Hypoglycaemia: An overview

Primary Care Diabetes

Volumn 3, Issue 3, 2009, Pages 131-139

  Graveling, Alex J ^a   Frier, Brian M ^a  

^a ROYAL INFIRMARY OF EDINBURGH   (United Kingdom)

Author keywords

Diabetes; Driving; Hypoglycaemia; Impaired awareness of hypoglycaemia; Treatment of hypoglycaemia

Indexed keywords

ANTICONVULSIVE AGENT; CARBOHYDRATE; GLIBENCLAMIDE; GLUCAGON; GLUCOSE; HEMOGLOBIN A1C; INSULIN; INSULIN DERIVATIVE; MANNITOL; SULFONYLUREA;

BRAIN EDEMA; CARDIOVASCULAR EFFECT; CLINICAL TRIAL; CONTINUOUS INFUSION; DAILY LIFE ACTIVITY; DIABETES MELLITUS; DIABETIC PATIENT; DRIVING ABILITY; GLYCEMIC CONTROL; HUMAN; HYPOGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN HYPOGLYCEMIA; JOB PERFORMANCE; MORBIDITY; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; RECREATION; REVIEW; RISK REDUCTION;

ACTIVITIES OF DAILY LIVING; DIABETES MELLITUS; DIABETES MELLITUS, TYPE 2; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; HYPOGLYCEMIA; HYPOGLYCEMIC AGENTS; INSULIN; PREVALENCE; RISK FACTORS;

EID: 70350007158     PISSN: 17519918     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pcd.2009.08.007     Document Type: Review

References (76)

