메뉴 건너뛰기




Volumn 33, Issue 11, 2003, Pages 1544-1554

Ebastine inhibits T cell migration, production of Th2-type cytokines and proinflammatory cytokines

Author keywords

CD26; CD28; CD3; Ebastine; IL 4; IL 5; IL 6; T cell co stimulation; T cell migration; TNF

Indexed keywords

CYTOKINE; EBASTINE; GAMMA INTERFERON; HISTAMINE H1 RECEPTOR ANTAGONIST; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; THYMIDINE; TUMOR NECROSIS FACTOR ALPHA;

EID: 10744223108     PISSN: 09547894     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2222.2003.01701.x     Document Type: Article
Times cited : (28)

References (47)
  • 1
    • 0029740237 scopus 로고    scopus 로고
    • Clinical studies of the efficacy and tolerability of ebastine 10 or 20 mg once daily in the treatment of seasonal allergic rhinitis in the US
    • Storms WW. Clinical studies of the efficacy and tolerability of ebastine 10 or 20 mg once daily in the treatment of seasonal allergic rhinitis in the US. Drugs 1996; 52(Suppl 1):20-5.
    • (1996) Drugs , vol.52 , Issue.1 SUPPL. , pp. 20-25
    • Storms, W.W.1
  • 2
    • 0029760332 scopus 로고    scopus 로고
    • Double-blind multicentre comparative study of ebastine, terfenadine and placebo in the treatment of chronic idiopathic urticaria in adults
    • Kalis B. Double-blind multicentre comparative study of ebastine, terfenadine and placebo in the treatment of chronic idiopathic urticaria in adults. Drugs 1996; 52(Suppl 1):30-4.
    • (1996) Drugs , vol.52 , Issue.1 SUPPL. , pp. 30-34
    • Kalis, B.1
  • 3
    • 0033003121 scopus 로고    scopus 로고
    • Pharmacokinetic-pharmacodynamic analysis of the arrhythmogenic potency of a novel antiallergic agent, ebastine, in rats
    • Ohtani H, Sato H, Iga T, Kotaki H, Sawada Y. Pharmacokinetic- pharmacodynamic analysis of the arrhythmogenic potency of a novel antiallergic agent, ebastine, in rats. Biopharm Drug Dispos 1999; 20:101-6.
    • (1999) Biopharm Drug Dispos , vol.20 , pp. 101-106
    • Ohtani, H.1    Sato, H.2    Iga, T.3    Kotaki, H.4    Sawada, Y.5
  • 4
    • 0034826856 scopus 로고    scopus 로고
    • Effects of supratherapeutic doses of ebastine and terfenadine on the QT interval
    • Gillen MS, Miller B, Chaikin P, Morganroth J. Effects of supratherapeutic doses of ebastine and terfenadine on the QT interval. Br J Clin Pharmacol 2001; 52:201-4.
    • (2001) Br J Clin Pharmacol , vol.52 , pp. 201-204
    • Gillen, M.S.1    Miller, B.2    Chaikin, P.3    Morganroth, J.4
  • 5
    • 0004511968 scopus 로고    scopus 로고
    • Assessing the cardiac safety of ebastine. Epilogue
    • Roberts DJ. Assessing the cardiac safety of ebastine. Epilogue. Drug Saf 1999; 21(Suppl 1):89-92.
    • (1999) Drug Saf , vol.21 , Issue.1 SUPPL. , pp. 89-92
    • Roberts, D.J.1
  • 6
    • 0029770651 scopus 로고    scopus 로고
    • A preclinical overview of ebastine. Studies on the pharmacological properties of a novel histamine H1 receptor antagonist
    • Roberts DJ. A preclinical overview of ebastine. Studies on the pharmacological properties of a novel histamine H1 receptor antagonist. Drugs 1996; 52(Suppl 1):8-14.
    • (1996) Drugs , vol.52 , Issue.1 SUPPL. , pp. 8-14
    • Roberts, D.J.1
  • 7
    • 0025579171 scopus 로고
    • The effects of antihistamines beyond H1 antagonism in allergic inflammation
    • Massey WA, Lichtenstein LM. The effects of antihistamines beyond H1 antagonism in allergic inflammation. J Allergy Clin Immunol 1990; 86:1019-24.
    • (1990) J Allergy Clin Immunol , vol.86 , pp. 1019-1024
    • Massey, W.A.1    Lichtenstein, L.M.2
  • 8
    • 0030036654 scopus 로고    scopus 로고
    • Inhibition of mediator and cytokine release from dispersed nasal polyp cells by terfenadine
    • Crampette L, Mainprice B, Bloom M, Bousquet J, Campbell AM. Inhibition of mediator and cytokine release from dispersed nasal polyp cells by terfenadine. Allergy 1996; 51:346-9.
