Adenovirus virion stability and the viral genome: Size matters

Molecular Therapy

Volumn 17, Issue 10, 2009, Pages 1664-1666

  Kennedy, Michael A ^a,b   Parks, Robin J ^a,b  

^a OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF OTTAWA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; CAPSID PROTEIN; VIRUS DNA;

ADENO ASSOCIATED VIRUS; ADENOVIRUS; ARTICLE; BACTERIOPHAGE LAMBDA; DNA PACKAGING; GENE VECTOR; GENETIC STABILITY; GENOME SIZE; HELPER VIRUS; INVERTED TERMINAL REPEAT; NONHUMAN; PROTEIN DNA INTERACTION; PROTEIN FUNCTION; STRUCTURE ANALYSIS; THERMOSTABILITY; VIRAL GENE DELIVERY SYSTEM; VIRION; VIRUS CAPSID; VIRUS GENOME; VIRUS PARTICLE;

ADENOVIRIDAE;

EID: 70349863387     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2009.202     Document Type: Note

References (34)

1. Russell, WC (2009). Adenoviruses: Update on structure and function. J Gen Virol 90: 1-20.
2. Fabry, CM, Rosa-Calatrava, M, Conway, JF, Zubieta, C, Cusack, S, Ruigrok, RW et al. (2005). A quasiatomic model of human adenovirus type 5 capsid. EMBO J 24: 1645-1654.
3. Maizel, JV Jr, White, DO and Scharff, MD (1968). The polypeptides of adenovirus. II. Soluble proteins, cores, top components and the structure of the virion. Virology 36: 126-136.
4. Russell, WC, Laver, WG and Sanderson, PJ (1968). Internal components of adenovirus. Nature 219: 1127-1130.
5. 32P-labelled in vivo. J Mol Biol 188: 23-37.
6. Mirza, MA and Weber, J (1982). Structure of adenovirus chromatin. Biochim Biophys Acta 696: 76-86.
7. Brown, DT, Westphal, M, Burlingham, BT, Winterhoff, U and Doerfler, W (1975). Structure and composition of the adenovirus type 2 core. J Virol 16: 366-387.
8. Newcomb, WW, Boring, JW and Brown, JC (1984). Ion etching of human adenovirus 2: Structure of the core. J Virol 51: 52-56.
9. Everitt, E, Sundquist, B, Pettersson, U and Philipson, L (1973). Structural proteins of adenoviruses. X. Isolation and topography of low molecular weight antigens from the virion of adenovirus type 2. Virology 52: 130-147.
10. Everitt, E, Lutter, L and Philipson, L (1975). Structural proteins of adenoviruses. XII. Location and neighbor relationship among proteins of adenovirion type 2 as revealed by enzymatic iodination, immunoprecipitation and chemical cross-linking. Virology 67: 197-208.
11. Chatterjee, PK, Vayda, ME and Flint, SJ (1985). Interactions among the three adenovirus core proteins. J Virol 55: 379-386.
12. Stewart, PL, Fuller, SD and Burnett, RM (1993). Difference imaging of adenovirus: Bridging the resolution gap between X-ray crystallography and electron microscopy. EMBO J 12: 2589-2599.
13. Silvestry, M, Lindert, S, Smith, JG, Maier, O, Wiethoff, CM, Nemerow, GR et al. (2009). Cryoelectron microscopy structure of adenovirus type 2 temperature-sensitive mutant 1 reveals insight into the cell entry defect. J Virol 83: 7375-7383.
14. Bett, AJ, Prevec, L and Graham, FL (1993). Packaging capacity and stability of human adenovirus type 5 vectors. J Virol 67: 5911-5921.
15. Mizuguchi, H, Funakoshi N, Hosono, T, Sakurai, F, Kawabata, K, Yamaguchi, T et al. (2007). Rapid construction of small interfering RNA-expressing adenoviral vectors on the basis of direct cloning of short hairpin RNA-coding DNAs. Hum Gene Ther 18: 74-80.
16. Palmer, DJ and Ng, P (2005). Helper-dependent adenoviral vectors for gene therapy. Hum Gene Ther 16: 1-16.
