Inhibition of peroxynitrite-mediated DNA strand cleavage and hydroxyl radical formation by aspirin at pharmacologically relevant concentrations: Implications for cancer intervention

Biochemical and Biophysical Research Communications

Volumn 390, Issue 1, 2009, Pages 142-147

  Chen, Wei ^a,b,c   Zhu, Hong ^a   Jia, Zhenquan ^a   Li, Jianrong ^b   Misra, Hara P ^a   Zhou, Kequan ^d   Li, Yunbo ^a  

^a EDWARD VIA COLLEGE OF OSTEOPATHIC MEDICINE   (United States)

^b ZHEJIANG GONGSHANG UNIVERSITY   (China)

^c VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

^d WAYNE STATE UNIVERSITY   (United States)

Author keywords

Aspirin; DNA cleavage; Hydroxyl radical; Peroxynitrite

Indexed keywords

5,5 DIMETHYL 1 PYRROLINE 1 OXIDE; ACETYLSALICYLIC ACID; ANTIINFLAMMATORY AGENT; HYDROXYL RADICAL; LINSIDOMINE; PEROXYNITRITE; PLASMID DNA;

ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; AUTOOXIDATION; DNA DAMAGE; DNA STRAND BREAKAGE; DRUG INHIBITION; ELECTRON SPIN RESONANCE; HUMAN; HUMAN CELL; OXYGEN CONSUMPTION; PRIORITY JOURNAL; SPIN TRAPPING;

ANTICARCINOGENIC AGENTS; ASPIRIN; BACTERIOPHAGE PHI X 174; DNA CLEAVAGE; HUMANS; HYDROXYL RADICAL; MOLSIDOMINE; NEOPLASMS; PEROXYNITROUS ACID; PLASMIDS;

EID: 70350008255     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.09.083     Document Type: Article

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