    • (1996) Allergy , vol.51 , pp. 346-349
    • Crampette, L.1    Mainprice, B.2    Bloom, M.3    Bousquet, J.4    Campbell, A.M.5
  • 10
    • 0028288179 scopus 로고
    • Lymphokine production by human T cells in disease states
    • Romagnani S. Lymphokine production by human T cells in disease states. Annu Rev Immunol 1994; 12:227-57.
    • (1994) Annu Rev Immunol , vol.12 , pp. 227-257
    • Romagnani, S.1
  • 11
    • 0027197709 scopus 로고
    • Allergen exposure induces the activation of allergen-specific Th2 cells in the airway mucosa of patients with allergic respiratory disorders
    • Del Prete GF, De Carli M, D'Elios MM et al. Allergen exposure induces the activation of allergen-specific Th2 cells in the airway mucosa of patients with allergic respiratory disorders. Eur J Immunol 1993; 23:1445-9.
    • (1993) Eur J Immunol , vol.23 , pp. 1445-1449
    • Del Prete, G.F.1    De Carli, M.2    D'Elios, M.M.3
  • 12
    • 0027320031 scopus 로고
    • + T cells, increased TH2-type cytokine mRNA expression, and eosinophil recruitment in bronchoalveolar lavage after allergen inhalation challenge in patients with atopic asthma
    • + T cells, increased TH2-type cytokine mRNA expression, and eosinophil recruitment in bronchoalveolar lavage after allergen inhalation challenge in patients with atopic asthma. J Allergy Clin Immunol 1993; 92:313-24.
    • (1993) J Allergy Clin Immunol , vol.92 , pp. 313-324
    • Robinson, D.1    Hamid, Q.2    Bentley, A.3    Ying, S.4    Kay, A.B.5    Durham, S.R.6
  • 13
    • 0026024576 scopus 로고
    • Accumulation of Th-2-like helper T cells in the conjunctiva of patients with vernal conjunctivitis
    • Maggi E, Biswas P, Del Prete G et al. Accumulation of Th-2-like helper T cells in the conjunctiva of patients with vernal conjunctivitis. J Immunol 1991; 146:1169-74.
    • (1991) J Immunol , vol.146 , pp. 1169-1174
    • Maggi, E.1    Biswas, P.2    Del Prete, G.3
  • 14
    • 0029060824 scopus 로고
    • T-cell activation: Integration of signals from the antigen receptor and costimulatory molecules
    • Robey E, Allison JP. T-cell activation: integration of signals from the antigen receptor and costimulatory molecules. Immunol Today 1995; 16:306-10.
    • (1995) Immunol Today , vol.16 , pp. 306-310
    • Robey, E.1    Allison, J.P.2
  • 15
    • 0028500255 scopus 로고
    • Absence of B7-dependent responses in CD28-deficient mice
    • Green JM, Noel PJ, Sperling AI et al. Absence of B7-dependent responses in CD28-deficient mice. Immunity 1994; 1:501-8.
    • (1994) Immunity , vol.1 , pp. 501-508
    • Green, J.M.1    Noel, P.J.2    Sperling, A.I.3
  • 16
    • 0025947446 scopus 로고
    • B-cell surface antigen B7 provides a costimulatory signal that induces T cells to proliferate and secrete interleukin 2
    • Gimmi CD, Freeman GJ, Gribben JG et al. B-cell surface antigen B7 provides a costimulatory signal that induces T cells to proliferate and secrete interleukin 2. Proc Natl Acad Sci USA 1991; 88:6575-9.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 6575-6579
    • Gimmi, C.D.1    Freeman, G.J.2    Gribben, J.G.3
  • 17
    • 0027729845 scopus 로고
    • Uncovering of functional alternative CTLA-4 counter-receptor in B7-deficient mice
    • Freeman GJ, Borriello F, Hodes RJ et al. Uncovering of functional alternative CTLA-4 counter-receptor in B7-deficient mice. Science 1993; 262:907-9.
    • (1993) Science , vol.262 , pp. 907-909
    • Freeman, G.J.1    Borriello, F.2    Hodes, R.J.3
  • 18
    • 0027403299 scopus 로고
    • The role of the CD28 receptor during T cell responses to antigen
    • Linsley PS, Ledbetter JA. The role of the CD28 receptor during T cell responses to antigen. Annu Rev Immunol 1993; 11:191-212.
