Gender-related difference in the toxicity of 2-(2′-hydroxy-3′, 5′-di-tert-butylphenyl)benzotriazole in rats: Relationship to the plasma concentration, in vitro hepatic metabolism, and effects on hepatic metabolizing enzyme activity

Drug and Chemical Toxicology

Volumn 32, Issue 3, 2009, Pages 204-214

  Hirata Koizumi, Mutsuko ^a   Matsuno, Kiyomi ^b   Kawabata, Mitsuhiko ^b   Yajima, Kanako ^b   Matsuyama, Takashi ^b   Hirose, Akihiko ^a   Kamata, Eiichi ^a   Ema, Makoto ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^b SHIN NIPPON BIOMEDICAL LABORATORIES LTD   (Japan)

Author keywords

Benzotriazole UV absorber; Gender related difference; Hepatic metabolizing enzyme activity; In vitro hepatic metabolism; Plasma concentration; Rat

Indexed keywords

2 (2' HYDROXY 3',5' DI TERT BUTYLPHENYL)BENZOTRIAZOLE; AMINOPYRINE N DEMETHYLASE; BENZENE DERIVATIVE; BENZOTRIAZOLE DERIVATIVE; CYTOCHROME P450; ETHOXYRESORUFIN DEETHYLASE; HYDROXYL GROUP; LAURIC ACID 12 HYDROXYLASE; MIXED FUNCTION OXIDASE; OXYGENASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; STEROID 16ALPHA MONOOXYGENASE; TESTOSTERONE 2ALPHA HYDROXYLASE; UNCLASSIFIED DRUG; 2 (2' HYDROXY 3',5' DI TERT BUTYLPHENYL) BENZOTRIAZOLE; 2-(2'-HYDROXY-3',5'-DI-TERT-BUTYLPHENYL) BENZOTRIAZOLE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE FERRIHEMOPROTEIN REDUCTASE; RIBOSOMAL PROTEIN S9; RIBOSOME PROTEIN; TRIAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; GENDER; IN VITRO STUDY; LIQUID CHROMATOGRAPHY; LIVER METABOLISM; LIVER MICROSOME; MALE; METABOLITE; NONHUMAN; PEROXISOME; RAT; TANDEM MASS SPECTROMETRY; ANIMAL; BODY WEIGHT; COMPARATIVE STUDY; DRUG EFFECT; ENZYMOLOGY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIVER; METABOLISM; ORAL DRUG ADMINISTRATION; PATHOLOGY; SEX DIFFERENCE; SPRAGUE DAWLEY RAT; TOXICITY TESTING;

RATTUS;

ADMINISTRATION, ORAL; ANIMALS; BODY WEIGHT; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEMALE; LIVER; MALE; MICROSOMES, LIVER; NADPH-FERRIHEMOPROTEIN REDUCTASE; RATS; RATS, SPRAGUE-DAWLEY; RIBOSOMAL PROTEINS; SEX FACTORS; TANDEM MASS SPECTROMETRY; TOXICITY TESTS; TRIAZOLES;

EID: 70349904648     PISSN: 01480545     EISSN: 15256014     Source Type: Journal    
DOI: 10.1080/01480540902862244     Document Type: Article

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