Obesity and hypertension, heart failure, and coronary heart disease - Risk factor, paradox, and recommendations for weight loss

Ochsner Journal

Volumn 9, Issue 3, 2009, Pages 124-132

  Artham, Surya M ^a   Lavie, Carl J ^a   Milani, Richard V ^a   Ventura, Hector O ^a  

^a OCHSNER CLINIC FOUNDATION   (United States)

Author keywords

Coronary heart disease; Heart failure; Hypertension; Obesity; Obesity paradox; Weight loss

Indexed keywords

ADVERSE OUTCOME; CARDIOVASCULAR RISK; DIABETES MELLITUS; DISEASE ASSOCIATION; DYSLIPIDEMIA; HEART ARRHYTHMIA; HEART FAILURE; HEART FUNCTION; HUMAN; HYPERTENSION; ISCHEMIC HEART DISEASE; NEOPLASM; OBESITY; PREVALENCE; PROGNOSIS; REVIEW; RISK FACTOR; WEIGHT REDUCTION;

EID: 70349643105     PISSN: 15245012     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (78)

1. Poirier P, Giles TD, Bray GA, et al. Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss: an update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease from the Obesity Committee of the Council on Nutrition, Physical activity, and Metabolism. Circulation. 2006;113:898-918.
2. Artham SM, Lavie CJ, Milani RV, Ventura HO. The obesity paradox: impact of obesity on the prevalence and prognosis of cardiovascular diseases. Postgrad Med. 2008;120:34-41.
3. Klein S, Burke LE, Bray GA, et al. Clinical implications of obesity with specific focus on cardiovascular disease: a statement for professionals from the American Heart Association Council on Nutrition, Physical Activity, and Metabolism: endorsed by the American College of Cardiology Foundation. Circulation. 2004;110:2952-2967.
4. Flegal KM, Carroll MD, Ogden CL, Johnson CL. Prevalence and trends in obesity among US adults, 1999-2000. JAMA. 2002;288:1723-1727.
5. Lavie CJ, Milani RV, Ventura HO. Obesity and cardiovascular disease: risk factor, paradox, and impact of weight loss. J Am Coll Cardiol. 2009;53:1925-1932.
6. Lavie CJ, Milani RV. Obesity and cardiovascular disease: the Hippocrates paradox? J Am Coll Cardiol. 2003;42:677-679.
7. Sturm R, Well KB. Does obesity contribute as much to morbidity as poverty or smoking? Public Health. 2001;115:229-235.
8. Mokdad AH, Serdula MK, Dietz WH, Bowman BA, Marks JS, Koplan JP. The spread of the obesity epidemic in the United States, 1991- 1998. JAMA. 1999;282:1519-1522.
9. US Department of Health and Human Services. The Surgeon General's Call to Action to Prevent and Decrease Overweight and Obesity. Rockville, MD: US Department of Health and Human Services, Public Health Service, Office of the Surgeon General; 2001.
10. Kenchaiah S, Evans JC, Levy D, et al. Obesity and the risk of heart failure. N Engl J Med. 2002;347:305-313.
11. Lavie CJ, Milani RV, Ventura HO. Untangling the heavy cardiovascular burden of obesity. Nat Clin Pract Cardiovasc Med. 2008;5:428-429.
12. Lavie CJ, Milani RV, Ventura HO, Cardenas GA, Mehra MR, Messerli FH. Disparate effects of left ventricular geometry and obesity on mortality in patients with preserved left ventricular ejection fraction. Am J Cardiol. 2007;100:1460-1464. (Pubitemid 47576028)
13. Lavie CJ, Milani RV, Ventura HO. Obesity, heart disease, and favorable prognosis - truth or paradox? Am J Med. 2007;120:825-826.
14. Artham SM, Lavie CJ, Patel HM, Ventura HO. Impact of obesity on the risk of heart failure and its prognosis. J Cardiometab Syndr. 2008;3:155-161.
15. Olshansky SJ, Passaro DJ, Hershow RC, et al. A potential decline in life expectancy in the United States in the 21st century. N Engl J Med. 2005;352:1138-1145. (Pubitemid 40365358)
16. Himes JH, Bouchard C. Do the new Metropolitan Life Insurance weight-height tables correctly assess body frame and body fat relationships? Am J Public Health. 1985;75:1076-1079.
17. Litwin SE. Which measures of obesity best predict cardiovascular risk? J Am Coll Cardiol. 2008;52:616-619.
18. Gottdiener JS, Reda DJ, Materson BJ. Importance of obesity, race and age to the cardiac structural and functional effects of hypertension: the Department of Veterans Affairs Cooperative Study Group on Antihypertensive Agents. J Am Coll Cardiol. 1994;24:1492-1498.
19. Rahmouni K, Correia ML, Haynes WG, et al. Obesity-associated hypertension: new insights into mechanisms. Hypertension. 2004;45:9-14.
