Stimulation of lymphocyte anti-melanoma activity by co-cultured macrophages activated by complex homeopathic medication

BMC Cancer

Volumn 9, Issue , 2009, Pages 293-

  Guimarães, Fernando S F ^a   Abud, Ana P R ^a   Oliveira, Simone M ^a   Oliveira, Carolina C ^a   César, Beatriz ^a   Andrade, Lucas F ^a   Donatti, Lucélia ^a   Gabardo, Juarez ^a   Trindade, Edvaldo S ^a   Buchi, Dorly F ^a  

^a FEDERAL UNIVERSITY OF PARANÁ   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ACONITUM NAPELLUS EXTRACT; ARSENIC; PLANT EXTRACT; SILICON DIOXIDE; SULFUR; THUYA OCCIDENTALIS EXTRACT; UNCLASSIFIED DRUG;

ACONITUM; ACONITUM NAPELLUS; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CD25+ T LYMPHOCYTE; CELL DENSITY; CELL DESTRUCTION; CELL LINEAGE; CELL VIABILITY; CLINICAL EFFECTIVENESS; COCULTURE; CONTROLLED STUDY; HOMEOPATHY; IMMUNE RESPONSE; IMMUNOMODULATION; IN VITRO STUDY; LYMPH NODE; LYMPHOCYTE ACTIVATION; LYMPHOCYTE CULTURE; MACROPHAGE ACTIVATION; MALE; MEDICINAL PLANT; MELANOMA; MELANOMA CELL; MOUSE; NONHUMAN; THUYA OCCIDENTALIS; TUMOR CELL DESTRUCTION;

ANIMALS; CELL LINE, TUMOR; CELLS, CULTURED; COCULTURE TECHNIQUES; CYTOTOXICITY, IMMUNOLOGIC; LYMPHOCYTES; MACROPHAGE ACTIVATION; MACROPHAGES; MALE; MATERIA MEDICA; MELANOMA; MICE;

EID: 70349878349     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-9-293     Document Type: Article

References (31)

