Rosiglitazone effects to ameliorate Alzheimer's disease pathogenic features: Insulin signaling and neurotrophic factors

Journal of Neuropsychiatry and Clinical Neurosciences

Volumn 21, Issue 3, 2009, Pages 347-348

  Castillo Quan, Jorge I ^a,b  

^a UNIVERSIDAD AUTÓNOMA DE YUCATÁN   (Mexico)

^b Hospital Regional Mérida   (Mexico)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; BRAIN DERIVED NEUROTROPHIC FACTOR; INSULIN; INSULIN RECEPTOR; NEUROTROPHIC FACTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; ROSIGLITAZONE;

ALZHEIMER DISEASE; BIPOLAR DISORDER; COGNITIVE DEFECT; HUMAN; INSULIN RESISTANCE; LETTER; MAJOR DEPRESSION; MEMORY; METABOLIC SYNDROME X; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PARKINSON DISEASE; PATHOGENESIS; PRIORITY JOURNAL; RISK FACTOR;

ALZHEIMER DISEASE; ANIMALS; BRAIN; HUMANS; INSULIN; NERVE GROWTH FACTORS; NEUROPROTECTIVE AGENTS; RATS; SIGNAL TRANSDUCTION; THIAZOLIDINEDIONES;

EID: 70349646311     PISSN: 08950172     EISSN: None     Source Type: Journal    
DOI: 10.1176/jnp.2009.21.3.347     Document Type: Letter

References (5)

1. Elliott E, Ginzburg I: The role of neurotrophins and insulin on tau pathology in Alzheimer's disease. Rev Neurosci 2006; 17:635-642 (Pubitemid 46144733)
2. Clodfelder-Miller BJ, Zmijewska AA, Johnson GV, et al: Tau is hyperphosphorylated at multiple sites in mouse brain in vivo after streptozotocin-induced insulin deficiency. Diabetes 2006; 55:3320-3325
3. Zhao L, Teter B, Morihara T, et al: Insulin-degrading enzyme as a downstream target of insulin receptor signaling cascade: implications for Alzheimer's disease intervention. J Neurosci 2004; 24:11120-11126 (Pubitemid 40012971)
4. Fuenzalida KM, Aguilera MC, Piderit DG, et al: Peroxisome proliferator-activated receptor gamma is a novel target of the nerve growth factor signaling pathway in PC12 cells. J Biol Chem 2005; 280:9604-9609
5. Reger MA, Watson GS, Green PS, et al: Intranasal insulin improves cognition and modulates beta-amyloid in early AD. Neurology 2008; 70:440-448