Macrocyclization by nickel-catalyzed, ester-promoted, epoxide-alkyne reductive coupling: Total synthesis of (-)-gloeosporone

Angewandte Chemie - International Edition

Volumn 48, Issue 29, 2009, Pages 5366-5368

  Trenkle, James D ^a,b   Jamison, Timothy F ^a,b  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b GILEAD SCIENCES   (United States)

Author keywords

C C coupling; Cyclization; Nickel; Reductive coupling; Total synthesis

Indexed keywords

C-C BOND FORMATION; C-C COUPLING; MACRO-CYCLIZATION; NOVEL STRATEGIES; PHOSPHINE COMPLEX; REDUCTIVE COUPLING; REDUCTIVE COUPLINGS; TITLE COMPOUNDS; TOTAL SYNTHESIS;

ACETYLENE; CYCLIZATION; ESTERS; NICKEL; NICKEL ALLOYS; PHOSPHORUS COMPOUNDS;

COMPLEXATION;

ALKYNE; BORANE DERIVATIVE; EPOXIDE; GLOEOSPORONE; LACTONE; NICKEL; PHOSPHINE; PHOSPHINE DERIVATIVE; TRIETHYLBORANE;

CATALYSIS; CHEMISTRY; CYCLIZATION; OXIDATION REDUCTION REACTION; STEREOISOMERISM; SYNTHESIS;

ALKYNES; BORANES; CATALYSIS; CYCLIZATION; EPOXY COMPOUNDS; LACTONES; NICKEL; OXIDATION-REDUCTION; PHOSPHINES; STEREOISOMERISM;

EID: 70349900286     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200902079     Document Type: Article

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