Inflammation and tissue repair markers distinguish the nodular sclerosis and mixed cellularity subtypes of classical Hodgkin's lymphoma

British Journal of Cancer

Volumn 101, Issue 8, 2009, Pages 1393-1401

  Birgersdotter, A ^a   Baumforth, K R N ^b   Porwit, A ^c   Sjoberg J ^c   Wei, W ^b   Bjorkholm M ^c   Murray, P G ^b   Ernberg, I ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Gene expression; Hodgkin's lymphoma; Microenvironment; Wound healing

Indexed keywords

CATHEPSIN K; CD5 ANTIGEN LIKE PROTEIN; COLLAGEN TYPE 1; COLLAGEN TYPE 1 ALPHA 1; COLLAGEN TYPE 1 ALPHA 2; COLLAGEN TYPE 3; COLLAGEN TYPE 3 ALPHA 1; COMPLEMENT COMPONENT C1Q; COMPLEMENT COMPONENT C1Q BETA; COMPLEMENT COMPONENT C1Q BETA ALPHA; CONNECTIVE TISSUE GROWTH FACTOR; CXCL9 CHEMOKINE; ENDOTHELIAL CELL GROWTH FACTOR; ENDOTHELIAL CELL GROWTH FACTOR 1; ERYTHROPOIETIN RECEPTOR; INTERFERON REGULATORY FACTOR 6; LAMININ; LAMININ BETA 1; LUMICAN; MACROPHAGE DERIVED CHEMOKINE; MONOCYTE TO MACROPHAGE DIFFERENTIATION ASSOCIATED PROTEIN; OSTEONECTIN; PROTEIN; THYMUS AND ACTIVATION REGULATED CHEMOKINE; TRANSCRIPTION FACTOR RUNX1; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGED; ARTICLE; BIOINFORMATICS; CANCER TISSUE; CELL INFILTRATION; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; EXTRACELLULAR MATRIX; FEMALE; FIBROBLAST; GENE EXPRESSION PROFILING; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFLAMMATION; LYMPH NODE BIOPSY; MACROPHAGE; MALE; MICROENVIRONMENT; MIXED CELLULARITY HODGKIN LYMPHOMA; NODULAR SCLEROSIS HODGKIN LYMPHOMA; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; TISSUE REPAIR; WOUND HEALING;

ADOLESCENT; ADULT; AGED; BIOLOGICAL MARKERS; EXTRACELLULAR MATRIX; FEMALE; FIBROSIS; GENE EXPRESSION PROFILING; HODGKIN DISEASE; HUMANS; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MALE; MIDDLE AGED; WOUND HEALING;

EID: 70349973447     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/sj.bjc.6605238     Document Type: Article

References (37)

