Effect of processing on the chemical contents and hepatic and renal toxicity of rhubarb studied by canonical correlation analysis

Yaoxue Xuebao

Volumn 44, Issue 8, 2009, Pages 885-890

  Wang, Jia Bo ^a   Ma, Yong Gang ^a,b   Zhang, Ping ^a   Jin, Cheng ^a   Sun, Yu Qi ^a   Xiao, Xiao He ^a   Zhao, Yan Ling ^a   Zhou, Can Ping ^a  

^a 302 MILITARY HOSPITAL   (China)

^b XIYUAN HOSPITAL   (China)

Author keywords

Anthraquinones; Canonical correlation analysis; Hepatic and renal toxicity; Rhubarb; Tannins; Toxicity attenuating effect of processing

Indexed keywords

ALOE EMODIN; ANTHRAQUINONE DERIVATIVE; CHRYSOPHANIC ACID; CREATINE; EMODIN; PHYSCION; RHEIN; TANNIN DERIVATIVE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; CORRELATION ANALYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIVER TOXICITY; MOUSE; NEPHROTOXICITY; NONHUMAN; PROCESSING; RHUBARB; SPECTROPHOTOMETER; TOXICITY TESTING;

ALANINE TRANSAMINASE; ANIMALS; ANTHRAQUINONES; CREATININE; KIDNEY; LIVER; MICE; PLANT ROOTS; PROANTHOCYANIDINS; RHEUM; TECHNOLOGY, PHARMACEUTICAL;

EID: 70349664272     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. WHO Monographs on Selected Medicinal Plants [M]. Geneva: World Health Organization, 1999: 231-240.
2. Wang JB, Jin C, Li HF, et al. Essential issues of bioassay methods for quality control of laxative traditional Chinese medicines [J]. Acta Pharm Sin, 2009, 44: 500-505.
3. He FL, Wang L, Zhang XK, et al. Emodin induces apoptosis of cancer cells and inhibits retinoid X receptor transcriptional activity [J]. Acta Pharm Sin, 2008, 43: 350-355.
4. Zheng HY, Hu JD, Zheng ZH, et al. Emodin induces leukemic HL-60 cells apoptosis probably by inhibiting Akt signal pathway [J]. Acta Pharm Sin, 2007, 42: 1142-1146.
5. Xu ZJ, Huang YQ, Zhang QH, et al. Clinical study on rhubarb in the treatment of chronic hepatic fibrosis [J]. Chin J Infect Dis, 2004, 22: 202-203.
6. Wang TM, Qiu B, Li SM, et al. Clinical study on rhubarb powders in the treatment of hepatic encephalopathy of 60 patients [J]. Chin J Integr Tradit Chin West Med, 2008, 28: 558-559.
7. Xu LC, Xia LM, Bian YP. Clinical study on rhubarb in the treatment of bilirubinemia caused by viral hepatitis [J]. Mod J Integr Tradit Chin West Med, 2006, 15: 725.
8. Liu L, Li BL, Zhou SY, et al. Effects of Tanguficum Maxim polysaccharides in acute liver injury of mice [J]. J Fourth Mil Med Univ, 1999, 20: 549-551.
9. Li L. End-stage renal disease in China [J]. Kidney Int, 1996, 49: 287-301
10. Li XM, Wang HY. Chinese herbal medicine in the treatment of chronic kidney disease [J]. Adv Chronic Kidney Dis, 2005, 12: 276-281. (Pubitemid 40931933)
11. Zhao YL, Wang JB, Zhou GD, et al. Investigations of free andiraquinones from rhubarb against α-naphthylisothiocyanate-induced cholestatic liver injury in rats [J]. Basic Clin Pharmacol Toxicol, 2009, 104: 463-469.
12. Wang CF, Wu XD, Chen M, et al. Emodin induces apoptosis through caspase 3-dependent pathway in HK-2 cells [J]. Toxicol, 2007, 231: 120-128. (Pubitemid 46283155)
13. Zhang LY, Jiang ZZ, Pu CH, et al. Six-month oral toxicity study of total anthraquinone in Radix et Rhizoma Rhei in SD rats [J]. Chin J Biochem Pharm, 2004, 25: 206-209.
14. Wang JB, Zhao YL, Xiao XH, et al. Assessment of the renal protection and hepatotoxicity of rhubarb extract in rats [J]. J Ethnopharmacol, 2009, 121: 18-25.
15. Zhu ST, Lei P, Li XZ, et al. Comparative study on laxative and hemostasis of different processed materials of the radix of Rheum palmatum L. [J]. J Chin Med Mater, 2008, 31: 199-201.
16. Zhong HJ. The clinical application of the processed rhubarb and the processing methods [J]. Lishizhen Med Mater Med Res, 2004, 15: 409.
17. Sun YQ, Xiao XH, Ma YG, et al. Study on dynamic variation patterns of anthraquinones of Radix et Rhiroma Rhei at different decocting time [J]. Pharm J Chin PLA, 2006, 22: 281-283.
18. Hu LP. Practical Analysis Courses of Windows SAS 6.12& 8.0 [M]. Beijing: Military Medical Science Press, 2001.
19. Meselhy MR, Nishimoto E, Akao T, et al. Human intestinal Bacteroides spp. RHEIN-I and RHEIN-II capable of transforming rhein to rheinanthrone, induce rhein-dependent diarrhea in rats [J]. J Trad Med, 2001, 18: 169-176.
20. Ding MY, Ni WW. Separation of tannins in rhubarb and its analysis by high performance liquid chromatography-mass spectrometry [J]. Chin J Chromatogr (felt), 2004, 22: 605-608.
21. 4-induced liver injury [J]. J Guangxi Coll Tradit Chin Med Univ, 1999, 16: 129-131.