Flavonoids from Inula britannica L. inhibit injury-induced neointimal formation by suppressing oxidative-stress generation

Journal of Ethnopharmacology

Volumn 126, Issue 1, 2009, Pages 176-183

  Zhang, Hong Bing ^a,b   Wen, Jin Kun ^a   Wang, Yan Yan ^a   Zheng, Bin ^a   Han, Mei ^a  

^a HEBEI MEDICAL UNIVERSITY   (China)

^b HEBEI UNIVERSITY OF ECONOMICS AND BUSINESS   (China)

Author keywords

Antioxidants; Flavonoids; Inula britannica L.; Neointimal hyperplasia

Indexed keywords

ATORVASTATIN; FLAVONOID; INULA BRITTANICA EXTRACT; ISORHAMNETIN; LUTEOLIN; MALONALDEHYDE; OXYGEN; PLANT EXTRACT; PROTEIN P47; QUERCETIN; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTERY INJURY; ARTERY INTIMA; ARTERY INTIMA PROLIFERATION; ARTERY MEDIA; ARTICLE; CAROTID ARTERY; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG STRUCTURE; ENZYME ACTIVITY; FEEDING; IMMUNOHISTOCHEMISTRY; INULA; INULA BRITTANICA; MALE; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; RAT; TREATMENT OUTCOME; VASCULAR TISSUE; WESTERN BLOTTING;

ANIMALS; BALLOON DILATATION; CAROTID ARTERY INJURIES; DISEASE MODELS, ANIMAL; DRUGS, CHINESE HERBAL; FLAVONOIDS; HYPERPLASIA; INULA; MALE; MALONDIALDEHYDE; MICROFILAMENT PROTEINS; MOLECULAR STRUCTURE; MUSCLE PROTEINS; NADPH OXIDASE; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; SUPEROXIDE DISMUTASE; TUNICA INTIMA;

INULA BRITANNICA; RATTUS;

EID: 70349783670     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2009.05.045     Document Type: Article

References (34)

