Anti-angiogenic activity of carebastine: A plausible mechanism affecting airway remodelling

European Respiratory Journal

Volumn 34, Issue 4, 2009, Pages 958-966

  De Luisi, A ^a   Mangialardi, G ^d   Ria, R ^a   Acuto, G ^c   Ribatti, D ^b   Vacca, A ^a  

^a POLICLINICO   (Italy)

^b UNIVERSITY OF BARI MEDICAL SCHOOL   (Italy)

^c Almirall ^*  (Italy)

^d UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

Allergic diseases; Anti angiogenesis; Asthma; Carebastine; Ebastine; Endothelial cells

Indexed keywords

CAREBASTINE; EBASTINE; HISTAMINE H1 RECEPTOR; PROTEIN KINASE B; VASCULOTROPIN RECEPTOR; VASCULOTROPIN RECEPTOR 2;

AIRWAY; ALLERGIC DISEASE; ANGIOGENESIS; ANIMAL CELL; ANTIANGIOGENIC ACTIVITY; ARTICLE; BASEMENT MEMBRANE; CAPILLARY; CELL MIGRATION; CELL PROLIFERATION; CHICK EMBRYO; CHORIOALLANTOIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; EMBRYO; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; METABOLITE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PULMONARY ARTERY; TISSUE REPAIR; UMBILICAL VEIN; WESTERN BLOTTING;

AIRWAY REMODELING; ANIMALS; ANTI-ASTHMATIC AGENTS; BUTYROPHENONES; CAPILLARIES; CELL DIVISION; CELL MOVEMENT; CELLS, CULTURED; CHICK EMBRYO; CHICKENS; CHORIOALLANTOIC MEMBRANE; ENDOTHELIAL CELLS; HUMANS; NEOVASCULARIZATION, PATHOLOGIC; PHOSPHORYLATION; PIPERIDINES; PROTO-ONCOGENE PROTEINS C-AKT; PULMONARY ARTERY; RECEPTORS, HISTAMINE H1; SIGNAL TRANSDUCTION; UMBILICAL VEINS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 70349646746     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00165308     Document Type: Article

References (35)