17. Parks, RJ, Chen, L, Anton, M, Sankar, U, Rudnicki, MA and Graham, FL (1996). A helper-dependent adenovirus vector system: Removal of helper virus by Cre-mediated excision of the viral packaging signal. Proc Natl Acad Sci U S A 93: 13565-13570.
18. Parks, RJ and Graham, FL (1997). A helper-dependent system for adenovirus vector production helps define a lower limit for efficient DNA packaging. J Virol 71: 3293-3298.
19. Sargent, K, Ng, P, Evelegh, C, Graham, FL and Parks, RJ (2004). Development of a size restricted pIX deleted helper virus for amplification of helper dependent adenovirus vectors. Gene Ther 11: 504-511.
20. Colby, WW and Shenk, T (1981). Adenovirus type 5 virions can be assembled in vivo in the absence of detectable polypeptide IX. J Virol 39: 977-980.
21. Parks, RJ (2005). Adenovirus protein IX: A new look at an old protein. Mol Ther 11: 19-25.
22. Smith, AC, Poulin, KL and Parks, RJ (2009). DNA genome size affects the stability of the adenovirus virion. J Virol 83: 2025-2028.
23. Lieber, A, He, CY, Kirillova, I and Kay, MA (1996). Recombinant adenoviruses with large deletions generated by Cre-mediated excision exhibit different biological properties compared with first-generation vectors in vitro and in vivo. J Virol 70: 8944-8960.
24. Shayakhmetov, DM, Li, ZY, Gaggar, A, Gharwan, H, Ternovoi, V, Sandig, V et al. (2004). Genome size and structure determine efficiency of postinternalization steps and gene transfer of capsid-modified adenovirus vectors in a cell-type-specific manner. J Virol 78 10009-10022.
25. Nurmemmedov, E, Castelnovo, M, Catalano, CE and Evilevitch, A (2007). Biophysics of viral infectivity: Matching genome length with capsid size. Q Rev Biophys 40: 327-356.
26. Ivanovska, I, Wuite, G, Jonsson, B and Evilevitch, A (2007). Internal DNA pressure modifies stability of WT phage. Proc Natl Acad Sci U S A 104: 9603-9608.
27. Carrasco, C, Carreira, A, Schaap, IA, Serena, PA, Gómez-Herrero, J, Mateu, MG et al. (2006). DNA-mediated anisotropic mechanical reinforcement of a virus. Proc Natl Acad Sci U S A 103: 13706-13711.
28. Li, T, Chen, Z, Johnson, JE and Thomas, GJ Jr (1992). Conformations, interactions, and thermostabilities of RNA and proteins in bean pod mottle virus: Investigation of solution and crystal structures by laser Raman spectroscopy. Biochemistry 31: 6673-6682.
29. Da Poian, AT, Johnson, JE and Silva, JL (2002). Protein-RNA interactions and virus stability as probed by the dynamics of tryptophan side chains. J Biol Chem 277: 47596-47602.
30. Michel, JP, Ivanovka, IL, Gibbons, MM, Klug, WS, Knobler, CM, Wuite, GJ et al. (2006). Nanoindentation studies of full and empty viral capsids and the effects of capsid protein mutations on elasticity and strength. Proc Natl Acad Sci U S A 103: 6184-6189.
31. Tzlil, S, Kindt, JT, Gelbart, WM and Ben-Shaul, A (2003). Forces and pressures in DNA packaging and release from viral capsids. Biophys J 84: 1616-1627.
32. Fejer, G, et al. (2008). Key role of splenic myeloid DCs in the IFN-alphabeta response to adenoviruses in vivo. PLoS Pathog 4 e1000208.
33. Nam, HJ, Lane, MD, Padron, E, Gurda, B, McKenna, R, Kohlbrenner, E et al. (2007). Structure of adenoassociated virus serotype 8, a gene therapy vector. J Virol 81: 12260-12271.
34. Govindasamy, L, Padron, E, McKenna, R, Muzyczka, N, Kaludov, N, Chiorini, JA et al. (2006). Structurally mapping the diverse phenotype of adeno-associated virus serotype 4. J Virol 80: 11556-11570.