Serum leptin level and its association with bone mineral density in obese children

Chinese Journal of Contemporary Pediatrics

Volumn 11, Issue 9, 2009, Pages 745-748

  Liu, Sai Qin ^a   Wu, Jing ^a   Mo, Juan ^a   Sun, Zhi Xiang ^a   Yang, Hao Bo ^a   Huang, Chao Wen ^a   Lei, Min Xiang ^a   Peng, Lie Wu ^a   Xu, Li ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Bone mineral density; Child; Leptin; Obesity

Indexed keywords

LEPTIN;

AGED; ARTICLE; BLOOD SAMPLING; BODY COMPOSITION; BODY FAT; BODY HEIGHT; BODY MASS; BODY WEIGHT; BONE DENSITY; CHILD; CLINICAL ASSESSMENT; CONTROLLED STUDY; DISEASE ASSOCIATION; DUAL ENERGY X RAY ABSORPTIOMETRY; ENZYME LINKED IMMUNOSORBENT ASSAY; FAT BODY; FEMALE; HUMAN; LEAN BODY WEIGHT; MAJOR CLINICAL STUDY; MALE; OBESITY; PRIMARY SCHOOL; PROTEIN BLOOD LEVEL; SCHOOL CHILD; WAIST CIRCUMFERENCE; WAIST HIP RATIO;

BODY COMPOSITION; BONE DENSITY; CHILD; FEMALE; HUMANS; LEPTIN; MALE; OBESITY; REGRESSION ANALYSIS; SEX CHARACTERISTICS;

EID: 70349733238     PISSN: 10088830     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Ji CY, Working Group on obesity in China (WGOC). Report on childhood obesity in China (4) prevalence and trends of overweight and obesity in Chinese urban school-age children and adolescents, 1985-2000[J]. Biomed Environ Sci, 2007, 20(1):1-10.
2. Cooper C, Harvey N, Javaid K, Hanson M, Dennison E. Growth and bone development[J]. Nestle Nutr Workshop Ser Pediatr Program, 2008, 61:53-68.
3. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue[J]. Nature, 1994, 372(6505):425-432. (Pubitemid 24365442)
4. Luo XH, Guo LJ, Yuan LQ, Xie H, Zhou HD, Wu XP, et al. Adiponectin stimulates human osteoblasts proliferation and differentiation via the MAPK signaling pathway[J]. Exp Cell Res, 2005,309(1):99-109. (Pubitemid 41191227)
5. Liu C, Grossmann A, Bain S, Strachan M, Puerner D, Bailey C, et al. Leptin stimulates cortical bone formation in obese mice[J]. J Bone Miner Res, 1997, 12(Suppl 1):S115.
6. Richards JB, Vakdes AM, Burling K, Perks UC, Spector TD. Serum adiponectin and bone mineral density in women[J]. J Clin Endocrinol Metab, 2007, 92(4):1517-1523. (Pubitemid 46556433)
7. Rocher E, Chappard C, Jaffre C, Benhamon C, Courteix D. Bone mineral density in prepubertal obese and control children: relation to body weight, lean mass and fat mass[J]. J Bone Miner Metab, 2008, 26(1):73-78. (Pubitemid 350307999)
8. Leonard MB, Shults J, Wilson BA, Tershakovec AM, Zemel BS. Obesity during childhood and aldolesence augments bone mass and bone dimensions[J]. Am J Clin Nutr, 2004, 80(2):514-523.
9. Reseland JE, Syversen U, Bakke I, Qviqstad G, Eide LG, Hjertner O, et al. Leptin is expressed in and secreted from primary cultures of human osteoblasts and promotes bone mineralization[J]. J Bone Miner Res, 2001, 16(8):1426-1433. (Pubitemid 32675194)
10. Ducy P, Amling M, Takeda S, Priemel M, Schilling AF, Beil FT, et al. Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass[J]. Cell, 2000, 100(2):197-207. (Pubitemid 30064908)
11. Chanprasertyothin S, Piaseu N, Chailurkit L, Rajatanavin R, Ongphiphadhanakul B. Association of circulating leptin with bone mineral density in males and females[J]. J Med Assoc Thai, 2005, 88(5):655-659. (Pubitemid 41073262)
12. Ruhl CE, Everhart JE. Relationship of serum leptin concentration with bone mineral density in the United States population[J]. J Bone Miner Res, 2002, 17(10):1896-1903.
13. Wosje KS, Binkley TL, Kalkwarf HJ, Specker BL. Relationships between bone mass and circulating leptin concentrations in Hutterites[J]. Bone, 2004, 34(6):1017-1022. (Pubitemid 38749239)
14. Pasco J, Henry MJ, Kotowicz MA, Collier GR, Ball MJ, Ugoni AM, et al. Serum leptin levels are associated with bone mass in nonobese women[J]. J Clin Endocrinol Metab, 2001, 86(5):1884-1887. (Pubitemid 32472890)
15. Ibáñez L, Potau N, Ong K, Dünger DB, De Zegher FD. Increased bone mineral density and serum leptin in non-obese girls with precocious pubarche: relation to low birthweight and hyperin-sulinism[J]. Horm Res, 2000, 54(4):192-197.
16. Kontogianni MD, Dafni UG, Routsias JG, Skopouli FN. Blood leptin and adiponectin as possible mediators of the relation between fat mass and BMD in perimenopausal women[J]. J Bone Miner Res, 2004, 19(4):546-551.
17. Holloway WR, Collier FM, Atiken CJ, Myers DE, Hodge JM, Malakellis M, et al. Leptin inhibits osteoclast generation[J]. J Bone Miner Res, 2002, 17(2):200-209.