Multivalent ligand-receptor interactions elicit inverse agonist activity of AT1 receptor blockers against stretch-induced AT1 receptor activation

Hypertension Research

Volumn 32, Issue 10, 2009, Pages 875-883

  Qin, Yingjie ^a,c   Yasuda, Noritaka ^a,c   Akazawa, Hiroshi ^a   Ito, Kaoru ^a   Kudo, Yoko ^a   Liao, Chien Hui ^a   Yamamoto, Rie ^a   Miura, Shin Ichiro ^b   Saku, Keijiro ^b   Komuro, Issei ^a  

^a CHIBA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b FUKUOKA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c CHENGDE MEDICAL COLLEGE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN II; ANGIOTENSIN RECEPTOR ANTAGONIST; CARBOXYL GROUP; DRUG DERIVATIVE; GLUTAMINE; HISTIDINE; HYDROXYL GROUP; LOSARTAN; LYSINE; MITOGEN ACTIVATED PROTEIN KINASE; OLMESARTAN; PROTEIN C FOS; R 239470; R 90929; TYROSINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME ACTIVATION; GENE EXPRESSION; HUMAN; HUMAN CELL; NEWBORN; NONHUMAN; PROTEIN CONFORMATION; PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN SYNTHESIS INHIBITION; RAT; STRUCTURE ACTIVITY RELATION;

ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANIMALS; BLOTTING, NORTHERN; BLOTTING, WESTERN; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; IMIDAZOLES; LIGANDS; LOSARTAN; MUTATION; MYOCYTES, CARDIAC; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RATS, WISTAR; RECEPTOR, ANGIOTENSIN, TYPE 1; RNA; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAZOLES;

EID: 70349987109     PISSN: 09169636     EISSN: 13484214     Source Type: Journal    
DOI: 10.1038/hr.2009.117     Document Type: Article

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