    • (1993) Annu Rev Immunol , vol.11 , pp. 191-212
    • Linsley, P.S.1    Ledbetter, J.A.2
  • 19
    • 0024331402 scopus 로고
    • 1F7, a novel cell surface molecule, involved in helper function of CD4 cells
    • Morimoto C, Torimoto Y, Levinson G et al. 1F7, a novel cell surface molecule, involved in helper function of CD4 cells. J Immunol 1989; 143:3430-9.
    • (1989) J Immunol , vol.143 , pp. 3430-3439
    • Morimoto, C.1    Torimoto, Y.2    Levinson, G.3
  • 20
    • 0025325450 scopus 로고
    • Comitogenic effect of solid-phase immobilized anti-1F7 on human CD4 T cell activation via CD3 and CD2 pathways
    • Dang NH, Torimoto Y, Deusch K, Schlossman SF, Morimoto C. Comitogenic effect of solid-phase immobilized anti-1F7 on human CD4 T cell activation via CD3 and CD2 pathways. J Immunol 1990; 144:4092-100.
    • (1990) J Immunol , vol.144 , pp. 4092-4100
    • Dang, N.H.1    Torimoto, Y.2    Deusch, K.3    Schlossman, S.F.4    Morimoto, C.5
  • 21
    • 0027270023 scopus 로고
    • The costimulatory activity of the CD26 antigen requires dipeptidyl peptidase IV enzymatic activity
    • Tanaka T, Kameoka J, Yaron A, Schlossman SF, Morimoto C. The costimulatory activity of the CD26 antigen requires dipeptidyl peptidase IV enzymatic activity. Proc Natl Acad Sci USA 1993; 90:4586-90.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 4586-4590
    • Tanaka, T.1    Kameoka, J.2    Yaron, A.3    Schlossman, S.F.4    Morimoto, C.5
  • 22
    • 0021889168 scopus 로고
    • In vivo activated T lymphocytes in the peripheral blood and cerebrospinal fluid of patients with multiple sclerosis
    • Hafler DA, Fox DA, Manning ME, Schlossman SF, Reinherz EL, Weiner HL. In vivo activated T lymphocytes in the peripheral blood and cerebrospinal fluid of patients with multiple sclerosis. N Engl J Med 1985; 312:1405-11.
    • (1985) N Engl J Med , vol.312 , pp. 1405-1411
    • Hafler, D.A.1    Fox, D.A.2    Manning, M.E.3    Schlossman, S.F.4    Reinherz, E.L.5    Weiner, H.L.6
  • 23
    • 0024467949 scopus 로고
    • Increment of Tal positive cells in peripheral blood from patients with rheumatoid arthritis
    • Nakao H, Eguchi K, Kawakami A et al. Increment of Tl1 positive cells in peripheral blood from patients with rheumatoid arthritis. J Rheumatol 1989; 16:904-10.
    • (1989) J Rheumatol , vol.16 , pp. 904-910
    • Nakao, H.1    Eguchi, K.2    Kawakami, A.3
  • 24
    • 0032992914 scopus 로고    scopus 로고
    • CD26/dipeptidyl peptidase IV differentially regulates the chemotaxis of T cells and monocytes toward RANTES: Possible mechanism for the switch from innate to acquired immune response
    • Iwata S, Yamaguchi N, Munakata Y et al. CD26/dipeptidyl peptidase IV differentially regulates the chemotaxis of T cells and monocytes toward RANTES: possible mechanism for the switch from innate to acquired immune response. Int Immunol 1999; 11:417-26.
    • (1999) Int Immunol , vol.11 , pp. 417-426
    • Iwata, S.1    Yamaguchi, N.2    Munakata, Y.3
  • 25
    • 0023867161 scopus 로고
    • Current concepts: Immunology. Monocytes and macrophages
    • Johnston RB Jr. Current concepts: immunology. Monocytes and macrophages. N Engl J Med 1988; 318:747-52.
    • (1988) N Engl J Med , vol.318 , pp. 747-752
    • Johnston Jr., R.B.1
  • 26
    • 0028010859 scopus 로고
    • Comparative pharmacokinetics of the histamine H1-receptor antagonist ebastine and its active metabolite carebastine in rats, guinea pigs, dogs and monkeys
    • Matsuda M, Sakashita M, Mizuki Y, Yamaguchi T, Fujii T, Sekine Y. Comparative pharmacokinetics of the histamine H1-receptor antagonist ebastine and its active metabolite carebastine in rats, guinea pigs, dogs and monkeys. Arzneimittelforschung 1994; 44:55-9.