1. Chan E.C., Datla S.R., Dilley R., Hickey H., Drummond G.R., and Dusting G.J. Adventitial application of the NADPH oxidase inhibitor apocynin in vivo reduces neointima formation and endothelial dysfunction in rabbits. Cardiovascular Research 75 (2007) 710-718
2. Duarte J., Perez-Palencia R., Vargas F., Ocete M.A., Perez-Vizcaino F., Zarzuelo A., and Tamargo J. Antihypertensive effects of the flavonoid quercetin in spontaneously hypertensive rats. British Journal of Pharmacology 133 (2001) 117-124
3. Durand E., Al Haj Zen A., Addad F., Brasselet C., Caligiuri G., Vinchon F., Lemarchand P., Desnos M., Bruneval P., and Lafont A. Adenovirus-mediated gene transfer of superoxide dismutase and catalase decreases restenosis after balloon angioplasty. Journal of Vascular Research 42 (2005) 255-265
4. Geng H.M., Zhang D.Q., Zha J.P., and Qi J.L. Simultaneous HPLC determination of five flavonoids in Flos inulae. Chromatographia 66 (2007) 271-275
5. Grassi D., Aggio A., Onori L., Croce G., Tiberti S., Ferri C., Ferri L., and Desideri G. Tea, flavonoids, and nitric oxide-mediated vascular reactivity. Journal of Nutrition 138 (2008) 1554S-1560S
6. Griendling K.K., and Harrison D.G. Dual role of reactive oxygen species in vascular growth. Circulation Research 85 (1999) 562-563
7. Griendling K.K., Sorescu D., and Ushio-Fukai M. NAD(P)H oxidase: role in cardiovascular biology and disease. Circulation Research 86 (2000) 494-501
8. Griendling K.K., and FitzGerald G.A. Oxidative stress and cardiovascular injury. Part II. Animal and human studies. Circulation 108 (2003) 2034-2040
9. Guijarro M.V., Leal J.F., Blanco-Aparicio C., Alonso S., Fominaya J., Lleonart M., Castellvi J., Ramon y Cajal S., and Carnero A. MAP17 enhances the malignant behavior of tumor cells through ROS increase. Carcinogenesis 28 (2007) 2096-2104
10. Han M., Wen J.K., Zheng B., Liu Z., and Chen Y. Blockade of integrin beta3-FAK signaling pathway activated by osteopontin inhibits neointimal formation after balloon injury. Cardiovascular Pathology 16 (2007) 283-290
11. Heckenkamp J., Gawenda M., and Brunkwall J. Vascular restenosis. Basic science and clinical implications. Journal of Cardiovascular Surgery 43 (2002) 349-357
12. Hertog M.G., Feskens E.J., Hollman P.C., Katan M.B., and Kromhout D. Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study. Lancet 342 (1993) 1007-1011
13. Hollman P.C., and Katan M.B. Dietary flavonoids: intake, health effects and bioavailability. Food and Chemical Toxicology 37 (1999) 937-942
14. Hooper L., Kroon P.A., Rimm E.B., Cohn J.S., Harvey I., Le Cornu K.A., Ryder J.J., Hall W.L., and Cassidy A. Flavonoids, flavonoid-rich foods, and cardiovascular risk: a meta-analysis of randomized controlled trials. American Journal of Clinical Nutrition 88 (2008) 38-50
15. Huxley R.R., and Neil H.A. The relation between dietary flavonol intake and coronary heart disease mortality: a meta-analysis of prospective cohort studies. European Journal of Clinical Nutrition 57 (2003) 904-908
16. Jacobson G.M., Dourron H.M., Liu J., Carretero O.A., Reddy D.J., Andrzejewski T., and Pagano P.J. Novel NAD(P)H oxidase inhibitor suppresses angioplasty-induced superoxide and neointimal hyperplasia of rat carotid artery. Circulation Research 92 (2003) 637-643
17. Jiang F., Drummond G.R., and Dusting G.J. Suppression of oxidative stress in the endothelium and vascular wall. Endothelium 11 (2004) 79-88
18. Leite P.F., Danilovic A., Moriel P., Dantas K., Marklund S., Dantas A.P., and Laurindo F.R. Sustained decrease in superoxide dismutase activity underlies constrictive remodeling after balloon injury in rabbits. Arteriosclerosis, Thrombosis, and Vascular Biology 23 (2003) 2197-2202
19. Li J.M., and Shah A.M. Mechanism of endothelial cell NADPH oxidase activation by angiotensin. II. Role of the p47phox subunit. Journal of Biological Chemistry 278 (2003) 12094-12100
20. Liu B., Han M., and Wen J.K. Acetylbritannilactone inhibits neointimal hyperplasia after balloon injury of rat artery by suppressing nuclear factor-{kappa}B activation. The Journal of Pharmacology and Experimental Therapeutics 324 (2008) 292-298
21. Liu J., Ormsby A., Oja-Tebbe N., and Pagano P.J. Gene transfer of NAD(P)H oxidase inhibitor to the vascular adventitia attenuates medial smooth muscle hypertrophy. Circulation Research 95 (2004) 587-594
22. Liu Y.P., Wen J.K., Zheng B., Zhang D.Q., and Han M. Acetylbritannilactone suppresses lipopolysaccharide-induced vascular smooth muscle cell inflammatory response. European Journal of Pharmacology 577 (2007) 28-34
23. Middleton Jr. E., Kandaswami C., and Theoharides T.C. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacological Reviews 52 (2000) 673-751
24. Molina M.F., Sanchez-Reus I., Iglesias I., and Benedi J. Quercetin, a flavonoid antioxidant, prevents and protects against ethanol-induced oxidative stress in mouse liver. Biological & Pharmaceutical Bulletin 26 (2003) 1398-1402
25. Nakamura K., Yamagishi S., Matsui T., Yoshida T., Takenaka K., Jinnouchi Y., Yoshida Y., Ueda S., Adachi H., and Imaizumi T. Pigment epithelium-derived factor inhibits neointimal hyperplasia after vascular injury by blocking NADPH oxidase-mediated reactive oxygen species generation. American Journal of Pathology 170 (2007) 2159-2170
26. Rush J.W., Turk J.R., and Laughlin M.H. Exercise training regulates SOD-1 and oxidative stress in porcine aortic endothelium. American Journal of Physiology Heart and Circulatory Physiology 284 (2003) H1378-H1387
27. Sanchez M., Galisteo M., Vera R., Villar I.C., Zarzuelo A., Tamargo J., Perez-Vizcaino F., and Duarte J. Quercetin downregulates NADPH oxidase, increases eNOS activity and prevents endothelial dysfunction in spontaneously hypertensive rats. Journal of Hypertension 24 (2006) 75-84
28. Sanchez M., Lodi F., Vera R., Villar I.C., Cogolludo A., Jimenez R., Moreno L., Romero M., Tamargo J., Perez-Vizcaino F., and Duarte J. Quercetin and isorhamnetin prevent endothelial dysfunction, superoxide production, and overexpression of p47phox induced by angiotensin II in rat aorta. Journal of Nutrition 137 (2007) 910-915
29. Shi Y., Niculescu R., Wang D., Patel S., Davenpeck K.L., and Zalewski A. Increased NAD(P)H oxidase and reactive oxygen species in coronary arteries after balloon injury. Arteriosclerosis, Thrombosis, and Vascular Biology 21 (2001) 739-745
30. Souza H.P., Souza L.C., Anastacio V.M., Pereira A.C., Junqueira M.L., Krieger J.E., da Luz P.L., Augusto O., and Laurindo F.R. Vascular oxidant stress early after balloon injury: evidence for increased NAD(P)H oxidoreductase activity. Free Radical Biology and Medicine 28 (2000) 1232-1242
31. Srivastava S., Chandrasekar B., Bhatnagar A., and Prabhu S.D. Lipid peroxidation-derived aldehydes and oxidative stress in the failing heart: role of aldose reductase. American Journal of Physiology. Heart and Circulatory Physiology 283 (2002) H2612-H2619
32. Taniyama Y., and Griendling K.K. Reactive oxygen species in the vasculature: molecular and cellular mechanisms. Hypertension 42 (2003) 1075-1081
33. Touyz R.M., Yao G., and Schiffrin E.L. c-Src induces phosphorylation and translocation of p47phox: role in superoxide generation by angiotensin II in human vascular smooth muscle cells. Arteriosclerosis, Thrombosis, and Vascular Biology 23 (2003) 981-987
34. van Acker S.A., van den Berg D.J., Tromp M.N., Griffioen D.H., van Bennekom W.P., van der Vijgh W.J., and Bast A. Structural aspects of antioxidant activity of flavonoids. Free Radical Biology and Medicine 20 (1996) 331-342