12. Chen, J.M.; Mercier, B.; Audrezet, M.P.; Raguenes, O.; Quere, I.; Ferec, C. Mutations of the pancreatic secretory trypsin inhibitor (PSTI) gene in idiopathic chronic pancreatitis. Gastroenterology, 2001, 120, 1061-1064.
13. Kaneko, K.; Nagasaki, Y.; Furukawa, T.; Mizutamari, H.; Sato, A.; Masamune, A.; Shimosegawa, T.; Horii, A. Analysis of the human pancreatic secretory trypsin inhibitor (PSTI) gene mutations in Japanese patients with chronic pancreatitis. J. Hum. Genet., 2001, 46, 293-297.
14. Kuwata, K.; Hirota, M.; Nishimori, I.; Otsuki, M.; Ogawa, M. Mutational analysis of the pancreatic secretory trypsin inhibitor gene in familial and juvenile pancreatitis in Japan. J. Gastroenterol., 2003, 38, 365-370.
15. Hirota, M.; Kuwata, K.; Ohmuraya, M.; Ogawa, M. From acute to chronic pancreatitis: the role of mutations in the pancreatic secretory trypsin inhibitor gene. JOP, 2003, 4, 83-88.
16. Ohmuraya, M.; Hirota, M.; Araki, M.; Mizushima, N.; Matsui, M.; Mizumoto, T.; Haruna, K.; Kume, S.; Takeya, M.; Ogawa, M.; Araki, K.; Yamamura, K. Autophagic cell death of pancreatic acinar cells in serine protease inhibitor Kazal type 3-deficient mice. Gastroenterology, 2005, 129, 696-705.
17. Chera, S.; de Rosa, R.; Miljkovic-Licina, M.; Dobretz, K.; Ghila, L.; Kaloulis, K.; Galliot, B. Silencing of the hydra serine protease inhibitor Kazal1 gene mimics the human SPINK1 pancreatic phenotype. J. Cell Sci., 2006, 119, 846-857.
18. Hochstrasser, M. Ubiquitin-dependent protein degradation. Annu. Rev. Genet., 1996, 30, 405-439.
19. Hershko, A.; Ciechanover, A. The ubiquitin system. Annu. Rev. Biochem., 1998, 67, 425-479.
20. Mortimore, G.E.; Poso, A.R. Intracellular protein catabolism and its control during nutrient deprivation and supply. Annu. Rev. Nutr., 1987, 7, 539-564.
21. Seglen, P.O.; Bohley, P. Autophagy and other vacuolar protein degradation mechanisms. Experientia, 1992, 48, 158-172.
22. Kim, J.; Klionsky, D.J. Autophagy, cytoplasm-to-vacuole targeting pathway, and pexophagy in yeast and mammalian cells. Annu. Rev. Biochem., 2000, 69, 303-342.
23. Meijer, A. J. Amino acids as regulators and components of nonproteinogenic pathways. J. Nutr., 2003, 133, 2057S-2062S.
24. Lemasters, J.J.; Qian, T.; He, L.; Kim, J.S.; Elmore, S.P.; Cascio, W.E.; Brenner, D.A. Role of mitochondrial inner membrane permeabilization in necrotic cell death, apoptosis, and autophagy. Antioxid Redox Signal., 2002, 4, 769-781.
25. Bellu, A.R.; Kiel, J.A. Selective degradation of peroxisomes in yeasts. Microsc. Res. Tech., 2003, 61, 161-170.
26. Roberts, P.; Moshitch-Moshkovitz, S.; Kvam, E.; O'Toole, E.; Winey, M.; Goldfarb, D.S. Piecemeal microautophagy of nucleus in Saccharomyces cerevisiae. Mol. Biol. Cell, 2003, 14, 129-141.
27. Hennig, K.M.; Neufeld, T.P. Inhibition of cellular growth and proliferation by dTOR overexpression in Drosophila. Genesis, 2002, 34, 107-110.
