Understanding organic nitrates - a vein hope?

British Journal of Pharmacology

Volumn 157, Issue 4, 2009, Pages 565-567

  Miller, Mark R ^a,c   Wadsworth, Roger M ^b  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF STRATHCLYDE   (United Kingdom)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Ascorbate deficiency; Glyceryl trinitrate; Mitochondrial aldehyde dehydrogenase; Nitric oxide; Nitroglycerin; Tolerance

Indexed keywords

ALDEHYDE DEHYDROGENASE ISOENZYME 2; ASCORBIC ACID; GLYCEROL 1,2 DINITRATE; GLYCERYL TRINITRATE; ISOSORBIDE DINITRATE; ISOSORBIDE MONONITRATE; LA 419; NITRIC OXIDE; ORGANIC NITRATE; OXYGEN RADICAL; SCAVENGER; UNCLASSIFIED DRUG; ALDEHYDE DEHYDROGENASE; NITRATE; VASODILATOR AGENT;

ANGINA PECTORIS; ARTERY DILATATION; ASCORBIC ACID DEFICIENCY; CLINICAL EFFECTIVENESS; DRUG ACTIVITY; DRUG EFFECT; DRUG RESPONSE; DRUG TOLERANCE; ENZYME ACTIVITY; GUINEA PIG; NONHUMAN; NOTE; PRIORITY JOURNAL; SPECIES; VASODILATATION; VEIN DILATATION; ANIMAL; ARTICLE; BIOSYNTHESIS; BLOOD; DRUG ANTAGONISM; METABOLISM; MITOCHONDRION;

ALDEHYDE DEHYDROGENASE; ANGINA PECTORIS; ANIMALS; ASCORBIC ACID; DRUG TOLERANCE; MITOCHONDRIA; NITRATES; NITRIC OXIDE; NITROGLYCERIN; VASODILATOR AGENTS;

EID: 70349900608     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2009.00193.x     Document Type: Note

References (12)

1. Chen Z, Zhang J, Stamler JS (2002). Identification of the enzymatic mechanism of nitroglycerin bioactivation. Proc Natl Acad Sci USA 99: 8306-8311. (Pubitemid 34651048)
2. Daiber A, Oelze M, Coldewey M, Bachschmid M, Wenzel P, Sydow K et al. (2004). Oxidative stress and mitochondrial aldehyde dehydrogenase activity: a comparison of pentaerythritol tetranitrate with other organic nitrates. Mol Pharmacol 66: 1372-1382. (Pubitemid 39564764)
3. Daiber A, Wenzel P, Oelze M, Schuhmacher S, Jansen T, Munzel T (2009). Mitochondrial aldehyde dehydrogenase (ALDH-2)-Maker of and marker for nitrate tolerance in response to nitroglycerin treatment. Chem Biol Interact 178: 40-47.
4. Kleschyov AL, Oelze M, Daiber A, Huang Y, Mollnau H, Schulz E et al. (2003). Does nitric oxide mediate the vasodilator activity of nitroglycerin? Circ Res 93: e104-e112.
5. Mayer B, Beretta M (2008). The enigma of nitroglycerin bioactivation and nitrate tolerance: news, views and troubles. Br J Pharmacol 155: 170-184.
6. Miller MR, Megson IL (2007). Recent developments in nitric oxide donor drugs. Br J Pharmacol 151: 305-321.
7. Miller MR, Grant S, Wadsworth RM (2008). Selective arterial dilatation by glyceryl trinitrate is not associated with NO formation in vitro. J Vasc Res 45: 375-385.
8. Munzel T, Sayegh H, Freeman BA, Tarpey MM, Harrison DG (1995). Evidence for enhanced vascular superoxide anion production in nitrate tolerance. A novel mechanism underlying tolerance and cross-tolerance. J Clin Invest 95: 187-194.
9. Nunez C, Victor VM, Tur R, Alvarez-Barrientos A, Moneada S, Esplugues JV et al. (2005). Discrepancies between nitroglycerin and NO-releasing drugs on mitochondrial oxygen consumption, vasoactivity, and the release of NO. Circ Res 97: 1063-1069. (Pubitemid 41668920)
10. Ruiz-Hurtado G, Fernández-Velasco M, Mourelle M, Delgado C (2007). LA419, a novel nitric oxide donor, prevents pathological cardiac remodeling in pressure-overloaded rats via endothelial nitric oxide synthase pathway regulation. Hypertension 50: 1049-1056.
11. Wenzl MV, Wolkart G, Stessel H, Beretta M, Schmidt K, Mayer B (2009). Different effects of ascorbate deprivation and classical vascular nitrate tolerance on aldehyde dehydrogenase-catalysed bioactivation of nitroglycerin. Br J Pharmacol 156: 1248-1255.
12. Wolkart G, Wenzl MV, Beretta M, Stessel H, Schmidt K, Mayer B (2008). Vascular tolerance to nitroglycerin in ascorbate deficiency. Cardiovasc Res 79: 304-312. (Pubitemid 351951613)