HLA class I alleles tag HLA-DRB1*1501 haplotypes for differential risk in multiple sclerosis susceptibility

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 35, 2008, Pages 13069-13074

  Chao, Michael J ^a,b   Barnardo, Martin C N M ^c   Lincoln, Matthew R ^a,b   Ramagopalan, Sreeram V ^a,b   Herrera, Blanca M ^a,b   Dyment, David A ^a,b   Montpetit, Alexandre ^d   Sadovnick, A Dessa ^e   Knight, Julian C ^b   Ebers, George C ^a,b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c CHURCHILL HOSPITAL   (United Kingdom)

^d MCGILL UNIVERSITY   (Canada)

^e UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Class II; MHC; Transmission

Indexed keywords

HLA ANTIGEN CLASS 1; HLA DR ANTIGEN;

ALLELE; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE PREDISPOSITION; EPIGENETICS; GENE CONTROL; GENE FREQUENCY; GENE FUNCTION; GENE LOCUS; HAPLOTYPE; HUMAN; IMMUNE RESPONSE; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; RISK ASSESSMENT; STRUCTURE ANALYSIS;

ALLELES; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HISTOCOMPATIBILITY ANTIGENS CLASS I; HLA-A ANTIGENS; HLA-B ANTIGENS; HLA-DR ANTIGENS; HUMANS; MULTIPLE SCLEROSIS;

ANIMALIA;

EID: 51349145721     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0801042105     Document Type: Article

References (34)

1. Martin R, McFarland HF, McFarlin DE (1992) Immunological aspects of demyelinating diseases. Annu Rev Immunol 10:153-187.
2. Hafler DA (2004) Multiple sclerosis. J Clin Invest 113:788-794.
3. Zamvil SS, Steinman L (1990) The T lymphocyte in experimental allergic encephalomyelitis. Annu Rev Immunol 8:579-621.
4. Gregersen JW, et al. (2006) Functional epistasis on a common MHC haplotype associated with multiple sclerosis. Nature 443:574-577.
5. Ebers GC, et al. (1996) A full genome search in multiple sclerosis. Nat Genet 13:472-476.
6. Haines JL, et al. (1998) Linkage of the MHC to familial multiple sclerosis suggests genetic heterogeneity. Hum Mol Genet 7:1229-1234.
7. Dyment DA, Ebers GC, Sadovnick AD (2004) The genetics of MS. Lancet Neurol 3:104-110.
8. Dyment DA, et al. (2005) Complex interactions among MHC haplotypes in multiple sclerosis: Susceptibility and resistance. Hum Mol Genet 14:2019-2026.
9. Lincoln MR et al. (2005) A predominant role for the HLA class II region in the association of the MHC region with multiple sclerosis. Nat Genet 37:1108-1112.
10. Ebers GC (2008) Environmental factors and multiple sclerosis. Lancet Neurol 7:268-277.
11. Ebers GC, Sadovnick AD (1994) The role of genetic factors in multiple sclerosis susceptibility. J Neuroimmunol 54:1-17.
12. Hains JL, et al. (1996) A complete genomic screen for multiple sclerosis underscores a role for the major histocompatability complex. Nat Genet 13:469-471.
13. Sawcer S, et al. (1996) A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p21 and 17q22. Nat Genet 13:464-468.
14. Kuokkanen S, et al. (1997) Genomewide scan of multiple sclerosis in Finnish multiplex families. Am J Hum Genet 61:1379-1387.
15. Zhang Z, et al. (2005) Two genes encoding immune-regulatory molecules (LAG3 and IL7R) confer susceptibility to multiple sclerosis. Genes Immun 6:145-152.
16. Sawcer S, et al. (2002) A whole genome screen for linkage disequilibrium in multiple sclerosis confirms disease associations with regions previously linked to susceptibility. Brain 125:1337-1347.
17. Oturai A, et al. (1999) Linkage and association analysis of susceptibility regions on chromosome 5 and 6 in 106 Scandinavian sibling pair families with multiple sclerosis. Ann Neruol 46:612-616.
18. Gregory SG, et al. (2007) Interleukin 7 receptor α chain (IL7R) shows allelic and functional association with multiple sclerosis. Nat Genet 39:1083-1091.
19. Lundmark F, et al. (2007) Variation in interleukin 7 receptor α chain (IL7R) influences risk of multiple sclerosis. Nat Genet 39:1108-1113.
20. Risch N, Merikangas K (1996) The future of genetic studies of complex human disease. Science 273:1516-1517.
21. Peltonen L (2007) Old suspects found guilty - the first genome profile of multiple sclerosis. N Engl J Med 357:927-929.
22. Fogdell-Hahn A, Ligers A, Gronning M, Hillert J, Olerup O (2000) Multiple sclerosis: A modifying influence of HLA class I genes in an HLA class II associated autoimmune disease. Tissue Antigens 55:140-148.
23. Harbo HF, et al. (2004) Genes in the HLA class I region may contribute to the HLA class II-associated genetic susceptibility to multiple sclerosis. Tissue Antigens 63:237-247.
24. Yeo TW, et al. (2007) A second major histocompatibility complex susceptibility locus for multiple sclerosis Ann Neurol 61:228-236.
25. Chao MJ, et al. (2007) Transmission of class I/II multi-locus MHC haplotypes and multiple sclerosis susceptibility: Accounting for linkage disequilibrium. Hum Mol Genet 16:1951-1958.
26. Ligers A, et al. (2001) Evidence of linkage with HLA-DR in DRB1*15-negative families with multiple sclerosis. Am J Hum Genet 69:900-903.
27. Ghabanbasani MZ, et al. (1995) Importance of HLA-DRB1 and DQA1 genes and of the amino acid polymorphisms in the functional domain of DR beta 1 chain in multiple sclerosis. J Neuroimmunol 59:77-82.
28. Haegert DG, Swift FV, Benedikz J (1996) Evidence for a complex role of HLA class II genotypes in susceptibility to multiple sclerosis in Iceland. Neurology 46:1107-1111.
29. Spurkland A, et al. (1997) The HLA-DQ (alpha 1*0102, beta 1*0602) heterodimer may confer susceptibility to multiple sclerosis in the absence of HLA-DR (alpha 1*01, beta 1*1501) heterodimer. Tissue Antigens 50:15-22.
30. Seltman H, Roeder K, Devlin B (2001) Transmission/disequilibrium test meets measure haplotype analysis: Family-based association analysis guided by evolution of haplotypes. Am J Hum Genet 68:1250-1263.
31. Sadovnick AD, Risch NJ, Ebers GC, The Canadian Collaborative Study Group (1998) Canadian collaborative project on genetic susceptibility to MS, phase 2: Rationale and method. Can J Neurol Sci 25:216-221.
32. Bunce M, et al. (1995) Phototyping: Comprehensive DNA typing for HLA-A, B, C, DRB1, DRB3, DRB4, DRB5 and DQB1 by PCR with 144 primer mixes utilizing sequence-specific primers (PCR-SSP). Tissue Antigens 46:355-367.
33. O'Connel JR, Weeks DE (1998) PedCheck: A program for identifying genotype incompatibilities in linkage analysis. Am J Hum Genet 63:259-266.
34. Dudbridge F (2003) Pedigree disequilibrium tests for multilocus haplotypes. Genet Epidemiol 25:115-221.