1. Aldinucci D, Poletto D, Nanni P, Degan M, Gloghini A, Di Francia R, Russo S, Carbone A, Pinto A, Gattei V (2002) Hodgkin and Reed-Sternberg cells express functional c-kit receptors and interact with primary fibroblasts from Hodgkin's disease-involved lymph nodes through soluble and membrane-bound stem cell factor. Br J Haematol 118: 1055-1064
2. Axdorph U, Porwit-MacDonald A, Grimfors G, Bjorkholm M (2001) Tissue eosinophilia in relation to immunopathological and clinical characteristics in Hodgkin's disease. Leuk Lymphoma 42: 1055-1065
3. Axdorph U, Porwit-MacDonald A, Sjoberg J, Grimfors G, Ekman M, Wang W, Biberfeld P, Bjorkholm M (1999) Epstein-Barr virus expression in Hodgkin's disease in relation to patient characteristics, serum factors and blood lymphocyte function. Br J Cancer 81: 1182-1187
4. Baumforth KR, Birgersdotter A, Reynolds GM, Wei W, Kapatai G, Flavell JR, Kalk E, Piper K, Lee S, Machado L, Hadley K, Sundblad A, Sjoberg J, Bjorkholm M, Porwit AA, Yap LF, Teo S, Grundy RG, Young LS, Ernberg I, Woodman CB, Murray PG (2008) Expression of the Epstein-Barr Virus-encoded Epstein-Barr Virus nuclear antigen 1 in Hodgkin's lymphoma cells mediates up-regulation of CCL20 and the migration of regulatory T cells. Am J Pathol 173: 195-204
5. Bhogal RK, Stoica CM, McGaha TL, Bona CA (2005) Molecular aspects of regulation of collagen gene expression in fibrosis. J Clin Immunol 25: 592-603
6. Biswas SK, Gangi L, Paul S, Schioppa T, Saccani A, Sironi M, Bottazzi B, Doni A, Vincenzo B, Pasqualini F, Vago L, Nebuloni M, Mantovani A, Sica A (2006) A distinct and unique transcriptional program expressed by tumor-associated macrophages (defective NF-kappaB and enhanced IRF-3/STAT1 activation). Blood 107: 2112-2122
7. Brauninger A, Schmitz R, Bechtel D, Renne C, Hansmann ML, Kuppers R (2006) Molecular biology of Hodgkin's and Reed/Sternberg cells in Hodgkin's lymphoma. Int J Cancer 118: 1853-1861
8. Buttner C, Skupin A, Rieber EP (2004) Transcriptional activation of the type I collagen genes COL1A1 and COL1A2 in fibroblasts by interleukin-4: analysis of the functional collagen promoter sequences. J Cell Physiol 198: 248-258
9. Chiu A, Xu W, He B, Dillon SR, Gross JA, Sievers E, Qiao X, Santini P, Hyjek E, Lee JW, Cesarman E, Chadburn A, Knowles DM, Cerutti A (2007) Hodgkin lymphoma cells express TACI and BCMA receptors and generate survival and proliferation signals in response to BAFF and APRIL. Blood 109: 729-739
10. Coussens LM, Werb Z (2002) Inflammation and cancer. Nature 420: 860-867
11. Dave SS, Wright G, Tan B, Rosenwald A, Gascoyne RD, Chan WC, Fisher RI, Braziel RM, Rimsza LM, Grogan TM, Miller TP, LeBlanc M, Greiner TC, Weisenburger DD, Lynch JC, Vose J, Armitage JO, Smeland EB, Kvaloy S, Holte H, Delabie J, Connors JM, Lansdorp PM, Ouyang Q, Lister TA, Davies AJ, Norton AJ, Muller-Hermelink HK, Ott G, Campo E, Montserrat E, Wilson WH, Jaffe ES, Simon R, Yang L, Powell J, Zhao H, Goldschmidt N, Chiorazzi M, Staudt LM (2004) Prediction of survival in follicular lymphoma based on molecular features of tumor-infiltrating immune cells. N Engl J Med 351: 2159-2169
12. De Jong D, Koster A, Hagenbeek A, Raemaekers J, Veldhuizen D, Heisterkamp S, de Boer JP, van Glabbeke M (2009) Impact of the tumor microenvironment on prognosis in follicular lymphoma is dependent on specific treatment protocols. Haematologica 94: 70-77
13. Devilard E, Bertucci F, Trempat P, Bouabdallah R, Loriod B, Giaconia A, Brousset P, Granjeaud S, Nguyen C, Birnbaum D, Birg F, Houlgatte R, Xerri L (2002) Gene expression profiling defines molecular subtypes of classical Hodgkin's disease. Oncogene 21: 3095-3102
14. Eichler GS, Huang S, Ingber DE (2003) Gene Expression Dynamics Inspector (GEDI): for integrative analysis of expression profiles. Bioinformatics 19: 2321-2322
15. Enbom M, Strand A, Falk KI, Linde A (2001) Detection of Epstein-Barr virus, but not human herpesvirus 8, DNA in cervical secretions from Swedish women by real-time polymerase chain reaction. Sex Transm Dis 28: 300-306
16. Irizarry RA, Bolstad BM, Collin F, Cope LM, Hobbs B, Speed TP (2003) Summaries of Affymetrix GeneChip probe level data. Nucleic Acids Res 31: e15
17. Jaffe ES, Harris N, Stein H, Vardiman JW (2001) Pathology and Genetics of Tumours of Haematopoietic and Lymfoid Tissues: IARC Press:Lyon
