Synthesis of some novel pyrazolo[3,4-b]pyridine and pyrazolo[3,4-d]pyrimidine derivatives bearing 5,6-diphenyl-1,2,4-triazine moiety as potential antimicrobial agents

European Journal of Medicinal Chemistry

Volumn 44, Issue 11, 2009, Pages 4385-4392

  El Sayed Ali, Tarik ^a  

^a Ain Shams University   (Egypt)

Author keywords

1,2,4 Triazine; Antimicrobial activity; Pyrazolo 3,4 b pyridines; Pyrazolo 3,4 d pyrimidines

Indexed keywords

1 (5,6 DIPHENYL 1,2,4 TRIAZIN 3 YL) 3 HYDRAZINO 6 METHYL 1,5 DIHYDRO 4H PYRAZOLO[3,4 D]PYRIMIDIN 4 ONE; 1 (5,6 DIPHENYL 1,2,4 TRIAZIN 3 YL) 6 METHYL 3 (METHYLTHIO) 1,5 DIHYDRO 4H PYRAZOLO[3,4 D]PYRIMIDIN 4 ONE; 1 (5,6 DIPHENYL 1,2,4 TRIAZIN 3 YL) 7 PHENYLPYRAZOLO[5,4,3 KL]PYRIMIDO[4,3 D]PYRIMIDINE 4(2H) THIONE; 2 AMINO 7 (5,6 DIPHENYL 1,2,4 TRIAZIN 3 YL) 4 METHYL 9 (METHYLTHIO) 5PHENYL 7H PYRAZOLO[3,4H][1,6]NAPHTHYRIDINE 3 CARBONITRILE; 2,13 DIAMINO 5 (5,6 DIPHENYL 1,2,4 TRAZIN 3 YL) 7 OXO 6,14 DIHYDROPYRAZOLO[1,5 A]QUINAZOLINO[3',2' 5,1](3 PYRZOLINO)[3,4 D]PYRIMIDINE 3 CARBONITRILE; 3,4 DIAMINO 2 (5,6 DIPHENYL 1,2,4 TRIAZIN 3 YL) 2,7 DIHYDRO 6H PYRAZOLO[3,4 D]PYRIMIDINE 6 THIONE; 4 AMINO 1 (5,6 DIPHENYL 1,2,4 TRIAZIN 3 YL) 6 METHYL 3 (METHYLTHIO) 1H PYRAZOLO[3,4 B]PYRIDINE 5 CARBONITRILE; 4,7 DIAMINO 1 (5,6 DIPHENYL 1,2,4 TRIAZIN 3 YL) 3 (METHYLTHIO) 1H DIPYRAZOLO[1,5 A:30,40 D]PYRIMIDINE 8 CARBONITRILE; 5 (5,6 DIPHENYL 1,2,4 TRIAZIN 3 YL) 7 METHYL 3 PHENYL 5H [1,2,4]TRIAZOLO[40,30:1,5]PYRAZOLO[3,4 D]PYRIMIDIN 9 (8H)-ONE; 5 ACETYL 4 AMINO 1 (5,6 DIPHENYL 1,2,4 TRIAZIN 3 YL) 6 PHENYL 3 (METHYLTHIO) 1H PYRAZOLO[3,4 B]PYRIDINE; 5 AMINO 1 (5,6 DIPHENYL 1,2,4 TRIAZIN 3 YL) 3 (METHYLTHIO) 1H PYRAZOLE 4 CARBONITRILE; 6 (5,6 DIPHENYL 1,2,4 TRIAZIN 3 YL) 3,8 DIMETHYLPYRIMIDO[40,50:3,4]PYRAZOLO[5,1 C][1,2,4]TRIAZINE 4,10 (6H,9H) DIONE; 6 ACETYL 3,7 DIPHENYL 1 (5,6 DIPHENYL 1,2,4 TRIAZIN 3 YL) 4 METHYLPYRAZOLO[5,4,3 KL]PYRIDO[4,3 D]PYRIMIDINE; 7 (5,6 DIPHENYL 1,2,4 TRIAZIN 3 YL) 5 METHYL 9 (METHYLTHIO) 3,7 DIHYDRO 4H PYRAZOLO[40,30:5,6]PYRIDO[4,3D]PYRIMIDIN 4 ONE; [[[4 CYANO 1 (5,6 DIPHENYL 1,2,4 TRIAZIN 3 YL) 3 (METHYLTHIO) 1H PYRAZOL 5 YL]AMINO](METHYLTHIO)METHYLENE]MALONONITRILE; ANTIFUNGAL AGENT; ANTIINFECTIVE AGENT; BLEOMYCIN; GALLIC ACID; KETOCONAZOLE; PYRAZOLO[3,4 B]PYRIDINE DERIVATIVE; PYRAZOLO[3,4 D]PYRIMIDINE DERIVATIVE; TETRACYCLINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; CYCLIZATION; CYTOTOXICITY; DRUG DETERMINATION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-INFECTIVE AGENTS; ARTEMIA; BIOLOGICAL ASSAY; ESCHERICHIA COLI; FUNGI; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; PYRAZOLES; PYRIDINES; PYRIMIDINES; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS; TRIAZINES;

EID: 70349774358     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.05.031     Document Type: Article

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