Chapter 20 Gene Therapy Perspectives for Nerve Repair

International Review of Neurobiology

Volumn 87, Issue C, 2009, Pages 381-392

  Zacchigna, Serena ^a   Giacca, Mauro ^a  

^a INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; BOTULINUM TOXIN; BRAIN DERIVED NEUROTROPHIC FACTOR; CARDIOTROPHIN 1; CILIARY NEUROTROPHIC FACTOR; FIBROBLAST GROWTH FACTOR 2; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; LENTIVIRUS VECTOR; NERVE GROWTH FACTOR; NEUROTROPHIC FACTOR; SCATTER FACTOR; SOMATOMEDIN C; TRANSFORMING GROWTH FACTOR BETA; VASCULOTROPIN; VIRUS VECTOR; TISSUE SCAFFOLD;

AMYOTROPHIC LATERAL SCLEROSIS; CELL SURVIVAL; CELL VIABILITY; CLINICAL TRIAL; DIABETES MELLITUS; DIABETIC NEUROPATHY; DNA SEQUENCE; DRUG EFFICACY; GENE EXPRESSION; GENE OVEREXPRESSION; GENE THERAPY; GENE TRANSFER; HUMAN; IMMUNOREGULATION; MOTONEURON; MYELINATION; NERVE FIBER GROWTH; NERVE GRAFT; NERVE INJURY; NERVE REGENERATION; NEUROPATHY; NEUROPROTECTION; NONHUMAN; PERIPHERAL NERVOUS SYSTEM; PLASMID; PRIORITY JOURNAL; REVIEW; SCHWANN CELL; SIGNAL TRANSDUCTION; ANIMAL; BLOOD VESSEL; GENE VECTOR; GENETICS; HERPES SIMPLEX VIRUS; LENTIVIRINAE; METHODOLOGY; MUSCLE; PERIPHERAL NERVE; PHYSIOLOGY; PROMOTER REGION;

ANIMALS; BLOOD VESSELS; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HUMANS; LENTIVIRUS; MUSCLES; NERVE REGENERATION; PERIPHERAL NERVES; PROMOTER REGIONS, GENETIC; SCHWANN CELLS; SIMPLEXVIRUS; TISSUE SCAFFOLDS;

EID: 70349782901     PISSN: 00747742     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0074-7742(09)87020-7     Document Type: Review

References (52)