1. The Diabetes Control Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N. Engl. J. Med. 329 (1993) 977-986
2. DCCT/EDIC Study Research Group. Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes. N. Engl. J. Med. 353 (2005) 2643-2653
3. UK Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 352 (1998) 837-853
4. Holman R.R., Paul S.K., and Bethel A.B. 10-Year follow-up of intensive glucose control in type 2 diabetes. N. Engl. J. Med. 359 (2008) 1577-1589
5. Cryer P.E. The barrier of hypoglycemia in diabetes. Diabetes 57 (2008) 3169-3176
6. Pramming S., Thorsteinsson B., Bendtson I., and Binder C. Symptomatic hypoglycaemia in 411 type 1 diabetic patients. Diabet. Med. 8 (1991) 217-222
7. Frier B.M. Defining hypoglycaemia: what level has clinical relevance?. Diabetologia 52 (2009) 31-34
8. Cryer P.E. Preventing hypoglycaemia: what is the appropriate glucose alert value?. Diabetologia 52 (2009) 35-37
9. Pedersen-Bjergaard U., Agerholm-Larsen B., Pramming S., et al. Prediction of severe hypoglycaemia by angiotensin-converting enzyme activity and genotype in type 1 diabetes. Diabetologia 46 (2003) 89-96
10. Swinnen S.G.H., Mullins P., Miller M., Hoekstra J.B.L., and Holleman F. Changing the glucose cut-off values that define hypoglycaemia has a major effect on reported frequencies of hypoglycaemia. Diabetologia 52 (2008) 38-41
11. Strachan M.W.J. Frequency causes and risk factors for hypoglycaemia in type 1 diabetes. In: Frier B.M., and Fisher M. (Eds). Hypoglycaemia in Clinical Diabetes. 2nd ed. (2007), John Wiley & Sons, Chichester 49-82
12. UK Hypoglycaemia Study Group. Risk of hypoglycaemia in types 1 and 2 diabetes: effects of treatment modalities and their duration. Diabetologia 50 (2007) 1140-1147
13. Pedersen-Bjergaard U., Pramming S., Heller S.R., et al. Severe hypoglycaemia in 1076 adult patients with type 1 diabetes: influence of risk markers and selection. Diabetes Metab. Res. Rev. 20 (2004) 479-486
14. Henderson J.N., Allen K.V., Deary I.J., and Frier B.M. Hypoglycaemia in insulin-treated Type 2 diabetes: frequency, symptoms and impaired awareness. Diabet. Med. 20 (2003) 1016-1021
15. Leiter L.A., Yale J., Chiasson J., et al. Assessment of the impact of fear of hypoglycemic episodes on glycemic and hypoglycemia management. Can. J. Diabetes 29 (2005) 186-192
16. Donnelly L.A., Morris A.D., Frier B.M., et al., for the DARTS/MEMO Collaboration. Frequency and predictors of hypoglycaemia in Type 1 and insulin-treated Type 2 diabetes: a population-based study. Diabet. Med. 22 (2005) 749-755
17. McAulay V., Frier B.M., and Hypoglycaemia. In: Sinclair A.J. (Ed). Diabetes in Old Age. 3rd ed. (2009), John Wiley & Sons, Chichester 287-310
18. Caplin N.J., O'Leary P., Bulsara M., et al. Subcutaneous glucose sensor values closely parallel blood glucose during insulin-induced hypoglycaemia. Diabet. Med. 20 (2003) 238-241
19. Chico A., Vidal-Rios P., Subira M., and Novials A. The continuous glucose monitoring system is useful for detecting unrecognized hypoglycemias in patients with type 1 and type 2 diabetes but is not better than frequent capillary glucose measurements for improving metabolic control. Diabetes Care 26 (2003) 1153-1157
20. Hoi-Hansen T., Pedersen-Bjergaard U., and Thorsteinsson B. Reproducibility and reliability of hypoglycaemic episodes recorded with continuous glucose monitoring system (CGMS) in daily life. Diabet. Med. 22 (2005) 858-862
21. Guillod L., Comte-Perret S., Monbaron D., et al. Nocturnal hypoglycaemia in type 1 diabetic patients: what can we learn with continuous glucose monitoring?. Diabetes Metab. 33 (2007) 360-365
22. Deary I.J., Hepburn D.A., MacLeod K.M., and Frier B.M. Partitioning the symptoms of hypoglycaemia using multi-sample confirmatory factor analysis. Diabetologia 36 (1993) 771-777
23. McAulay V., Deary I.J., and Frier B.M. Symptoms of hypoglycaemia in people with diabetes. Diabet. Med. 18 (2001) 690-705
24. Deary I.J. Symptoms of hypoglycaemia and effects on mental performance and emotions. In: Frier B.M., and Fisher M. (Eds). Hypoglycaemia in Clinical Diabetes. 2nd ed. (2007), John Wiley & Sons, Chichester 25-48
25. Airey C.M., Williams D.R.R., Martin P.G., et al. Hypoglycaemia induced by exogenous insulin-'human' and animal insulin compared. Diabet. Med. 17 (2000) 416-432
26. Wright R.J., and Frier B.M. Vascular disease and diabetes: is hypoglycaemia an aggravating factor?. Diabetes Metab. Res. Rev. 24 (2008) 353-363
