Heterocyclic replacement of the central phenyl core of diamine-based histamine H3 receptor antagonists

European Journal of Medicinal Chemistry

Volumn 44, Issue 11, 2009, Pages 4413-4425

  Swanson, Devin M ^a   Shah, Chandra R ^a   Lord, Brian ^a   Morton, Kirsten ^a   Dvorak, Lisa K ^a   Mazur, Curt ^a   Apodaca, Richard ^a   Xiao, Wei ^a   Boggs, Jamin D ^a   Feinstein, Mark ^a   Wilson, Sandy J ^a   Barbier, Ann J ^a   Bonaventure, Pascal ^a   Lovenberg, Timothy W ^a   Carruthers, Nicholas I ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

H3 receptor antagonist; Heterocyclic replacement; Histamine

Indexed keywords

(2 METHOXY ETHYL) [3 (3 PIPERIDIN 1 YL PROPOXY)ISOXAZOL 5 YLMETHYL]AMINE; (4 ISOPROPYL PIPERAZIN 1 YL) (4 PIPERIDIN 1 YLMETHYLPHENYL)METHANONE; (4 ISOPROPYL PIPERAZIN 1 YL) (5 MORPHOLIN 4 YLMETHYLPYRAZIN 2 YL)METHANONE; (4 ISOPROPYL PIPERAZIN 1 YL) (5 PIPERIDIN 1 YLMETHYLPYRAZIN 2 YL)METHANONE; (4 ISOPROPYL PIPERAZIN 1 YL) (6 MORPHOLIN 4 YLMETHYLPYRIDIN 3 YL)METHANONE; (4 ISOPROPYL PIPERAZIN 1 YL) (6 PIPERIDIN 1 YLMETHYL PYRIDIN 3 YL)METHANONE; (4 ISOPROPYL PIPERAZIN 1 YL) (6 PIPERIDIN 1 YLMETHYLPYRIDIN 3 YL) METHANETHIONE; (4 ISOPROPYL PIPERAZIN 1 YL) (6 PIPERIDIN 1 YLMETHYLPYRIDIN 3 YL)METHANONE; (5 HYDROXY PYRIDIN 2 YL)MORPHOLIN 4 YL METHANONE; (5 HYDROXY PYRIDIN 2 YL)PIPERIDIN 1 YL METHANONE; (6 BROMO PYRIDIN 3 YL)PIPERIDIN 1 YL METHANONE; 2 BROMO 5 PIPERIDIN 1 YLMETHYL PYRIDINE; 2 PIPERDIN 1 YLMETHYL 5 (3 PIPERDIN 1 YL PROPOXY)PYRIDINE; 3 (3 PIPERIDIN 1 YL PROPOXY)ISOXAZOLE 5 CARBOXYLIC ACID METHYL ESTER; 4 [3 (3 PIPERIDIN 1 YL PROPOXY)ISOXAZOL 5 YLMETHYL]MORPHOLINE; 4 [3 (3 PIPERIDIN 1 YL PROPOXY)ISOXAZOL 5 YLMETHYL]PIPERIDINE; 4 [5 (3 PIPERIDIN 1 YL PROPOXY)PYRIDIN 2 YLMETHYL]MORPHOLINE; 5 FORMYL PYRAZINE 2 CARBOXYLIC ACID METHYL ESTER; 5 MORPHOLIN 4 YLMETHYL PYRAZINE 2 CARBOXYLIC ACID METHYL ESTER; 5 MORPHOLIN 4 YLMETHYL PYRIDINE 2 CARBOXYLIC ACID METHYL ESTER; 5 PIPERIDIN 1 YLMETHYL 2 (3 PIPERIDIN 1 YL PROPOXY)PYRIDINE; 5 PIPERIDIN 1 YLMETHYL PYRAZINE 2 CARBOXYLIC ACID METHYL ESTER; 6 (4 ISOPROPYL PIPERAZINE 1 CARBONYL)NICOTINIC ACID METHYL ESTER; 6 FORMYL NICOTINIC ACID METHYL ESTER; 6 MORPHOLIN 4 YLMETHYL PYRIDIN 3 OL; 6 PIPERIDIN 1 YLMETHYL NICOTINIC ACID METHYL ESTER; 6 PIPERIDIN 1 YLMETHYL PYRIDIN 3 OL; [3 (3 PIPERIDIN 1 YL PROPOXY)ISOXAZOL 5 YL]METHANOL; HISTAMINE H3 RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MALE; NONHUMAN; RAT;

ANIMALS; BLOOD-BRAIN BARRIER; CELL LINE; DIAMINES; HISTAMINE H3 ANTAGONISTS; HUMANS; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, HISTAMINE H3;

EID: 70349778603     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.06.007     Document Type: Article

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