1. Rigel DS, Carucci JA. Malignant melanoma: Prevention, early detection, and treatment in the 21st Century. CA: Cancer Journal of Clinics 2000, 50:215-236. 10.3322/canjclin.50.4.215.
2. Thompson JF, Scolyer RA, Kefford RF. Cutaneous melanoma. Lancet 2005, 365:687-701.
3. Milazzo S, Russell N, Ernst E. Efficacy of homeopathic therapy in cancer treatment. European Journal of Cancer 2006, 42:282-289. 10.1016/j.ejca.2005.09.025, 16376071.
4. Piemonte MR, Buchi DF. Analysis of IL-12, IFN-g and TNF-alpha production, α5 β1 integrins and actin filaments distribution in peritoneal mouse macrophages treated with homeopathic medicament. Journal of Submicroscopical Cytology and Pathology 2002, 33(4):255-263.
5. Oliveira CC, Oliveira SM, Godoy LMF, Gabardo J, Buchi DF. Canova, a Brazilian medical formulation, alters oxidative metabolism of mice macrophages. Journal of Infection 2006, 52:420-432. 10.1016/j.jinf.2005.08.017, 16386798.
6. Lopes L, Godoy LMF, De Oliveira CC, Gabardo J, Schadeck RJG, Buchi DF. Phagocytosis, endosomal/lisosomal system and other cellular aspects of macrophage activation by Canova medication. Micron 2006, 37:277-287. 10.1016/j.micron.2005.08.005, 16364649.
7. Pereira WKV, Lonardoni MVC, Grespan R, Caparroz-Assef SM, Cuman RKN, Bersani-Amado CA. Immunomodulatory effect of Canova medication on experimental Leishmania amazonensis infection. Journal of Infection 2005, 51(2):157-164. 10.1016/j.jinf.2004.09.009, 16038768.
8. Takahachi G, Maluf MLF, Svidzinski, Dalalio MMO, Bersani-Amado CA, Cuman RKN. In vivo and in vitro effects of the Canova medicine on experimental infection with Paracoccidioides brasiliensis in mice. Indian Journal of Pharmacology 2006, 38(5):350-354.
9. Oliveira CC, de Oliveira SM, Goes VM, Probst CM, Krieger MA, Buchi DF. Gene expression profiling of macrophages following mice treatment with an immunomodulator medication. Journal of Cellular Biochemistry 2008, 104:1364-1377. 10.1002/jcb.21713, 18286468.
10. Seligmann IC, Lima PD, Cardoso PC, Khayat AS, Bahia MO, Buchi DF, Cabral IR, Burbano RR. The anticancer homeopathic composite "Canova Method" is not genotoxic for human lymphocytes in vitro. Genetics and Molecular Research 2003, 2:223-228.
11. Sato DYO, Wal R, De Oliveira CC, Cattaneo RII, Malvezzi M, Gabardo J, Buchi DF. Histopathological and immunophenotyping studies on normal and sarcoma 180-bearing mice treated with a Brazilian homeopathic medication. Homeopathy 2005, 94(1):26-32. 10.1016/j.homp.2004.10.003, 15751331.
12. Abud APR, César B, Cavazzani LFM, De Oliveira CC, Gabardo J, Buchi DF. Activation of bone marrow cells treated with Canova in vitro. Cell Biology International 2006, 30(10):808-816. 10.1016/j.cellbi.2006.06.011, 16884931.
13. Cesar B, Abud APR, De Oliveira CC, Cardoso F, Gremski W, Gabardo J, Buchi DF. Activation of mononuclear bone marrow cells treated in vitro with a complex homeopathic medication. Micron 2008, 39(4):461-470. 10.1016/j.micron.2007.02.005, 17379529.
14. Buchi DF, de Souza W. Internalization of surface components during ingestion of Saccaromyces cerevisiae by macrophage. Journal of Submicroscopical Cytology and Pathology 1992, 24(1):135-141.
15. Buchi DF, de Souza W. Internalization of surface components during Fc-receptor mediated phagocytosis by macrophages. Cell Structure and Function 1993, 18:399-407.
16. Dudley EM, Wunderlich JR, Robbins PF, Yang JC. Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes. Science 2002, 298:850-854. 10.1126/science.1076514, 1764179, 12242449.
17. Pascual CF, Vicente OV, Campos AM, Yañez GJ. In vivo treatment of melanoma (B16F10) with a homeopathic agent and with a cytokine (IFN-α). Oncology Research 2006, 16(5):211-216. 17294801.
18. Rahman A, Bukhsh K. Towards understanding molecular mechanisms of action of homeopathic drugs: An overview. Molecular and Cellular Biochemistry 2003, 253:339-345. 10.1023/A:1026048907739, 14619985.
19. McGill GG, Horstmann M, Widlung HR, Du J, Motyckowa G, Nishimura EK, Lin Y, Ramaswamy S, Avery W, Ding H, Jordan SA, Jackson IJ, Korsmeyer SJ, Golub TR, Fisher DE. Bcl2 regulation by the melanocyte master regulator mitf modulates lineage survival and melanoma cell viability. Cell 2002, 109:707-718. 10.1016/S0092-8674(02)00762-6, 12086670.
20. Griffioen M, Kessler JH, Borghi M, Soest RA. Detection and functional analysis of CD8+ TCells specific for PRAME: a target for T-cell therapy. Clinical Cancer Research 2006, 12(10):3130-3136. 10.1158/1078-0432.CCR-05-2578, 16707612.
21. Clarke JH, Cha JY, Walsh MD, Gamboni-Robertson F, Banerjee A, Reznikow LL, Dinarello CA, Harken AH, McCarter MD. Melanoma inhibits macrophage activation by suppressing toll-like receptor 4 signaling. Journal of American College Surgeon 2005, 201(3):418-425.
22. Liu YJ, Kanzler H, Soumelis V, Gilliet M. (2001) Dentritic cell lineage, plasticity and cross-regulation. Nature Immunology 2001, 2(7):585-589. 10.1038/89726, 11429541.
23. Gordon S. Alternative activation on macrophages. Nature Reviews - Immunology 2003, 3:23-35. 10.1038/nri978, 12511873.
24. Demeure CE, Wolfersc J, Martin-Garcia N, Gaulard P, Triebel FT. Lymphocytes infiltrating various tumor types express the MHC class II ligand lymphocyte activation gene-3 (LAG-3): role of LAG-3/MHC class II interactions in cell-cell contacts. European Journal of Cancer 2001, 37:1709-1718. 10.1016/S0959-8049(01)00184-8, 11527700.
25. Boon T, Pierre G, Coulie-Benoit J, Eynde V, Bruggen P. Human T cell responses against melanoma. Annual Review in Immunolology 2006, 24:175-208. 10.1146/annurev.immunol.24.021605.090733.
26. Liwski RS, Chase JC, Baldrige WH, Sadek I. Prolonged coestimulation is required for naïve T cell activation. Immunology Letters 2006, 106:135-143. 10.1016/j.imlet.2006.05.003, 16769127.
27. Lanzavecchia A, Sallusto F. Antigen decoding by T lymphocytes: From synapses to fate determination. Nature Immunology 2001, 2:487-492. 10.1038/88678, 11376334.
28. Fehniger TA, Cooper MA, Caligiuri MA. Interleukin-2 and interleukin- 15: immunotherapy for cancer. Cytokine and Grown Factor Reviews 2002, 13(2):169-183.
29. Watford WT, Moriguchi M, Morinobu A, O'Shea JJ. The biology of IL-12: coordinating innate and adaptive immune responses. Cytokine & Growth Factor Reviews 2003, 5:361-368.
30. Trapani JA. Tumor-mediated apoptosis of cancer-specific T lymphocytes - Reversing the "kiss of death"?. Cancer Cell 2002, 2(3):169-171. 10.1016/S1535-6108(02)00130-7, 12242147.
31. Szlosarek P, Charles KA, Balkwill FR. Tumor necrosis factor-α as a tumor promoter. European Journal of Cancer 2006, 42:745-750. 10.1016/j.ejca.2006.01.012, 16517151.