27. The Action to Control Cardiovascular Risk in Diabetes Study Group. Effects of intensive glucose lowering in type 2 diabetes. N. Engl. J. Med. 358 (2008) 2545-2559
28. Bloomgarden Z.T. Glycemic control in diabetes: a tale of three studies. Diabetes Care 31 (2008) 1913-1919
29. NICE-SUGAR Study Investigators. Intensive versus conventional glucose control in critically ill patients. N. Engl. J. Med. 360 (2009) 1283-1297
30. Laing S.P., Swerdlow A.J., Slater S.D., et al. The British Diabetic Association cohort study II: cause specific mortality in patients with insulin-treated diabetes mellitus. Diabet. Med. 16 (1999) 466-471
31. Tattersall R.B., and Gill G.V. Unexplained deaths of type 1 diabetic patients. Diabet. Med. 8 (1991) 49-50
32. Robinson R.T., Harris N.D., Ireland R.H., et al. Mechanisms of abnormal cardiac repolarisation during insulin-induced hypoglycemia. Diabetes 52 (2003) 1469-1474
33. Koivikko M.L., Karikas M., Salmela P.I., Tapanainen J.S., et al. Effects of controlled hypoglycaemia on cardiac repolarisation in patients with type 1 diabetes. Diabetologia 51 (2008) 426-435
34. Desouza C., Salazar H., Cheong B., et al. Association of hypoglycemia and cardiac ischemia. Diabetes Care 26 (2003) 1485-1489
35. MacLeod K.M., Hepburn D.A., and Frier B.M. Frequency and morbidity of severe hypoglycaemia in insulin-treated diabetic patients. Diabet. Med. 10 (1993) 238-245
36. Perros P., and Deary I.J. Long-term effects of hypoglycaemia on cognitive function and the brain in diabetes. In: Frier B.M., and Fisher M. (Eds). Hypoglycaemia in Clinical Diabetes. 2nd ed. (2007), John Wiley & Sons, Chichester 285-307
37. Matyka K., Evans M., Lomas J., et al. Altered hierarchy of protective responses against severe hypoglycemia in normal aging in healthy men. Diabetes Care 20 (1997) 135-141
38. Zammitt N.N., Warren R.E., Deary I.J., and Frier B.M. Delayed recovery of cognitive function following hypoglycemia in adults with type 1 diabetes. Diabetes 57 (2008) 732-736
39. DCCT/EDIC. Long-term effect of diabetes and its treatment of cognitive function. N. Engl. J. Med. 356 (2007) 1842-1852
40. Biessels G.J., Deary I.J., and Ryan C.M. Cognition and diabetes: a lifespan perspective. Lancet Neurol. 7 (2008) 184-190
41. Wild D., von Maltzahn R., Brohan E., et al. A critical review of the literature on fear of hypoglycemia in diabetes: implications for diabetes management and patient education. Patient Educ. Couns. 68 (2007) 10-15
42. Jorgensen H.V., Pedersen-Bjergaard U., Rasmussen A.K., and Borch-Johnsen K. The impact of severe hypoglycemia and impaired awareness of hypoglycemia on relatives of patients with type 1 diabetes. Diabetes Care 26 (2003) 1106-1109
43. McCrimmon R.J., Frier B.M., and Deary I.J. Appraisal of mood and personality during hypoglycaemia in human subjects. Physiol. Behav. 67 (1999) 27-33
44. Cryer P.E. Mechanisms of hypoglycemia-associated autonomic failure and its component syndromes in diabetes. Diabetes 54 (2005) 3592-3601
45. Zammitt N.N., and Frier B.M. Hypoglycemia in type 2 diabetes. Diabetes Care 28 (2005) 2948-2961
46. Hepburn D.A., Deary I.J., and Frier B.M. Classification of symptoms of hypoglycaemia in insulin-treated diabetic patients using factor analysis: relationship to hypoglycaemia unawareness. Diabet. Med. 9 (1992) 70-75
47. Gold A.E., MacLeod K.M., and Frier B.M. Frequency of severe hypoglycemia in patients with type 1 diabetes with impaired awareness of hypoglycemia. Diabetes Care 17 (1994) 697-703
48. Geddes J., Schopman J.E., Zammitt N.N., and Frier B.M. Prevalence of impaired awareness of hypoglycaemia in adults with type 1 diabetes. Diabet. Med. 25 (2008) 501-504
49. Clarke W.L., Cox D.J., Gonder-Frederick L.A., et al. Reduced awareness of hypoglycemia in adults with IDDM: a prospective study of hypoglycemic frequency and associated symptoms. Diabetes Care 18 (1995) 517-522
50. Geddes J., Wright R.J., Zammitt N.N., et al. An evaluation of methods of assessing impaired awareness of hypoglycemia in type 1 diabetes. Diabetes Care 30 (2007) 1868-1870
51. Boyle P.J., Nagy R.J., O'Connor A.M., et al. Adaptation in brain glucose uptake following recurrent hypoglycemia. Proc. Natl. Acad. Sci. U.S.A. 91 (1994) 9352-9356
52. Frier B.M. Impaired awareness of hypoglycaemia. In: Frier B.M., and Fisher M. (Eds). Hypoglycaemia in Clinical Diabetes. 2nd ed. (2007), John Wiley & Sons, Chichester 141-170
53. Heller S.R. Minimizing hypoglycemia while maintaining glycemic control in diabetes. Diabetes 57 (2008) 3177-3183
