Antioxidants in the prevention of atherosclerosis: The importance of proper patient selection

Clinical Nutrition

Volumn 28, Issue 5, 2009, Pages 581-582

  Levy, Yishai ^a   Blum, Shany ^a   Levy, Andrew P ^a  

^a RAMBAM MEDICAL CENTER   (Israel)

Author keywords

Antioxidants; Atherosclerosis; Haptoglobin; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; HAPTOGLOBIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; PLACEBO;

ARTICLE; ATHEROSCLEROSIS; CARDIOVASCULAR DISEASE; CLINICAL TRIAL; DIABETES MELLITUS; DIET SUPPLEMENTATION; GENOTYPE; HEART INFARCTION; HUMAN; MEDICAL RESEARCH; METHODOLOGY; MORBIDITY; MORTALITY; OXIDATIVE STRESS; PATIENT SELECTION; PHARMACOGENOMICS; TREATMENT OUTCOME;

EID: 70349792834     PISSN: 02615614     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clnu.2009.04.012     Document Type: Note

References (6)

1. Katsiki N., and Manes C. Is there a role for supplemented antioxidants in the prevention of atherosclerosis?. Clin Nutr 28 (2009) 3-9
2. Stephens N.G., Parsons A., Schofield P.M., Kelly F., Cheeseman K., and Mitchinson M.J. Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS). Lancet 347 (1996) 781-786
3. Boaz M., Smetana S., Weinstein T., Matas Z., Gafter U., Laina A., et al. Secondary prevention with antioxidants of cardiovascular disease in endstage renal disease (SPACE): randomised placebo-controlled trial. Lancet 356 (2000) 1213-1218
4. Milman U., Blum S., Shapira C., Aronson D., Miller-Lotan R., Anbinder Y., et al. Vitamin E supplementation reduces cardiovascular events in a subgroup of middle-aged individuals with both type 2 diabetes mellitus and the haptoglobin 2-2 genotype: a prospective double-blinded clinical trial. Arterioscler Thromb Vasc Biol 28 (2008) 341-347
5. Blum S., Milman U., Shapira C., Miller-Lotan R., Bennett L., Kostenko M., et al. Dual therapy with statins and antioxidants is superior to statins alone in decreasing the risk of cardiovascular disease in a subgroup of middle-aged individuals with both diabetes mellitus and the haptoglobin 2-2 genotype. Arterioscler Thromb Vasc Biol 28 (2008) e18-e20
6. Levy A.P., Gerstein H., Lotan R., Ratner R., McQueen M., Lonn E., et al. The effect of vitamin E supplementation on cardiovascular risk in diabetic individuals with different haptoglobin phenotypes. Diabetes Care 27 (2004) 2767