    • (1994) Arzneimittelforschung , vol.44 , pp. 55-59
    • Matsuda, M.1    Sakashita, M.2    Mizuki, Y.3    Yamaguchi, T.4    Fujii, T.5    Sekine, Y.6
  • 27
    • 0025172699 scopus 로고
    • The pharmacology and mechanisms of action of histamine H1-antagonists
    • Rimmer SJ, Church MK. The pharmacology and mechanisms of action of histamine H1-antagonists. Clin Exp Allergy 1990; 20(Suppl 2):3-17.
    • (1990) Clin Exp Allergy , vol.20 , Issue.2 SUPPL. , pp. 3-17
    • Rimmer, S.J.1    Church, M.K.2
  • 28
    • 0029770650 scopus 로고    scopus 로고
    • Ebastine in context. Introduction
    • Buendia E. Ebastine in context. Introduction. Drugs 1996; 52(Suppl 1):1-7.
    • (1996) Drugs , vol.52 , Issue.1 SUPPL. , pp. 1-7
    • Buendia, E.1
  • 29
    • 0029775852 scopus 로고    scopus 로고
    • Overview of allergic mechanisms. Ebastine has more than an antihistamine effect
    • Campbell A, Michel FB, Bremard-Oury C, Crampette L, Bousquet J. Overview of allergic mechanisms. Ebastine has more than an antihistamine effect. Drugs 1996; 52(Suppl 1):15-9.
    • (1996) Drugs , vol.52 , Issue.1 SUPPL. , pp. 15-19
    • Campbell, A.1    Michel, F.B.2    Bremard-Oury, C.3    Crampette, L.4    Bousquet, J.5
  • 30
    • 0035959904 scopus 로고    scopus 로고
    • Histamine regulates T-cell and antibody responses by differential expression of H1 and H2 receptors
    • Jutel M, Watanabe T, Klunker S et al. Histamine regulates T-cell and antibody responses by differential expression of H1 and H2 receptors. Nature 2001; 413:420-5.
    • (2001) Nature , vol.413 , pp. 420-425
    • Jutel, M.1    Watanabe, T.2    Klunker, S.3
  • 31
    • 0030001675 scopus 로고    scopus 로고
    • Lymphocyte homing and homeostasis
    • Butcher EC, Picker LJ. Lymphocyte homing and homeostasis. Science 1996; 272:60-6.
    • (1996) Science , vol.272 , pp. 60-66
    • Butcher, E.C.1    Picker, L.J.2
  • 32
    • 0026610142 scopus 로고
    • Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma
    • Robinson DS, Hamid Q, Ying S et al. Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma. N Engl J Med 1992; 326:298-304.
    • (1992) N Engl J Med , vol.326 , pp. 298-304
    • Robinson, D.S.1    Hamid, Q.2    Ying, S.3
  • 33
    • 0031110132 scopus 로고    scopus 로고
    • + T cells, eosinophils, and mast cells in bronchial biopsies obtained from atopic and nonatopic (intrinsic) asthmatics
    • + T cells, eosinophils, and mast cells in bronchial biopsies obtained from atopic and nonatopic (intrinsic) asthmatics. J Immunol 1997; 158:3539-44.
    • (1997) J Immunol , vol.158 , pp. 3539-3544
    • Ying, S.1    Humbert, M.2    Barkans, J.3
  • 34
    • 0032854826 scopus 로고    scopus 로고
    • Specific inhibition of TH2-type cytokine production from human peripheral T cells by terfenadine in vitro
    • Munakata Y, Umezawa Y, Iwata S et al. Specific inhibition of TH2-type cytokine production from human peripheral T cells by terfenadine in vitro. Clin Exp Allergy 1999; 29: 1281-6.
    • (1999) Clin Exp Allergy , vol.29 , pp. 1281-1286
    • Munakata, Y.1    Umezawa, Y.2    Iwata, S.3
  • 35
    • 0030011760 scopus 로고    scopus 로고
    • Cardiac actions of antihistamines
    • Woosley RL. Cardiac actions of antihistamines. Annu Rev Pharmacol Toxicol 1996; 36:233-52.
    • (1996) Annu Rev Pharmacol Toxicol , vol.36 , pp. 233-252
    • Woosley, R.L.1
  • 37
    • 0026541710 scopus 로고
    • Evidence for recent as well as long term activation of T cells migrating through endothelial cell monolayers in vitro
    • Masuyama J, Berman JS, Cruikshank WW, Morimoto C, Center DM. Evidence for recent as well as long term activation of T cells migrating through endothelial cell monolayers in vitro. J Immunol 1992; 148:1367-74.