54. Hovarth K., Jeitler K., Berghold A., et al. Long-acting insulin analogues versus NPH insulin (human isophane insulin) for type 2 diabetes mellitus. Cochrane Database Syst. Rev. (2007) Art. No. CD005613
55. Jeitler K., Hovarth K., Berghold A., et al. Continuous subcutaneous insulin infusion versus multiple daily insulin injections in patients with diabetes mellitus: systematic review and meta-analysis. Diabetologia 51 (2008) 941-951
56. National Institute for Health and Clinical Excellence. Continuous Subcutaneous Insulin Infusion for the Treatment of Diabetes Mellitus (2008). http://www.nice.org.uk/Guidance/TA151 http://www.nice.org.uk/Guidance/TA151
57. Richardson T., and Kerr D. Moderators, monitoring and management of hypoglycaemia. In: Frier B.M., and Fisher M. (Eds). Hypoglycaemia in Clinical Diabetes. 2nd ed. (2007), John Wiley & Sons, Chichester 101-120
58. Richardson T., Weiss M., Thomas P., and Kerr D. Day after the night before: influence of evening alcohol on risk of hypoglycemia in patients with type 1 diabetes. Diabetes Care 28 (2005) 1801-1802
59. Debrah K., Sherwin R.S., Murphy J., and Kerr D. Effect of caffeine on recognition of and physiological responses to hypoglycaemia in insulin-dependent diabetes. Lancet 347 (1996) 19-24
60. Richardson T., Thomas P., Ryder J., and Kerr D. Influence of caffeine on frequency of hypoglycemia detected by continuous interstitial glucose monitoring system in patients with long-standing type 1 diabetes. Diabetes Care 28 (2005) 1316-1320
61. Muhlhauser U., Bruckner I., Berger M., et al. Evaluation of an intensified insulin treatment and teaching programme as routine management of Type 1 (insulin-dependent) diabetes. Diabetologia 30 (1987) 681-690
62. Samann A., Muhlhauser I., Bender R., et al. Glycaemic control and severe hypoglycaemia following training in flexible, intensive insulin therapy to enable dietary freedom in people with type 1 diabetes: a prospective implementation study. Diabetologia 48 (2005) 1965-1970
63. Cox D.J., Kovatchev B., Koev D., et al. Hypoglycemia anticipation, awareness and treatment training (HAATT) reduces occurrence of severe hypoglycemia among adults with type 1 diabetes mellitus. Int. J. Behav. Med. 11 (2004) 212-218
64. Cox D.J., Gonder-Frederick L.A., Kovatchev B.P., et al. Progressive hypoglycemia's impact on driving simulation performance, occurrence, awareness and correction. Diabetes Care 23 (2000) 163-170
65. Stork A.D.M., van Haeften T.W., and Veneman T.F. Diabetes and driving: desired data, research methods and their pitfalls, current knowledge and future research. Diabetes Care 29 (2006) 1942-1949
66. Graveling A.J., Warren R.E., and Frier B.M. Hypoglycaemia and driving in people with insulin-treated diabetes: adherence to recommendations for avoidance. Diabet. Med. 21 (2004) 1014-1019
67. DVLA. At a Glance Guide to the Current Medical Standards of Fitness to Drive (2009). http://www.dvla.gov.uk/media/pdf/medical/aagv1.pdf http://www.dvla.gov.uk/media/pdf/medical/aagv1.pdf
68. Diabetes UK. Driving and Diabetes (2008). https://www.diabetes.org.uk/upload/Driving_Diabetes_9044.pdf https://www.diabetes.org.uk/upload/Driving_Diabetes_9044.pdf
69. Waclawski E.R., Gill G.V., and Diabetes. Mellitus and other endocrine disorders. In: Palmer K.T., Cox R.A.F., and Brown I. (Eds). Fitness for Work: the Medical Aspects. 4th ed. (2007), Oxford University Press, Oxford 345-360
70. Leckie A.M., Graham M.K., Grant J.B., et al. Frequency, severity, and morbidity of hypoglycemia occurring in the workplace in people with insulin-treated diabetes. Diabetes Care 28 (2005) 1333-1338
71. Frier B.M. Living with hypoglycaemia. In: Frier B.M., and Fisher M. (Eds). Hypoglycaemia in Clinical Diabetes. 2nd ed. (2007), John Wiley & Sons, Chichester 309-332
72. Peirce N.S. Diabetes and exercise. Br. J. Sports Med. 33 (1999) 161-173
73. Brazeau A., Rabasa-Lohret R., Strychar I., and Mircescu H. Barriers to physical activity among patients with type 1 diabetes. Diabetes Care 31 (2008) 2108-2109
74. MacDonald M.J. Postexercise late-onset hypoglycemia in insulin-dependent diabetic patients. Diabetes Care 10 (1987) 584-588
75. Perry E., and Gallen I.W. Guidelines on the current best practice for the management of type 1 diabetes, sport and exercise. Pract. Diab. Int. 26 (2009) 116-123
76. MacCuish A.C. Treatment of Hypoglycaemia. In: Frier B.M., and Fisher B.M. (Eds). Hypoglycaemia and Diabetes, Clinical and Physiological Aspects (1993), Edward Arnold, London 212-221