1. Abrams M., and Widenfalk J. Emerging strategies to promote improved functional outcome after peripheral nerve injury. Restor. Neurol. Neurosci. 23 5-6 (2005) 367-382
2. Anesti A.M., Peeters P.J., Royaux I., and Coffin R.S. Efficient delivery of RNA interference to peripheral neurons in vivo using herpes simplex virus. Nucleic Acids Res. 36 14 (2008) e86
3. Araki K., Shiotani A., Watabe K., Saito K., Moro K., and Ogawa K. Adenoviral GDNF gene transfer enhances neurofunctional recovery after recurrent laryngeal nerve injury. Gene Ther. 13 4 (2006) 296-303
4. Aspalter M., Vyas A., Feiner J., Griffin J., Brushart T., and Redett R. Modification of Schwann cell gene expression by electroporation in vivo. J. Neurosci. Methods 176 2 (2009) 96-103
5. Battiston B., Tos P., Conforti L.G., and Geuna S. Alternative techniques for peripheral nerve repair: Conduits and end-to-side neurorrhaphy. Acta Neurochir. Suppl. 100 (2007) 43-50
6. Buning H., Nicklin S.A., Perabo L., Hallek M., and Baker A.H. AAV-based gene transfer. Curr. Opin. Mol. Ther. 5 4 (2003) 367-375
7. Carmeliet P., and Tessier-Lavigne M. Common mechanisms of nerve and blood vessel wiring. Nature 436 7048 (2005) 193-200
8. Chattopadhyay M., Goss J., Lacomis D., Goins W.C., Glorioso J.C., Mata M., and Fink D.J. Protective effect of HSV-mediated gene transfer of nerve growth factor in pyridoxine neuropathy demonstrates functional activity of trkA receptors in large sensory neurons of adult animals. Eur. J. Neurosci. 17 4 (2003) 732-740
9. Chattopadhyay M., Goss J., Wolfe D., Goins W.C., Huang S., Glorioso J.C., Mata M., and Fink D.J. Protective effect of herpes simplex virus-mediated neurotrophin gene transfer in cisplatin neuropathy. Brain 127 Pt. 4 (2004) 929-939
10. Chattopadhyay M., Wolfe D., Mata M., Huang S., Glorioso J.C., and Fink D.J. Long-term neuroprotection achieved with latency-associated promoter-driven herpes simplex virus gene transfer to the peripheral nervous system. Mol. Ther. 12 2 (2005) 307-313
11. Eichmann A., Le Noble F., Autiero M., and Carmeliet P. Guidance of vascular and neural network formation. Curr. Opin. Neurobiol. 15 1 (2005) 108-115
12. Federici T., Kutner R., Zhang X.Y., Kuroda H., Tordo N., Boulis N.M., and Reiser J. Comparative analysis of HIV-1-based lentiviral vectors bearing lyssavirus glycoproteins for neuronal gene transfer. Genet. Vaccines Ther. 7 1 (2009) 1
13. Federici T., Liu J.K., Teng Q., Yang J., and Boulis N.M. A means for targeting therapeutics to peripheral nervous system neurons with axonal damage. Neurosurgery 60 5 (2007) 911-918 discussion 911-918
14. Feng Z., and Ko C.P. Schwann cells promote synaptogenesis at the neuromuscular junction via transforming growth factor-beta1. J. Neurosci. 28 39 (2008) 9599-9609
15. Feng Z., and Ko C.P. The role of glial cells in the formation and maintenance of the neuromuscular junction. Ann. N.Y. Acad. Sci. 1132 (2008) 19-28
16. Fu C., Hong G., and Wang F. Favorable effect of local VEGF gene injection on axonal regeneration in the rat sciatic nerve. J. Huazhong Univ. Sci. Technol. Med. Sci. 27 2 (2007) 186-189
17. Goins W.F., Sternberg L.R., Croen K.D., Krause P.R., Hendricks R.L., Fink D.J., Straus S.E., Levine M., and Glorioso J.C. A novel latency-active promoter is contained within the herpes simplex virus type 1 UL flanking repeats. J. Virol. 68 4 (1994) 2239-2252
18. Golden K.L., Pearse D.D., Blits B., Garg M.S., Oudega M., Wood P.M., and Bunge M.B. Transduced Schwann cells promote axon growth and myelination after spinal cord injury. Exp. Neurol. 207 2 (2007) 203-217