1. Hayashi S, Hashimoto S. Anti-inflammatory actions of new antihistamines. Clin Exp Allergy 1999; 29: 1593-1596.
2. Leurs R, Church MK, Tagliatela M. H1-antihistamines: inverse agonism, anti-inflammatory actions and cardiac effects. Clin Exp Allergy 2002; 32: 489-498. (Pubitemid 34429565)
3. 4 mediates histamine induction of NF-κB and IL-8 in human bronchial epithelial cells. Am J Physiol 1998; 274: L1030-L1039.
4. 1 receptor to the nucleus. Mol Pharmacol 2001; 59: 1012-1021.
5. Arnold R, Rihoux J, Konig WQ. Cetirizine counter-regulates interleukin-8 release from human epithelial cells (A549). Clin Exp Allergy 1999; 29: 1681-1691.
6. Papi A, Papadopoulos NG, Stanciu LA, et al. Effect of desloratadine and loratadine on rhinovirus-induced intercellular adhesion molecule 1 upregulation and promoter activation in respiratory epithelial cells. J Allergy Clin Immunol 2001; 108: 221-228. (Pubitemid 32735405)
7. Yoneda K, Yamamoto T, Ueta E, et al. Suppression by azelastine hydrochloride of NF-kB activation involved in generation of cytokines and nitric oxide. Jpn J Pharmacol 1997; 73: 145-153. (Pubitemid 27129738)
8. Nori M, Iwata S, Munakata Y, et al. Ebastine inhibits T cell migration, production of Th2-type cytokines and proinflammatory cytokines. Clin Exp Allergy 2003; 33: 1544-1554. (Pubitemid 37421633)
9. McDonald DM. Imaging of angiogenesis in inflammation and cancer: lessons for novel treatment of allergic rhinitis. Clin Exp Allergy Reviews 2007; 7: 11-18.
10. Walters EH, Reid D, Soltani A, et al. Angiogenesis: a potentially critical part of remodelling in chronic airway diseases? Pharmacol Ther 2008; 118: 128-137.
11. Wilson J. The bronchial microcirculation in asthma. Clin Exp Allergy 2000; 30: 51-53.
12. Yuksel H, Kose C, Yilmaz O, et al. Increased expression of tissue vascular endothelial growth factor and foetal liver kinase-1 receptor in seasonal allergic rhinitis and relevance to asthma component. Clin Exp Allergy 2007; 37: 1183-1188. (Pubitemid 47076346)
13. Kuwano K, Bosken CH, Paré PD, et al. Small airways dimensions in asthma and in chronic obstructive pulmonary disease. Am Rev Respir Dis 1993; 148: 1220-1225. (Pubitemid 23326017)
14. Li X, Wilson JW. Increased vascularity of the bronchial mucosa in mild asthma. Am J Respir Crit Care Med 1997; 156: 229-233. (Pubitemid 27293194)
15. Salvato G. Quantitative and morphological analysis of the vascular bed in bronchial biopsy specimens from asthmatic and non-asthmatic subjects. Thorax 2001; 56: 902-906. (Pubitemid 33097183)
16. Hoshino M, Takahashi M, Aoike N. Expression of vascular endothelial growth factor, basic fibroblast growth factor, and angiogenin immunoreactivity in asthmatic airways and its relationship to angiogenesis. J Allergy Clin Immunol 2001; 107: 295-301. (Pubitemid 32173907)
17. Orsida BE, Li X, Hickley B, et al. Vascularity in asthmatic airways: relation to inhaled steroid dose. Thorax 1999; 54: 289-295. (Pubitemid 29150155)
18. Hashimoto M, Tanaka H, Abe S. Quantitative analysis of bronchial wall vascularity in the medium and small airways of patients with asthma and COPD. Chest 2005; 127: 965-972. (Pubitemid 40775530)
19. Feltis BN, Wignarajah D, Zheng L, et al. Increased vascular endothelial growth factor and receptors: relation to angiogenesis in asthma. Am J Respir Crit Care Med 2006; 173: 1201-1207. (Pubitemid 43848389)
20. Feltis BN, Wignarajah D, Reid DW, et al. Effects of inhaled fluticasone on angiogenesis and vascular endothelial growth factor in asthma. Thorax 2007; 62: 314-319. (Pubitemid 46580574)
21. Redington AE, Roche WR, Madden J, et al. Basic fibroblast growth factor in asthma: measurement in broncholaveolar lavage fluid basally and following allergen challenge. J Allergy Clin Immunol 2001; 107: 384-387. (Pubitemid 32173920)
22. Simcock DE, Kanabar V, Clarke GW, et al. Proangiogenic activity in bronchoalveolar lavage fluid from patients with asthma. Am J Respir Crit Care Med 2007; 176: 146-153. (Pubitemid 47057850)
23. H2-mediated sensitization and inflammation in the lung. Nat Med 2004; 10: 1095-1103.
24. Vacca A, Ribatti D, Presta M, et al. Bone marrow neovascularization, plasma cell angiogenic potential, and matrix metalloproteinase-2 secretion parallel progression of human multiple myeloma. Blood 1999; 93: 3064-3073. (Pubitemid 29200799)
25. Kueng W, Silber E, Eppenberger U. Quantification of cells cultured on 96-well plates. Anal Biochem 1989; 182: 16-19. (Pubitemid 19251274)
26. Scavelli C, Di Pietro G, Cirulli T, et al. Zoledronic acid impacts over-angiogenic phenotype of endothelial cells in patients with multiple myeloma. Mol Cancer Ther 2007; 6: 3256-3262.
27. Guidolin D, Vacca A, Nussdorfer GG, et al. A new image analysis method based on topological and fractal parameters to evaluate the angiostatic activity of docetaxel by using the Matrigel assay in vitro. Microvasc Res 2004; 67: 117-124. (Pubitemid 38326997)
28. Ribatti D, Nico B, Vacca A, et al. The gelatin sponge-chorioallantoic membrane assay. Nat Protoc 2006; 1: 85-91.
29. 1 receptor itself through activation of receptor gene transcription. J Pharmacol Sci 2007; 103: 374-382.
30. 1-receptor gene transcription. J Pharm Pharmacol 2007; 59: 843-848.
31. Puxeddu I, Alian A, Piliponski AM, et al. Human peripheral blood eosinophils induce angiogenesis. Int J Biochem Cell Biol 2005; 37: 628-636. (Pubitemid 40022939)
32. Puxeddu I, Ribatti D, Crivellato E, et al. Mast cells and eosinophils: a novel link between inflammation and angiogenesis in allergic diseases. J Allergy Clin Immunol 2005; 116: 531-536. (Pubitemid 41267124)
33. Chetta A, Zanini A, Foresi A, et al. Vascular endothelial growth factor up-regulation and bronchial wall remodelling in asthma. Clin Exp Allergy 2005; 35: 1437-1442. (Pubitemid 43919805)
34. Asai K, Kanazawa H, Otani K, et al. Imbalance between vascular endothelial growth factor and endostatin levels in induced sputum from asthmatic subjects. J Allergy Clin Immunol 2002; 110: 571-575. (Pubitemid 35178791)
35. Simcock DE, Kanabar V, Clarke GW, et al. Induction of angiogenesis by airway smooth muscle from patients with asthma. Am J Respir Crit Care Med 2008; 178: 460-468.