28. Jacinto, E.; Hall, M.N. Tor signalling in bugs, brain and brawn. Nat. Rev. Mol. Cell Biol., 2003, 4, 117-126.
29. Melendez, A.; Talloczy, Z.; Seaman, M.; Eskelinen, E.L.; Hall, D.H.; Levine, B. Autophagy genes are essential for dauer development and life-span extension in C. elegans. Science, 2003, 301, 1387-1391.
30. Otto, G.P.; Wu, M.Y.; Kazgan, N.; Anderson, O.R.; Kessin, R.H. Macroautophagy is required for multicellular development of the social amoeba Dictyostelium discoideum. J. Biol. Chem., 2003, 278, 17636-17645.
31. Hashimoto, D.; Ohmuraya, M.; Hirota, M.; Yamamoto, A.; Suyama, K.; Ida, S.; Okumura, Y.; Takahashi, E.; Kido, H.; Araki, K.; Baba, H.; Mizushima, N.; Yamamura, K. Involvement of autophagy in trypsinogen activation within the pancreatic acinar cells. J. Cell Biol., 2008, 181, 1065-1072.
32. Steer, M.L.; Meldolesi, J.; Figarella, C. Pancreatitis. The role of lysosomes. Dig. Dis. Sci., 1984, 29, 934-938.
33. Steer, M.L.; Meldolesi, J. The cell biology of experimental pancreatitis. N. Engl. J. Med., 1987, 316, 144-150.
34. van Acker, G.J.; Perides, G.; Steer, M.L. Co-localization hypothesis: a mechanism for the intrapancreatic activation of digestive enzymes during the early phases of acute pancreatitis. World J. Gastroenterol., 2006, 12, 1985-1990.
35. Leach, S.D.; Modlin, I.M.; Scheele, G.A.; Gorelick, F.S. Intracellular activation of digestive zymogens in rat pancreatic acini. Stimulation by high doses of cholecystokinin. J. Clin. Invest., 1991, 87, 362-366.
36. Ohmuraya, M.; Yamamura, K. Autophagy and acute pancreatitis: a novel autophagy theory for trypsinogen activation. Autophagy, 2008, 4, 1060-1062.
37. Kuwata, K.; Hirota, M.; Shimizu, H.; Nakae, M.; Nishihara, S.; Takimoto, A.; Mitsushima, K.; Kikuchi, N.; Endo, K.; Inoue, M.; Ogawa, M. Functional analysis of recombinant pancreatic secretory trypsin inhibitor protein with amino-acid substitution. J. Gastroenterol., 2002, 37, 928-934.
38. Bohe, M.; Lindstrom, C.G.; Ohlsson, K. Varying occurrence of gastroduodenal immunoreactive pancreatic secretory trypsin inhibitor. J. Clin. Pathol., 1987, 40, 1345-1348.
39. Fukayama, M.; Hayashi, Y.; Koike, M.; Ogawa, M.; Kosaki, G. Immunohistochemical localization of pancreatic secretory trypsin inhibitor in fetal and adult pancreatic and extrapancreatic tissues. J. Histochem. Cytochem., 1986, 34, 227-235.
40. Matsuda, K.; Ogawa, M.; Murata, A.; Kitahara, T.; Kosaki, G. Elevation of serum immunoreactive pancreatic secretory trypsin inhibitor contents in various malignant diseases. Res. Commun. Chem. Pathol. Pharmacol., 1983, 40, 301-305.
41. Shibata, T.; Ogawa, M.; Takata, N.; Matsuda, K.; Niinobu, T.; Uda, K.; Wakasugi, C.; Mori, T. Distribution of pancreatic secretory trypsin inhibitor in various human tissues and its inactivation in the gastric mucosa. Res. Commun. Chem. Pathol. Pharmacol., 1987, 55, 243-248.