18. Karube K, Ohshima K, Suzumiya J, Kawano R, Kikuchi M, Harada M (2006) Gene expression profile of cytokines and chemokines in microdissected primary Hodgkin and Reed-Sternberg (HRS) cells: high expression of interleukin-11 receptor alpha. Ann Oncol 17: 110-116
19. Kuppers R, Rajewsky K, Zhao M, Simons G, Laumann R, Fischer R, Hansmann ML (1994) Hodgkin disease: Hodgkin and Reed-Sternberg cells picked from histological sections show clonal immunoglobulin gene rearrangements and appear to be derived from B cells at various stages of development. Proc Natl Acad Sci USA 91: 10962-10966
20. Leek RD, Lewis CE, Whitehouse R, Greenall M, Clarke J, Harris AL (1996) Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma. Cancer Res 56: 4625-4629
21. Mantovani A, Sozzani S, Locati M, Allavena P, Sica A (2002) Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol 23: 549-555
22. Molin D, Edstrom A, Glimelius I, Glimelius B, Nilsson G, Sundstrom C, Enblad G (2002) Mast cell infiltration correlates with poor prognosis in Hodgkin's lymphoma. Br J Haematol 119: 122-124
23. Poppema S, van den Berg A (2000) Interaction between host T cells and Reed-Sternberg cells in Hodgkin lymphomas. Semin Cancer Biol 10: 345-350
24. Porta C, Subhra Kumar B, Larghi P, Rubino L, Mancino A, Sica A (2007) Tumor promotion by tumor-associated macrophages. Adv Exp Med Biol 604: 67-86
25. Provenzano PP, Alejandro-Osorio AL, Valhmu WB, Jensen KT, Vanderby Jr R (2005) Intrinsic fibroblast-mediated remodeling of damaged collage-nous matrices in vivo. Matrix Biol 23: 543-555
26. Re D, Kuppers R, Diehl V (2005) Molecular pathogenesis of Hodgkin's lymphoma. J Clin Oncol 23: 6379-6386
27. Renne C, Hinsch N, Willenbrock K, Fuchs M, Klapper W, Engert A, Kuppers R, Hansmann ML, Brauninger A (2007) The aberrant coexpression of several receptor tyrosine kinases is largely restricted to EBV-negative cases of classical Hodgkin's lymphoma. Int J Cancer 120: 2504-2509
28. Reynolds GM, Billingham LJ, Gray LJ, Flavell JR, Najafipour S, Crocker J, Nelson P, Young LS, Murray PG (2002) Interleukin 6 expression by Hodgkin/Reed-Sternberg cells is associated with the presence of 'B' symptoms and failure to achieve complete remission in patients with advanced Hodgkin's disease. Br J Haematol 118: 195-201
29. Sanchez-Aguilera A, Montalban C, de la Cueva P, Sanchez-Verde L, Morente MM, Garcia-Cosio M, Garcia-Larana J, Bellas C, Provencio M, Romagosa V, de Sevilla AF, Menarguez J, Sabin P, Mestre MJ, Mendez M, Fresno MF, Nicolas C, Piris MA, Garcia JF (2006) Tumor microenviron-ment and mitotic checkpoint are key factors in the outcome of classic Hodgkin lymphoma. Blood 108: 662-668
30. Shunyakov L, Ryan CK, Sahasrabudhe DM, Khorana AA (2004) The influence of host response on colorectal cancer prognosis. Clin Colorectal Cancer 4: 38-45
31. Sica A, Larghi P, Mancino A, Rubino L, Porta C, Totaro MG, Rimoldi M, Biswas SK, Allavena P, Mantovani A (2008) Macrophage polarization in tumour progression. Semin Cancer Biol 18(5): 349-355
32. Skinnider BF, Elia AJ, Gascoyne RD, Patterson B, Trumper L, Kapp U, Mak TW (2002) Signal transducer and activator of transcription 6 is frequently activated in Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma. Blood 99: 618-626
33. Skinnider BF, Elia AJ, Gascoyne RD, Trumper LH, von Bonin F, Kapp U, Patterson B, Snow BE, Mak TW (2001) Interleukin 13 and interleukin 13 receptor are frequently expressed by Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma. Blood 97: 250-255
34. Teruya-Feldstein J, Jaffe ES, Burd PR, Kingma DW, Setsuda JE, Tosato G (1999) Differential chemokine expression in tissues involved by Hodgkin's disease: direct correlation of eotaxin expression and tissue eosinophilia. Blood 93: 2463-2470
35. Trieu Y, Wen XY, Skinnider BF, Bray MR, Li Z, Claudio JO, Masih-Khan E, Zhu YX, Trudel S, McCart JA, Mak TW, Stewart AK (2004) Soluble interleukin-13Ralpha2 decoy receptor inhibits Hodgkin's lymphoma growth in vitro and in vivo. Cancer Res 64: 3271-3275
36. Tusher VG, Tibshirani R, Chu G (2001) Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci USA 98: 5116-5121
37. Weinberg RA (ed) (2007) The biology of cancer. Garland Science, Taylor and Francis Group, LLC: New York.