Bilateral reorganization of the dentate gyrus in hippocampal sclerosis: A postmortem study

Neurology

Volumn 73, Issue 13, 2009, Pages 1033-1040

  Thom, M ^a,c   Martinian, L ^a   Catarino, C ^a,b   Yogarajah, M ^a,b   Koepp, M J ^a,b   Caboclo, L ^a   Sisodiya, S M ^a,b  

^a NATIONAL HOSPITAL FOR NEUROLOGY AND NEUROSURGERY   (United Kingdom)

^b EPILEPSY SOCIETY   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DYNORPHIN; NEUROPEPTIDE;

ADULT; AGED; ARTICLE; AUTOPSY; DENTATE GYRUS; EPILEPSY; HIPPOCAMPAL SCLEROSIS; HISTOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MOSSY FIBER; NERVE SPROUTING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REMISSION; SEIZURE; SYNAPSE; TEMPORAL LOBE EPILEPSY;

EID: 70349693957     PISSN: 00283878     EISSN: 1526632X     Source Type: Journal    
DOI: 10.1212/WNL.0b013e3181b99a07     Document Type: Article

References (29)

1. Meencke HJ, Veith G, Lund S. Bilateral hippocampal sclerosis and secondary epileptogenesis. Epilepsy Res Suppl 1996;12:335-342.
2. Margerison JH, Corsellis JA. Epilepsy and the temporal lobes: a clinical, electroencephalographic and neuropatho-logical study of the brain in epilepsy, with particular reference to the temporal lobes. Brain 1966;89:499-530.
3. Tellez-Zenteno JF, Dhar R, Wiebe S. Long-term seizure outcomes following epilepsy surgery: a systematic review and meta-analysis. Brain 2005;128:1188-1198.
4. Keller SS, Cresswell P, Denby C, et al. Persistent seizures following left temporal lobe surgery are associated with posterior and bilateral structural and functional brain abnormalities. Epilepsy Res 2007;74:131-139.
5. Halasz P, Janszky J, Rasonyi GY, et al. Postoperative inter-ictal spikes during sleep contralateral to the operated side is associated with unfavourable surgical outcome in patients with preoperative bitemporal spikes. Seizure 2004;13: 460-466.
6. Arabadzisz D, Antal K, Parpan F, Emri Z, Fritschy JM. Epileptogenesis and chronic seizures in a mouse model of temporal lobe epilepsy are associated with distinct EEG patterns and selective neurochemical alterations in the contralateral hippocampus. Exp Neurol 2005;194: 76-90.
7. Nadler JV. The recurrent mossy fiber pathway of the epileptic brain. Neurochem Res 2003;28:1649-1658.
8. de Lanerolle NC, Kim JH, Williamson A, et al. A retrospective analysis of hippocampal pathology in human temporal lobe epilepsy: evidence for distinctive patient subcategories. Epilepsia 2003;44:677-687.
9. Houser CR. Granule cell dispersion in the dentate gyrus of humans with temporal lobe epilepsy. Brain Res 1990;535: 195-204.
10. Blumcke I, Pauli E, Clusmann H, et al. A new clinico-pathological classification system for mesial temporal sclerosis. Acta Neuropathol (Berl) 2007;113:235-244.
11. Thom M, Zhou J, Martinian L, Sisodiya S. Quantitative post-mortem study of the hippocampus in chronic epilepsy: seizures do not inevitably cause neuronal loss. Brain 2005;128:1344-1357.
12. Mathern GW, Babb TL, Pretorius JK, Leite JP. Reactive synaptogenesis and neuron densities for neuropeptide Y, somatostatin, and glutamate decarboxylase immunoreac-tivity in the epileptogenic human fascia dentata. J Neuro-sci 1995;15:3990-4004.
13. Houser CR, Miyashiro JE, Swartz BE, Walsh GO, Rich JR, Delgado-Escueta AV. Altered patterns of dynorphin immunoreactivity suggest mossy fiber reorganization in human hippocampal epilepsy. J Neurosci 1990;10:267-282.
14. Wieser HG. ILAE Commission Report. Mesial temporal lobe epilepsy with hippocampal sclerosis. Epilepsia 2004; 45:695-714.
15. Zhang N, Houser CR. Ultrastructural localization of dynorphin in the dentate gyrus in human temporal lobe epilepsy: a study of reorganized mossy fiber synapses. J Comp Neurol 1999;405:472-490.
16. Mathern GW, Pretorius JK, Babb TL, Quinn B. Unilateral hippocampal mossy fiber sprouting and bilateral asymmetric neuron loss with episodic postictal psychosis. J Neurosurg 1995;82:228-233.
17. Sutula T, Cascino G, Cavazos J, Parada I, Ramirez L. Mossy fiber synaptic reorganization in the epileptic human temporal lobe. Ann Neurol 1989;26:321-330.
18. Cavazos JE, Golarai G, Sutula TP. Mossy fiber synaptic reorganization induced by kindling: time course of development, progression, and permanence. J Neurosci 1991;11:2795-2803.
19. Sutula TP, Dudek FE. Unmasking recurrent excitation generated by mossy fiber sprouting in the epileptic dentate gyrus: an emergent property of a complex system. Prog Brain Res 2007;163:541-563.
20. Gorter JA, van Vliet EA, Aronica E, Lopes da Silva FH. Progression of spontaneous seizures after status epilepticus is associated with mossy fibre sprouting and extensive bilateral loss of hilar parvalbumin and somatostatin-immunoreactive neurons. Eur J Neurosci 2001;13:657-669.
21. Bouilleret V, Ridoux V, Depaulis A, Marescaux C, Nehlig A, Le Gal La Salle G. Recurrent seizures and hippocampal sclerosis following intrahippocampal kainate injection in adult mice: electroencephalography, histopathology and synaptic reorganization similar to mesial temporal lobe epilepsy. Neuroscience 1999;89:717-729.
22. Elmer E, Kokaia Z, Kokaia M, Lindvall O, McIntyre DC. Mossy fibre sprouting: evidence against a facilitatory role in epileptogenesis. Neuroreport 1997;8:1193-1196.
23. de Lanerolle NC, Kim JH, Robbins RJ, Spencer DD. Hippocampal interneuron loss and plasticity in human temporal lobe epilepsy. Brain Res 1989;495:387-395.
24. Dube C. Neuropeptide Y: potential role in recurrent developmental seizures. Peptides 2007;28:441-446.
25. Nadler JV, Tu B, Timofeeva O, Jiao Y, Herzog H. Neu-ropeptide Y in the recurrent mossy fiber pathway. Peptides 2007;28:357-364.
26. Vezzani A, Sperk G. Overexpression of NPY and Y2 receptors in epileptic brain tissue: an endogenous neuroprotec-tive mechanism in temporal lobe epilepsy? Neuropeptides 2004;38:245-252.
27. Tu B, Timofeeva O, Jiao Y, Nadler JV. Spontaneous release of neuropeptide Y tonically inhibits recurrent mossy fiber synaptic transmission in epileptic brain. J Neurosci 2005;25:1718-1729.
28. Furtinger S, Pirker S, Czech T, Baumgartner C, Ransmayr G, Sperk G. Plasticity of Y1 and Y2 receptors and neu-ropeptide Y fibers in patients with temporal lobe epilepsy. J Neurosci 2001;21:5804-5812.
29. Sundstrom LE, Brana C, Gatherer M, Mepham J, Rougier A. Somatostatin-and neuropeptide Y-synthesizing neurones in the fascia dentata of humans with temporal lobe epilepsy. Brain 2001;124:688-697.