PAR4: A new role in the modulation of visceral nociception

Neurogastroenterology and Motility

Volumn 21, Issue 11, 2009, Pages 1129-1132

  Bradesi, S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Protease activated receptors 4; Sensory neurons; Visceral nociception

Indexed keywords

ALLYL ISOTHIOCYANATE; PROTEINASE ACTIVATED RECEPTOR 4; VANILLOID RECEPTOR 4;

CALCIUM MOBILIZATION; COLON DILATATION; CONTROLLED STUDY; HYPERALGESIA; HYPERSENSITIVITY; INFLAMMATION; IRRITABLE COLON; MODULATION; MOUSE; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; SENSORY NERVE; SENSORY NERVE CELL; SHORT SURVEY; VISCERAL PAIN;

ANIMALS; COLON; HUMANS; IRRITABLE BOWEL SYNDROME; MICE; PAIN; RECEPTOR, PAR-2; RECEPTORS, THROMBIN; TRPV CATION CHANNELS; VISCERAL AFFERENTS;

EID: 70349673027     PISSN: 13501925     EISSN: 13652982     Source Type: Journal    
DOI: 10.1111/j.1365-2982.2009.01373.x     Document Type: Short Survey

References (20)

1. Vu TK, Wheaton VI, Hung DT, Charo I, Coughlin SR. Domains specifying thrombin-receptor interaction. Nature 1991 353 : 674 677.
2. Nystedt S, Emilsson K, Wahlestedt C, Sundelin J. Molecular cloning of a potential proteinase activated receptor. Proc Natl Acad Sci USA 1994 91 : 9208 9212.
3. Ishihara H, Connolly AJ, Zeng D et al. Protease-activated receptor 3 is a second thrombin receptor in humans. Nature 1997 386 : 502 506.
4. Kahn ML, Zheng YW, Huang W et al. A dual thrombin receptor system for platelet activation. Nature 1998 394 : 690 694.
5. Xu WF, Andersen H, Whitmore TE et al. Cloning and characterization of human protease-activated receptor 4. Proc Natl Acad Sci USA 1998 95 : 6642 6646.
6. 4): a role as inhibitor of visceral pain and hypersensitivity. Neurogastroenterol Motil 2009 21 : 1189 e107.
7. Kawabata A, Saifeddine M, al-Ani B, Hollenberg MD. Protease-activated receptors: development of agonists selective for receptors triggered by either thrombin (PAR1) or trypsin (PAR2). Proc West Pharmacol Soc 1997 40 : 49 51.
8. Ramachandran R, Hollenberg MD. Proteinases and signalling: pathophysiological and therapeutic implications via PARs and more. Br J Pharmacol 2008 1 : S263 282.
9. Ossovskaya VS, Bunnett NW. Protease-activated receptors: contribution to physiology and disease. Physiol Rev 2004 84 : 579 621.
10. Nguyen C, Coelho AM, Grady E et al. Colitis induced by proteinase-activated receptor-2 agonists is mediated by a neurogenic mechanism. Can J Physiol Pharmacol 2003 81 : 920 927.
11. Kawabata A, Oono Y, Yonezawa D et al. 2-Furoyl-LIGRL-NH2, a potent agonist for proteinase-activated receptor-2, as a gastric mucosal cytoprotective agent in mice. Br J Pharmacol 2005 144 : 212 219.
12. Fiorucci S, Mencarelli A, Palazzetti B et al. Proteinase-activated receptor 2 is an anti-inflammatory signal for colonic lamina propria lymphocytes in a mouse model of colitis. Proc Natl Acad Sci USA 2001 98 : 13936 13941.
13. Vergnolle N. Modulation of visceral pain and inflammation by protease-activated receptors. Br J Pharmacol 2004 141 : 1264 1274.
14. Vergnolle N, Derian CK, D'Andrea MR, Steinhoff M, Andrade-Gordon P. Characterization of thrombin-induced leukocyte rolling and adherence: a potential proinflammatory role for proteinase-activated receptor-4. J Immunol 2002 169 : 1467 1473.
15. Houle S, Papez MD, Ferazzini M, Hollenberg MD, Vergnolle N. Neutrophils and the kallikrein-kinin system in proteinase-activated receptor 4-mediated inflammation in rodents. Br J Pharmacol 2005 146 : 670 678.
16. Asfaha S, Cenac N, Houle S et al. Protease-activated receptor-4: a novel mechanism of inflammatory pain modulation. Br J Pharmacol 2007 150 : 176 185.
17. McDougall JJ, Zhang C, Cellars L, Joubert E, Dixon CM, Vergnolle N. Triggering of proteinase-activated receptor 4 leads to joint pain and inflammation in mice. Arthritis Rheum 2009 60 : 728 737.
18. Oikonomopoulou K, Hansen KK, Saifeddine M et al. Proteinase-activated receptors, targets for kallikrein signaling. J Biol Chem 2006 281 : 32095 32112.
19. Cenac N, Andrews CN, Holzhausen M et al. Role for protease activity in visceral pain in irritable bowel syndrome. J Clin Invest 2007 117 : 636 647.
20. Antalis TM, Shea-Donohue T, Vogel SN, Sears C, Fasano A. Mechanisms of disease: protease functions in intestinal mucosal pathobiology. Nat Clin Pract Gastroenterol Hepatol 2007 4 : 393 402.