19. Goss J.R., Goins W.F., Lacomis D., Mata M., Glorioso J.C., and Fink D.J. Herpes simplex-mediated gene transfer of nerve growth factor protects against peripheral neuropathy in streptozotocin-induced diabetes in the mouse. Diabetes 51 7 (2002) 2227-2232
20. Guo J.S., Zeng Y.S., Li H.B., Huang W.L., Liu R.Y., Li X.B., Ding Y., Wu L.Z., and Cai D.Z. Cotransplant of neural stem cells and NT-3 gene modified Schwann cells promote the recovery of transected spinal cord injury. Spinal Cord 45 1 (2007) 15-24
21. Haastert K., and Grothe C. Gene therapy in peripheral nerve reconstruction approaches. Curr. Gene Ther. 7 3 (2007) 221-228
22. Haastert K., Lipokatic E., Fischer M., Timmer M., and Grothe C. Differentially promoted peripheral nerve regeneration by grafted Schwann cells over-expressing different FGF-2 isoforms. Neurobiol. Dis. 21 1 (2006) 138-153
23. Haastert K., Mauritz C., Chaturvedi S., and Grothe C. Human and rat adult Schwann cell cultures: Fast and efficient enrichment and highly effective non-viral transfection protocol. Nat. Protoc. 2 1 (2007) 99-104
24. Haile Y., Haastert K., Cesnulevicius K., Stummeyer K., Timmer M., Berski S., Drager G., Gerardy-Schahn R., and Grothe C. Culturing of glial and neuronal cells on polysialic acid. Biomaterials 28 6 (2007) 1163-1173
25. Honma Y., Araki T., Gianino S., Bruce A., Heuckeroth R., Johnson E., and Milbrandt J. Artemin is a vascular-derived neurotropic factor for developing sympathetic neurons. Neuron 35 2 (2002) 267-282
26. Kaspar B.K., Llado J., Sherkat N., Rothstein J.D., and Gage F.H. Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model. Science 301 5634 (2003) 839-842
27. Kirchmair R., Tietz A.B., Panagiotou E., Walter D.H., Silver M., Yoon Y.S., Schratzberger P., Weber A., Kusano K., Weinberg D.H., Ropper A.H., Isner J.M., et al. Therapeutic angiogenesis inhibits or rescues chemotherapy-induced peripheral neuropathy: Taxol- and thalidomide-induced injury of vasa nervorum is ameliorated by VEGF. Mol. Ther. 15 1 (2007) 69-75
28. Kuruvilla R., Zweifel L.S., Glebova N.O., Lonze B.E., Valdez G., Ye H., and Ginty D.D. A neurotrophin signaling cascade coordinates sympathetic neuron development through differential control of TrkA trafficking and retrograde signaling. Cell 118 2 (2004) 243-255
29. Li Q., Ping P., Jiang H., and Liu K. Nerve conduit filled with GDNF gene-modified Schwann cells enhances regeneration of the peripheral nerve. Microsurgery 26 2 (2006) 116-121
30. Li Z., Peng J., Wang G., Yang Q., Yu H., Guo Q., Wang A., Zhao B., and Lu S. Effects of local release of hepatocyte growth factor on peripheral nerve regeneration in acellular nerve grafts. Exp. Neurol. 214 1 (2008) 47-54
31. Liu B., Paton J.F., and Kasparov S. Viral vectors based on bidirectional cell-specific mammalian promoters and transcriptional amplification strategy for use in vitro and in vivo. BMC Biotechnol. 8 (2008)
32. Liu B.H., Wang X., Ma Y.X., and Wang S. CMV enhancer/human PDGF-beta promoter for neuron-specific transgene expression. Gene Ther. 11 1 (2004) 52-60
33. Makwana M., and Raivich G. Molecular mechanisms in successful peripheral regeneration. FEBS J. 272 11 (2005) 2628-2638
34. Millecamps S., Mallet J., and Barkats M. Adenoviral retrograde gene transfer in motoneurons is greatly enhanced by prior intramuscular inoculation with botulinum toxin. Hum. Gene Ther. 13 2 (2002) 225-232
35. Mukouyama Y.S., Shin D., Britsch S., Taniguchi M., and Anderson D.J. Sensory nerves determine the pattern of arterial differentiation and blood vessel branching in the skin. Cell 109 6 (2002) 693-705
