DKC1 overexpression associated with prostate cancer progression

British Journal of Cancer

Volumn 101, Issue 8, 2009, Pages 1410-1416

  Sieron, P ^a   Hader, C ^a   Hatina, J ^a   Engers, R ^a   Wlazlinski, A ^a   Muller M ^a   Schulz, W A ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Apoptosis; Dyskerin; Prostate adenocarcinoma; SiRNA; Telomerase; Tumour progression

Indexed keywords

DYSKERIN; HTR PROTEIN; MK 167 PROTEIN; PROTEIN; SMALL INTERFERING RNA; TELOMERASE; TUMOR NECROSIS FACTOR ALPHA; TUNICAMYCIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER RECURRENCE; CARCINOGENESIS; CARCINOMA CELL; CELL ADHESION; CELL AGING; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; MALE; PHENOTYPE; PRIORITY JOURNAL; PROSTATE CARCINOMA; PROTEIN SYNTHESIS; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION;

APOPTOSIS; CELL CYCLE PROTEINS; CELL LINE, TUMOR; DISEASE PROGRESSION; HUMANS; MALE; NUCLEAR PROTEINS; PROSTATIC NEOPLASMS; RNA, MESSENGER; RNA, SMALL INTERFERING; TELOMERASE;

EID: 70349964672     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/sj.bjc.6605299     Document Type: Article

References (21)

1. Alawi F, Lee MN (2007) DKC1 is a direct and conserved transcriptional target of c-MYC. Biochem Biophys Res Commun 362: 893-898
2. Bettendorf O, Heine B, Kneif S, Eltze E, Semjonow A, Herbst H, Stein H, Böcker W, Poremba C (2003) Expression-patterns of the RNA component (hTR)and the catalytic subunit (hTERT) of human telomerase in nonneoplastic prostate tissue, prostatic intraepithelial neoplasia, and prostate cancer. Prostate 55: 99-104
3. Chang JTC, Chen YL, Yang HT, Chen CY, Cheng AJ (2002) Differential regulation of telomerase activity by six telomerase subunits. Eur J Biochem 269: 3442-3450
4. Cohen SB, Graham ME, Lovrecz GO, Bache N, Robinson PJ, Reddel RR (2007) Protein composition of catalytically active human telomerase from immortal cells. Science 315: 1850-1853
5. Dimri GP, Lee X, Basile G, Acosta M, Scott G, Roskelley C, Medrano EE, Linskens M, Rubelj I, Pereira-Smith O, Peacocke M, Campisi J (1995) A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA 92: 9363-9367
6. Filipowicz W, Pogacic V (2002) Biogenesis of small nucleolar ribonucleo-proteins. Curr Opin Cell Biol 14: 319-327
7. Gu BW, Bessler M, Mason PJ (2008) A pathogenic dyskerin mutation impairs proliferation and activates a DNA damage response independent of telomere length in mice. Proc Natl Acad Sci USA 105: 10173-10178
8. Guo C, Geverd D, Liao R, Hamad N, Counter CM, Price DT (2001) Inhibition of telomerase is related to the life span and tumorigenicity of human prostate cancer cells. J Urol 166: 694-698
9. Kamradt J, Drosse C, Kalkbrenner S, Rohde V, Lensch R, Lehmann J, Fixemer T, Bonkhoff H, Stoeckle M, Wullich B (2003) Telomerase activity and telomerase subunit gene expression levels are not related in prostate cancer: a real-time quantification and in situ hybridisation study. Lab Invest 83: 623-631
10. Kirwan M, Dokal I (2008) Dyskeratosis congenita: a genetic disorder of many faces. Clin Genet 73: 103-112
11. Mason PJ, Wilson DB, Bessler M (2005) Dyskeratosis congenita-a disease of dysfunctional telomere maintenance. Curr Mol Med 5: 159-170
12. Montanaro L, Bigotti M, Clohessy J, Barbieri S, Ceccarelli C, Santini D, Taufurelli M, Calienti M, Teruya-Feldstein J, Trere D, Pandolfi PP, Derenzini M (2006) Dyskerin expression influences the level of ribosomal RNA pseudo-uridylation and telomerase RNA component in human breast cancer. J Pathol 210: 10-18
13. Montanaro L, Calienni M, Ceccarelli C, Santini D, Taffurelli M, Plileri S, Treré D, Derenzini M (2008a) Relationship between dyskerin expression and telomerase activity in human breast cancer. Cell Oncol 30: 483-490
14. Montanaro L, Treré D, Derenzini M (2008b) Nucleolus, ribosomes, and cancer. Am J Pathol 173: 301-310
15. Poncet D, Belleville A, de Roodenbeke C, de Climens AR, Ben Simon E, Merle-Beral H, Callet-Bauchu E, Salles G, Sabatier L, Delic J, Gilson E (2008) Changes in the expression of telomere maintenance genes suggest global telomere dysfunction in B-chronic lymphocytic leukaemia. Blood 111: 2388-2391
16. Schmidt U, Fuessel S, Koch R, Baretton GB, Lohse A, Tomasetti S, Unversucht S, Froehner M, Wirth MP, Meye A (2006) Quantitative multi-gene expression profiling of primary prostate cancer. Prostate 66: 1521-1534
17. Schulz WA, Alexa A, Jung V, Hader C, Hoffmann MJ, Yamanaka M, Fritzsche S, Wlazlinski A, Müller M, Lengauer T, Engers R, Florl AR, Wullich B, Rahnenführer J (2007) Factor interaction analysis for chromosome 8 and DNA methylation alterations highlights innate immune response suppression and cytoskeletal changes in prostate cancer. Mol Cancer 6: 14
18. Shiraishi T, Yoshida T, Nakata S, Horinaka M, Wakada M, Mizutani Y, Miki T, Sakai T (2005) Tunicamycin enhances tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human prostate cancer cells. Cancer Res 65: 6364-6370
19. Wlazlinski A, Engers R, Hoffmann MJ, Hader C, Jung V, Müller M, Schulz WA (2007) Downregulation of several fibulin genes in prostate cancer. Prostate 67: 1770-1780
20. Wong JMY, Collins K (2006) Telomerase RNA level limits telomere maintenance in X-linked dyskeratosis congenital. Genes Dev 20: 2848-2858
21. Yoon A, Peng G, Brandenburg Y, Zollo O, Xu W, Rego E, Ruggero D (2006) Impaired control of IRES-mediated translation in X-linked dyskeratosis congenita. Science 312: 902-906