20. Lavie CJ, Messerli FH. Cardiovascular adaptation to obesity and hypertension. Chest. 1986;90:275-279.
21. Lavie CJ, Milani RV, Messerli FH. From obesity, hypertension, and left ventricular hypertrophy to heart failure. Ochsner J. 2000;2(suppl):s8-s14.
22. Messerli FH, Sundgaard-Riise K, Reisin ED, et al. Dimorphic cardiac adaptation to obesity and arterial hypertension. Ann Intern Med. 1983;99:757-761.
23. Messerli FH. Cardiovascular effects of obesity and hypertension. Lancet. 1982;1:1165-1168.
24. Lavie CJ, Ventura HO, Messerli FH. Left ventricular hypertrophy: its relationship to obesity and hypertension. Postgrad Med. 1992;91:131-143.
25. Milani RV, Lavie CJ, Mehra MR, Ventura HO, Kurtz JD, Messerli FH. Left ventricular geometry and survival in patients with normal left ventricular ejection fraction. Am J Cardiol. 2006;97:959-963.
26. Lavie CJ, Milani RV, Shah SB, et al. Impact of left ventricular geometry on prognosis - a review of Ochsner studies. Ochsner J. 2008;8:11-17.
27. National Institutes of Health. Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults: the evidence report. Obes Res. 1998;suppl 2:51S-209S.
28. Brown CD, Higgins M, Donato KA, et al. Body mass index and the prevalence of hypertension and dyslipidemia. Obes Res. 2000;8:605-619.
29. Wilhelmsen L, Rosengren A, Eriksson H, Lappas G. Heart failure in the general population of men: morbidity, risk factors and prognosis. J Intern Med. 2001;249:253-261. (Pubitemid 32417788)
30. Alpert MA, Terry BE, Mulekar M, et al. Cardiac morphology and left ventricular function in normotensive morbidly obese patients with and without congestive heart failure, and effect of weight loss. Am J Cardiol. 1997;80:736-740. (Pubitemid 27413582)
31. Lavie CJ, Amodeo C, Ventura HO, et al. Left atrial abnormalities indicating diastolic ventricular dysfunction in cardiopathy of obesity. Chest. 1987;92:1042-1046. (Pubitemid 18026544)
32. Alpert MA, Lambert CR, Panayiotou H, et al. Relation of duration of morbid obesity to left ventricular mass, systolic function, and diastolic filling, and effect of weight loss. Am J Cardiol. 1995;76:1194-1197.
33. Jousilahti P, Tuomilehto J, Vartiainen E, et al. Body weight, cardiovascular risk factors, and coronary mortality: 15-year followup of middle-aged men and women in eastern Finland. Circulation. 1996;93:1372-1379. (Pubitemid 126425256)
34. Miller MT, Lavie CJ, White CJ. Impact of obesity on the pathogenesis and prognosis of coronary heart disease. J Cardiometab Syndr. 2008;3:162-167.
35. McGill HC Jr, McMahan CA, Herderick EE. et al; Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group. Obesity accelerates the progression of coronary atherosclerosis in young men. Circulation. 2002;105:2712-2718.
36. McMahan CA, McGill HC, Gidding SS. et al; Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group. PDAY risk score predicts advanced coronary artery atherosclerosis in middle-aged persons as well as youth. Atherosclerosis. 2007;190:370-377.
37. Rabkin SW, Mathewson FA, Hsu PH. Relation of body weight to development of ischemic heart disease in a cohort of young North American men after a 26 year observation period: the Manitoba Study. Am J Cardiol. 1977;39:452-458.
38. Hubert HB, Feinleib M, McNamara PM, Castelli WP. Obesity as an independent risk factor for cardiovascular disease: a 26-year follow-up of participants in the Framingham Heart Study. Circulation. 1983;67:968-977.
39. Manson JE, Colditz GA, Stampfer MJ, et al. A prospective study of obesity and risk of coronary heart disease in women. N Engl J Med. 1990;322:882-889. (Pubitemid 20108377)
40. Festa A, D'Agostine R Jr, Williams K, et al. The relation of body fat mass and distribution to markers of chronic inflammation. Int J Obes Relat Metab Disord. 2001;25:1407-1415. (Pubitemid 32977855)
41. Traupe T, Lang M, Goettsch W, et al. Obesity increases prostanoidmediated vasoconstriction and vascular thromboxane receptor gene expression. J Hypertens. 2002;20:2239-2245. (Pubitemid 35388243)
42. Lavie CJ, Milani RV, Artham SM, et al. Does body composition impact survival in patients with advanced heart failure. Circulation. 2007;116(16 suppl II):360.
43. Horwich TB, Fonarow GC, Hamilton MA, et al. The relationship between obesity and mortality in patients with heart failure. J Am Coll Cardiol. 2001;38:789-795. (Pubitemid 32835754)