    • (1992) J Immunol , vol.148 , pp. 1367-1374
    • Masuyama, J.1    Berman, J.S.2    Cruikshank, W.W.3    Morimoto, C.4    Center, D.M.5
  • 38
    • 0033214510 scopus 로고    scopus 로고
    • Tyrosine phosphorylation of Crk-associated substrate lymphocyte-type is a critical element in TCR- And beta 1 integrin-induced T lymphocyte migration
    • Ohashi Y, Iwata S, Kamiguchi K, Morimoto C. Tyrosine phosphorylation of Crk-associated substrate lymphocyte-type is a critical element in TCR-and beta 1 integrin-induced T lymphocyte migration. J Immunol 1999; 163:3727-34.
    • (1999) J Immunol , vol.163 , pp. 3727-3734
    • Ohashi, Y.1    Iwata, S.2    Kamiguchi, K.3    Morimoto, C.4
  • 39
    • 0035955676 scopus 로고    scopus 로고
    • The role of CD47 in neutrophil transmigration. Increased rate of migration correlates with increased cell surface expression of CD47
    • Liu Y, Merlin D, Burst SL, Pochet M, Madara JL, Parkos CA. The role of CD47 in neutrophil transmigration. Increased rate of migration correlates with increased cell surface expression of CD47. J Biol Chem 2001; 276:40156-66.
    • (2001) J Biol Chem , vol.276 , pp. 40156-40166
    • Liu, Y.1    Merlin, D.2    Burst, S.L.3    Pochet, M.4    Madara, J.L.5    Parkos, C.A.6
  • 40
    • 0031748738 scopus 로고    scopus 로고
    • Inhibition of interleukin-4 and interleukin-13 release from immunologically activated human basophils due to the actions of anti-allergic drugs
    • Gibbs BF, Vollrath IB, Albrecht C, Amon U, Wolff HH. Inhibition of interleukin-4 and interleukin-13 release from immunologically activated human basophils due to the actions of anti-allergic drugs. Naunyn Schmiedebergs Arch Pharmacol 1998; 357:573-8.
    • (1998) Naunyn Schmiedebergs Arch Pharmacol , vol.357 , pp. 573-578
    • Gibbs, B.F.1    Vollrath, I.B.2    Albrecht, C.3    Amon, U.4    Wolff, H.H.5
  • 41
    • 0023147156 scopus 로고
    • Secretory products of macrophages
    • Nathan CF. Secretory products of macrophages. J Clin Invest 1987; 79:319-26.
    • (1987) J Clin Invest , vol.79 , pp. 319-326
    • Nathan, C.F.1
  • 43
    • 0034581503 scopus 로고    scopus 로고
    • Activation of tumor necrosis factor receptor 1 in airway smooth muscle: A potential pathway that modulates bronchial hyper-responsiveness in asthma?
    • Amrani Y, Chen H, Panettieri RA Jr. Activation of tumor necrosis factor receptor 1 in airway smooth muscle: a potential pathway that modulates bronchial hyper-responsiveness in asthma? Respir Res 2000; 1:49-53.
    • (2000) Respir Res , vol.1 , pp. 49-53
    • Amrani, Y.1    Chen, H.2    Panettieri Jr., R.A.3
  • 44
    • 0031913593 scopus 로고    scopus 로고
    • Interleukin 6 and its receptor: Ten years later
    • Hirano T. Interleukin 6 and its receptor: ten years later. Int Rev Immunol 1998; 16:249-84.
    • (1998) Int Rev Immunol , vol.16 , pp. 249-284
    • Hirano, T.1
  • 45
    • 0028937777 scopus 로고
    • T cells and cytokines in bronchoalveolar lavage fluid after segmental allergen provocation in atopic asthma
    • Virchow JC Jr., Walker C, Hafner D et al. T cells and cytokines in bronchoalveolar lavage fluid after segmental allergen provocation in atopic asthma. Am J Respir Crit Care Med 1995; 151:960-8.
    • (1995) Am J Respir Crit Care Med , vol.151 , pp. 960-968
    • Virchow Jr., J.C.1    Walker, C.2    Hafner, D.3
  • 47
    • 0034189490 scopus 로고    scopus 로고
    • TNF-alpha antagonists for the treatment of Crohn's disease
    • Kam LY, Targan SR. TNF-alpha antagonists for the treatment of Crohn's disease. Expert Opin Pharmacother 2000; 1:615-22.
    • (2000) Expert Opin Pharmacother , vol.1 , pp. 615-622
    • Kam, L.Y.1    Targan, S.R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.