Facile and practical synthesis of a cannabinoid-1 antagonist via regio- and stereoselective ring-opening of an aziridinium ion

Tetrahedron

Volumn 65, Issue 45, 2009, Pages 9067-9074

  Villhauer, Edwin B ^a   Shieh, Wen Chung ^a   Du, Zhengming ^a   Vargas, Kevin ^a   Ciszewski, Lech ^a   Lu, Yansong ^a   Girgis, Michael ^a   Lin, Melissa ^a   Prashad, Mahavir ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Aziridinium ion; Imidazolidinone; Regioselective; Stereoselective; Vicinal diamine

Indexed keywords

3 [4 (4 CHLORO PHENOXY) PHENYL] 4 (3 TRIFLUOROMETHYL PHENYL) 1 (2 METHANESULFONYL ETHYL) IMIDAZOLIDIN 2 ONE; ANILINE; AZIRIDINE; CANNABINOID 1 RECEPTOR ANTAGONIST; DIAMINE; IMIDAZOLIDINE DERIVATIVE; MANDELIC ACID; NUCLEOPHILE; UNCLASSIFIED DRUG;

ARTICLE; CHROMATOGRAPHY; CRYSTALLIZATION; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RACEMIZATION; STEREOCHEMISTRY; SUBSTITUTION REACTION;

EID: 70349761374     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2009.09.054     Document Type: Article

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