JAK-STAT signal inhibition regulates competition in the drosophila testis stem cell niche

Science

Volumn 326, Issue 5949, 2009, Pages 153-156

  Lssigonis, Melanie ^a   Tulina, Natalia ^b   De Cuevas, Margaret ^a   Brawley, Crista ^c   Sandler, Laurel ^a   Matunist, Erika ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTEGRIN; JANUS KINASE; STAT PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING; SUPPRESSOR OF CYTOKINE SIGNALING 36E; UNCLASSIFIED DRUG;

FLY; GENE EXPRESSION; GERM CELL; HORMONE; INHIBITION; PROTEIN;

ANIMAL CELL; ARTICLE; CELL ADHESION; CELL POPULATION; CELL TYPE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DROSOPHILA; GERM LINE; INTERSPECIFIC COMPETITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN TARGETING; SIGNAL TRANSDUCTION; SOMATIC CELL; STEM CELL; TESTIS CELL;

ANIMALS; CELL ADHESION; CELL COUNT; DROSOPHILA; DROSOPHILA PROTEINS; GERM CELLS; INTEGRINS; JANUS KINASES; MALE; MUTAGENESIS, INSERTIONAL; SIGNAL TRANSDUCTION; STAT TRANSCRIPTION FACTORS; STEM CELL NICHE; STEM CELLS; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; TESTIS;

EID: 70349690282     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1176817     Document Type: Article

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30. We thank the Bloomington Stock Center, Developmental Studies Hybridoma Bank, and members of the fly community for reagents; M. Sepanski for electron microscopy; M. Gold for inverse polymerase chain reaction; B. Ohlstein, M. Wawersik, and M. Matunis for helpful comments; and J. Leatherman and S. DiNardo for sharing unpublished data. This work was supported by NIH grant RO1HD40307 (to E.M.) and Basil O'Connor/March of Dimes grant 5-FY02-285 (to M.C.). The authors have no conflicts of interest.