Synthesis of pyrrolo[1,3]diazepines by a dipolar cycloaddition-retro-Mannich domino reaction

Tetrahedron Letters

Volumn 50, Issue 49, 2009, Pages 6810-6813

  Liang, Mary ^a   Saiz, Cecilia ^a   Pizzo, Chiara ^a   Wipf, Peter ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3,4,5 TETRAHYDRO 1H PYRROLO[1,2 C][1,3]DIAZEPINE; 4 THIO 3 OXAZOLIN 5 ONE DERIVATIVE; DIAZEPINE DERIVATIVE; ETHYL CYANOFORMATE; FORMIC ACID; OXAZOLONE; PYRROLO[1,3]DIAZEPINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL STRUCTURE; CYCLOADDITION; HEATING; MANNICH REACTION; MICROWAVE IRRADIATION; SYNTHESIS;

EID: 70350010184     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2009.09.107     Document Type: Article

References (24)

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22. 2SNa (M+Na) 375.1143, found 375.1114.
23. 4SNa (M+Na) 473.1502, found 473.1511.
24. 3, 300 K) δ 7.35-7.11 (m, 10 H), 5.85 (dt, 1 H, J = 5.7, 15.5 Hz), 5.38 (dt, 1 H, J = 6.3, 15.5 Hz), 4.76 (d, 2 H, J = 5.7 Hz), 4.38 (s, 2 H), 3.86 (s, 3 H), 3.77 (s, 3 H), 3.68-3.65 (m, 2 H), 3.12 (br s, 2 H), 2.90-2.85 (m, 2 H), 2.82 (s, 3 H), 1.78-1.69 (m, 2 H).