Ca2+ entry via α1G and TRPV4 channels differentially regulates surface expression of P-selectin and barrier integrity in pulmonary capillary endothelium

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 297, Issue 4, 2009, Pages

  Wu, Songwei ^a   Jian, Ming Yuan ^a   Xu, Yan Chun ^a   Zhou, Chun ^a   Al Mehdi, Abu Bakr ^a   Liedtke, Wolfgang ^b   Shin, Hee Sup ^c   Townsley, Mary I ^a  

^a UNIVERSITY OF SOUTH ALABAMA COLLEGE OF MEDICINE   (United States)

^b DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Korea Institute of Science and Technology   (South Korea)

Author keywords

T type calcium channel; Transient receptor potential vanilloid 4; Vascular permeability

Indexed keywords

4ALPHA PHORBOL DIDECANOATE; CALCIUM CHANNEL T TYPE; CALCIUM CHANNEL T TYPE ALPHA 1 G; CALCIUM ION; MIBEFRADIL; PADGEM PROTEIN; POTASSIUM ION; RUTHENIUM RED; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 4; CACNA1G PROTEIN, MOUSE; CALCIUM; CARCINOGEN; PHORBOL DIDECANOATE; PHORBOL ESTER; PHORBOL-12,13-DIDECANOATE; TRPV4 PROTEIN, MOUSE; VANILLOID RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL PERMEABILITY; CALCIUM TRANSPORT; CAPILLARY ENDOTHELIUM; CELL MEMBRANE DEPOLARIZATION; CONTROLLED STUDY; FEMALE; FLUORESCENCE MICROSCOPY; IMMUNOHISTOCHEMISTRY; ISOLATED LUNG; KNOCKOUT MOUSE; LUNG ALVEOLUS; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; ANIMAL; CALCIUM SIGNALING; CYTOLOGY; DRUG EFFECT; ENZYME IMMUNOASSAY; METABOLISM; MOUSE MUTANT; PULMONARY ARTERY; VASCULAR ENDOTHELIUM;

ANIMALS; CALCIUM; CALCIUM CHANNELS, T-TYPE; CALCIUM SIGNALING; CARCINOGENS; ENDOTHELIUM, VASCULAR; IMMUNOENZYME TECHNIQUES; MICE; MICE, KNOCKOUT; P-SELECTIN; PHORBOL ESTERS; PULMONARY ARTERY; TRPV CATION CHANNELS;

EID: 70349773183     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00015.2009     Document Type: Article

References (35)