42. Wang, J.; Ohmuraya, M.; Hirota, M.; Baba, H.; Zhao, G.; Takeya, M.; Araki, K.; Yamamura, K. Expression pattern of serine protease inhibitor kazal type 3 (Spink3) during mouse embryonic development. Histochem. Cell Biol., 2008, 130, 387-397.
43. Huhtala, M.L.; Kahanpaa, K.; Seppala, M.; Halila, H.; Stenman, U.H. Excretion of a tumor-associated trypsin inhibitor (TATI) in urine of patients with gynecological malignancy. Int. J. Cancer, 1983, 31, 711-714.
44. Huhtala, M.L.; Pesonen, K.; Kalkkinen, N.; Stenman, U.H. Purification and characterization of a tumor-associated trypsin inhibitor from the urine of a patient with ovarian cancer. J. Biol. Chem., 1982, 257, 13713-13716.
45. Stenman, U.H. Tumor-associated trypsin inhibitor. Clin. Chem., 2002, 48, 1206-1209.
46. Tonouchi, A.; Ohtsuka, M.; Ito, H.; Kimura, F.; Shimizu, H.; Kato, M.; Nimura, Y.; Iwase, K.; Hiwasa, T.; Seki, N.; Takiguchi, M.; Miyazaki, M. Relationship between pancreatic secretory trypsin inhibitor and early recurrence of intrahepatic cholangiocarcinoma following surgical resection. Am. J. Gastroenterol., 2006, 101, 1601-1610.
47. Tomlins, S.A.; Rhodes, D.R.; Yu, J.; Varambally, S.; Mehra, R.; Perner, S.; Demichelis, F.; Helgeson, B.E.; Laxman, B.; Morris, D.S.; Cao, Q.; Cao, X.; Andren, O.; Fall, K.; Johnson, L.; Wei, J.T.; Shah, R.B.; Al-Ahmadie, H.; Eastham, J.A.; Eggener, S.E.; Fine, S.W.; Hotakainen, K.; Stenman, U.H.; Tsodikov, A.; Gerald, W.L.; Lilja, H.; Reuter, V.E.; Kantoff, P.W.; Scardino, P.T.; Rubin, M.A.; Bjartell, A.S.; Chinnaiyan, A.M. The role of SPINK1 in ETS rearrangement-negative prostate cancers. Cancer Cell, 2008, 13, 519-528.
48. Yamamoto, T.; Nakamura, Y.; Nishide, J.; Emi, M.; Ogawa, M.; Mori, T.; Matsubara, K. Molecular cloning and nucleotide sequence of human pancreatic secretory trypsin inhibitor (PSTI) cDNA. Biochem. Biophys. Res. Commun., 1985, 132, 605-612.
49. Ogawa, M.; Tsushima, T.; Ohba, Y.; Ogawa, N.; Tanaka, S.; Ishida, M.; Mori, T. Stimulation of DNA synthesis in human fibroblasts by human pancreatic secretory trypsin inhibitor. Res. Commun. Chem. Pathol. Pharmacol., 1985, 50, 155-158.
50. Fukuoka, S.; Fushiki, T.; Kitagawa, Y.; Sugimoto, E.; Iwai, K. Competition of a growth stimulating-/cholecystokinin (CCK) releasing-peptide (monitor peptide) with epidermal growth factor for binding to 3T3 fibroblasts. Biochem. Biophys. Res. Commun., 1987, 145, 646-650.
51. Marchbank, T.; Chinery, R.; Hanby, A.M.; Poulsom, R.; Elia, G.; Playford, R.J. Distribution and expression of pancreatic secretory trypsin inhibitor and its possible role in epithelial restitution. Am. J. Pathol., 1996, 148, 715-722.
52. Chen, L.Y.; Lin, Y.H.; Lai, M.L.; Chen, Y.H. Developmental profile of a caltrin-like protease inhibitor, P12, in mouse seminal vesicle and characterization of its binding sites on sperm surface. Biol. Reprod., 1998, 59, 1498-1505.