36. Murakami T., Arai M., Sunada Y., and Nakamura A. VEGF 164 gene transfer by electroporation improves diabetic sensory neuropathy in mice. J. Gene Med. 8 6 (2006) 773-781
37. Nagahara A.H., Bernot T., Moseanko R., Brignolo L., Blesch A., Conner J.M., Ramirez A., Gasmi M., and Tuszynski M.H. Long-term reversal of cholinergic neuronal decline in aged non-human primates by lentiviral NGF gene delivery. Exp. Neurol. 215 1 (2009) 153-159
38. Natsume A., Wolfe D., Hu J., Huang S., Puskovic V., Glorioso J.C., Fink D.J., and Mata M. Enhanced functional recovery after proximal nerve root injury by vector-mediated gene transfer. Exp. Neurol. 184 2 (2003) 878-886
39. Ng B.K., Chen L., Mandemakers W., Cosgaya J.M., and Chan J.R. Anterograde transport and secretion of brain-derived neurotrophic factor along sensory axons promote Schwann cell myelination. J. Neurosci. 27 28 (2007) 7597-7603
40. Palmer J.A., Branston R.H., Lilley C.E., Robinson M.J., Groutsi F., Smith J., Latchman D.S., and Coffin R.S. Development and optimization of herpes simplex virus vectors for multiple long-term gene delivery to the peripheral nervous system. J. Virol. 74 12 (2000) 5604-5618
41. Perez M.C., Hunt S.P., Coffin R.S., and Palmer J.A. Comparative analysis of genomic HSV vectors for gene delivery to motor neurons following peripheral inoculation in vivo. Gene Ther. 11 13 (2004) 1023-1032
42. Rovak J.M., Mungara A.K., Aydin M.A., and Cederna P.S. Effects of vascular endothelial growth factor on nerve regeneration in acellular nerve grafts. J. Reconstr. Microsurg. 20 1 (2004) 53-58
43. Sakamoto T., Kawazoe Y., Shen J.S., Takeda Y., Arakawa Y., Ogawa J., Oyanagi K., Ohashi T., Watanabe K., Inoue K., Eto Y., and Watabe K. Adenoviral gene transfer of GDNF, BDNF and TGF beta 2, but not CNTF, cardiotrophin-1 or IGF1, protects injured adult motoneurons after facial nerve avulsion. J. Neurosci. Res. 72 1 (2003) 54-64
44. Schmidt C.E., and Leach J.B. Neural tissue engineering: Strategies for repair and regeneration. Ann. Rev. Biomed. Eng. 5 (2003) 293-347
45. Schratzberger P., Schratzberger G., Silver M., Curry C., Kearney M., Magner M., Alroy J., Adelman L.S., Weinberg D.H., Ropper A.H., and Isner J.M. Favorable effect of VEGF gene transfer on ischemic peripheral neuropathy. Nat. Med. 6 4 (2000) 405-413
46. Simovic D., Isner J.M., Ropper A.H., Pieczek A., and Weinberg D.H. Improvement in chronic ischemic neuropathy after intramuscular phVEGF165 gene transfer in patients with critical limb ischemia. Arch. Neurol. 58 5 (2001) 761-768
47. Streppel M., Heiser T., and Stennert E. Historical development of facial nerve surgery with special reference to hypoglossal-facial nerve anastomosis. HNO 48 11 (2000) 801-808
48. Watanabe T.S., Ohtori S., Koda M., Aoki Y., Doya H., Shirasawa H., Yamazaki M., Moriya H., Takahashi K., and Yamashita T. Adenoviral gene transfer in the peripheral nervous system. J. Orthop. Sci. 11 1 (2006) 64-69
49. Wong L.F., Yip P.K., Battaglia A., Grist J., Corcoran J., Maden M., Azzouz M., Kingsman S.M., Kingsman A.J., Mazarakis N.D., and McMahon S.B. Retinoic acid receptor beta2 promotes functional regeneration of sensory axons in the spinal cord. Nat. Neurosci. 9 2 (2006) 243-250
50. Xu J., Ma C., Bass C., and Terwilliger E.F. A combination of mutations enhances the neurotropism of AAV-2. Virology 341 2 (2005) 203-214
51. Zacchigna S., Lambrechts D., and Carmeliet P. Neurovascular signalling defects in neurodegeneration. Nat. Rev. Neurosci. 9 3 (2008) 169-181
52. Zacchigna S., Ruiz de Almodovar C., and Carmeliet P. Similarities between angiogenesis and neural development: What small animal models can tell us. Curr. Top. Dev. Biol. 80 (2008) 1-55