1. Aird WC. Phenotypic heterogeneity of the endothelium. I. Structure, function, and mechanisms. Circ Res 100: 158-173, 2007. (Pubitemid 46208717)
2. Aird WC. Phenotypic heterogeneity of the endothelium. II. Representative vascular beds. Circ Res 100: 174-190, 2007. (Pubitemid 46208718)
3. Alvarez DF, King JA, Townsley MI. Resistance to store depletion-induced endothelial injury in rat lung after chronic heart failure. Am J Respir Crit Care Med 172: 1153-1160, 2005.
4. Alvarez DF, King JA, Weber D, Addison E, Liedtke W, Townsley MI. Transient receptor potential vanilloid 4-mediated disruption of the alveolar septal barrier: a novel mechanism of acute lung injury. Circ Res 99: 988-995, 2006. (Pubitemid 44657802)
5. 2+ sensors promotes fast and efficient transmitter release at a cortical GABAergic synapse. Neuron 57: 536-545, 2008.
6. 2+ entry. Am J Physiol Lung Cell Mol Physiol 276: L41-L50, 1999.
7. Fakler B, Adelman JP. Control of KCa channels by calcium nano/microdomains. Neuron 59: 873-881, 2008.
8. Hamanaka K, Jian MY, Weber DS, Alvarez DF, Townsley MI, Al-Mehdi AB, King JA, Liedtke W, Parker JC. TRPV4 initiates the acute calcium-dependent permeability increase during ventilator-induced lung injury in isolated mouse lungs. Am J Physiol Lung Cell Mol Physiol 293: L923-L932, 2007. (Pubitemid 47572240)
9. Ichimura H, Parthasarathi K, Quadri S, Issekutz AC, Bhattacharya J. Mechano-oxidative coupling by mitochondria induces proinflammatory responses in lung venular capillaries. J Clin Invest 111: 691-699, 2003. (Pubitemid 36278587)
10. Jian MY, King JA, Al-Mehdi AB, Liedtke W, Townsley MI. High vascular pressure-induced lung injury requires P450 epoxygenase-dependent activation of TRPV4. Am J Respir Cell Mol Biol 38: 386-392, 2008. (Pubitemid 351758684)
11. Khimenko PL, Moore TM, Wilson PS, Taylor AE. Role of calmodulin and myosin light-chain kinase in lung ischemia-reperfusion injury. Am J Physiol Lung Cell Mol Physiol 271: L121-L125, 1996. (Pubitemid 27372315)
12. 2+ channels. Neuron 31: 35-45, 2001.
13. King J, Hamil T, Creighton J, Wu S, Bhat P, McDonald F, Stevens T. Structural and functional characteristics of lung macro- and microvascular endothelial cell phenotypes. Microvasc Res 67: 139-151, 2004. (Pubitemid 38327000)
14. Liedtke W. Role of TRPV ion channels in sensory transduction of osmotic stimuli in mammals. Exp Physiol 92: 507-512, 2007. (Pubitemid 46608415)
15. -/- mice. Proc Natl Acad Sci USA 100: 13698-13703, 2003.
16. Liedtke W, Kim C. Functionality of the TRPV subfamily of TRP ion channels: add mechano-TRP and osmo-TRP to the lexicon! Cell Mol Life Sci 62: 2985-3001, 2005. (Pubitemid 43004750)
17. Lowe K, Alvarez D, King J, Stevens T. Phenotypic heterogeneity in lung capillary and extra-alveolar endothelial cells. Increased extra-alveolar endothelial permeability is sufficient to decrease compliance. J Surg Res 143: 70-77, 2007. (Pubitemid 47562440)
18. Moore TM, Khimenko P, Adkins WK, Miyasaka M, Taylor AE. Adhesion molecules contribute to ischemia and reperfusion-induced injury in the isolated rat lung. J Appl Physiol 78: 2245-2252, 1995.
19. Naka Y, Toda K, Kayano K, Oz MC, Pinsky DJ. Failure to express the P-selectin gene or P-selectin blockade confers early pulmonary protection after lung ischemia or transplantation. Proc Natl Acad Sci USA 94: 757-761, 1997. (Pubitemid 27053707)
20. Nilius B, Droogmans G. Ion channels and their functional role in vascular endothelium. Physiol Rev 81: 1415-1459, 2001. (Pubitemid 32947776)
21. O'Neil RG, Heller S. The mechanosensitive nature of TRPV channels. Pflügers Arch 451: 193-203, 2005.
22. Parker JC, Townsley MI. Evaluation of lung injury in rats and mice. Am J Physiol Lung Cell Mol Physiol 286: L231-L246, 2004.
23. Plant TD, Strotmann R. TRPV4. Handb Exp Pharmacol 179: 189-205, 2007.
24. Rich TC, Fagan KA, Tse TE, Schaack J, Cooper DM, Karpen JW. A uniform extracellular stimulus triggers distinct cAMP signals in different compartments of a simple cell. Proc Natl Acad Sci USA 98: 13049-13054, 2001. (Pubitemid 33051315)
25. 2+ signals and gap junction function are regulated by caveolin in endothelial cells. Circulation 117: 1065-1074, 2008.
26. Song C, Al-Mehdi AB, Fisher AB. An immediate endothelial cell signaling response to lung ischemia. Am J Physiol Lung Cell Mol Physiol 281: L993-L1000, 2001. (Pubitemid 32948183)
27. Taylor CW. Controlling calcium entry. Cell 111: 767-769, 2002.
28. 2+ channels and pulmonary endothelial permeability: insights from study of intact lung and chronic pulmonary hypertension. Microcirculation 13: 725-739, 2006.
29. Townsley MI, Korthuis RJ, Rippe B, Parker JC, Taylor AE. Validation of double vascular occlusion method for Pc,i in lung and skeletal muscle. J Appl Physiol 61: 127-132, 1986. (Pubitemid 16055667)
30. Tran QK, Watanabe H. Calcium signalling in the endothelium. Handb Exp Pharmacol 176: 145-187, 2006.
31. 2+-selective, store-operated current (ISOC) in endothelial cell permeability: determinants of the vascular leak site. Circ Res 96: 856-863, 2005.
32. 2+ channels mediate vaso-occlusion of sickled erythrocytes in lung microcirculation. Circ Res 93: 346-353, 2003.
33. Yin J, Hoffmann J, Kaestle SM, Neye N, Wang L, Baeurle J, Liedtke W, Wu S, Kuppe H, Pries AR, Kuebler WM. Negative-feedback loop attenuates hydrostatic lung edema via a cGMP-dependent regulation of transient receptor potential vanilloid 4. Circ Res 102: 966-974, 2008. (Pubitemid 351591552)
34. 1G) controls von Willebrand factor secretion in rat pulmonary microvascular endothelial cells. Am J Physiol Lung Cell Mol Physiol 292: L833-L844, 2007.
35. Zhou C, Wu S. T-type calcium channels in pulmonary vascular endothelium. Microcirculation 13: 645-656, 2006. (Pubitemid 44688422)