44. Lavie CJ, Osman AF, Milani RV. Body composition and prognosis in chronic systolic heart failure: the obesity paradox. Am J Cardiol. 2003;91:891-894. (Pubitemid 36363743)
45. Lavie CJ, Mehra MR, Milani RV. Obesity and heart failure prognosis: paradox or reverse epidemiology? Eur Heart J. 2005;26:5-7.
46. Curtis JP, Selter JG, Wang Y, et al. The obesity paradox: body mass index and outcomes in patients with heart failure. Arch Intern Med. 2005;165:55-61. (Pubitemid 40096082)
47. Artham SM, Lavie CJ, Milani RV, et al. The obesity paradox and discrepancy between peak oxygen consumption and heart failure prognosis - it's all in the fat. Congest Heart Fail. 2007;13:177-180.
48. Lavie CJ, Milani RV, Mehra MR. Obesity, weight reduction and survival in heart failure. J Am Coll Cardiol. 2002;39:1563.
49. Artham SM, Ventura HO. The "obesity paradox" and heart failure: the story continues. Rev Esp Cardiol. 2007;60: 1113-1117. (Pubitemid 350294339)
50. Lavie CJ, Milani RV, Artham SM. Combating the obesity paradox - benefits and safety of purposeful weight loss in overweight and obese coronary patients. J Am Coll Cardiol. 2008;5(10 suppl A): A107.
51. Romero-Corral A, Montori VM, Somers VK, et al. Association of bodyweight with total mortality and with cardiovascular events in coronary artery disease: a systematic review of cohort studies. Lancet. 2006;368:666-678. (Pubitemid 44223694)
52. Ottervanger JP, Armstrong P, Barnathan ES, et al. Long-term results after the glycoprotein IIb/IIIa inhibitor abciximab in unstable angina: one-year survival in the GUSTO IV-ACS (Global Use of Strategies To Open Occluded Coronary Arteries IV - Acute Coronary Syndrome) Trial. Circulation. 2003;107:437-442. (Pubitemid 36158046)
53. Buettner HJ, Mueller C, Gick M, et al. The impact of obesity on mortality in UA/non-ST-segment elevation myocardial infarction. Eur Heart J. 2007;28:1694-1701. (Pubitemid 47227103)
54. Gurm HS, Whitlow PL, Kip KE; BARI Investigators. The impact of body mass index on short- and long-term outcomes in patients undergoing coronary revascularization: insights from the bypass angioplasty revascularization investigation (BARI). J Am Coll Cardiol. 2002;39:834-840.
55. Gruberg L, Weissman NJ, Waksman R, et al. The impact of obesity on the short-term and long-term outcomes after percutaneous coronary intervention: the obesity paradox? J Am Coll Cardiol. 2002;39:578-584. (Pubitemid 34158151)
56. Minutello RM, Chou ET, Hong MK, et al. Impact of body mass index on in-hospital outcomes following percutaneous coronary intervention (report from the New York State Angioplasty Registry). Am J Cardiol. 2004;93:1229-1232. (Pubitemid 38595675)
57. Uretsky S, Messerli FH, Bangalore S, et al. Obesity paradox in hypertension and coronary artery disease. Am J Med. 2007;120:863-870. (Pubitemid 47451305)
58. Wassertheil-Smoller S, Fann C, Allman RM. et al; for the SHEP Cooperative Research Group. Relation of low body mass to death and stroke in the systolic hypertension in the elderly program. Arch Intern Med. 2000;160:494-500.
59. Stamler RO, Ford CE, Stamler J. Why do lean hypertensives have higher mortality rates than other hypertensives: findings of the Hypertension Detection and Follow-up Program. Hypertension. 1991;17:553-564.
60. Tuomilehto J. Body mass index and prognosis in elderly hypertensive patients: a report from the European Working Party on High Blood Pressure in the Elderly. Am J Med. 1991;90:S34-S41.
61. Lavie CJ, Milani RV, Patel D, Artham SM. Disparate effects of obesity and left ventricular geometry on mortality in 8088 elderly with preserved systolic function. J Am Coll Cardiol. 2008;51:A107.
62. Mehra MR, Uber PA, Parh MH, et al. Obesity and suppressed B-type natriuretic peptide levels in heart failure. J Am Coll Cardiol. 2004;43:1590-1595. (Pubitemid 38561338)
63. Oreopoulos A, Padwal R, Kalantar-Zadeh K, et al. Body mass index and mortality in heart failure: a meta-analysis. Am Heart J. 2008;156:13-22. (Pubitemid 351862293)
64. Kalantar-Zadeh K, Block G, Horwich T, Fonarow GC. Reverse epidemiology of conventional cardiovascular risk factors in patients with chronic heart failure. J Am Coll Cardiol. 2004;43:1439-1444. (Pubitemid 38496352)
65. Anker S, Rauchhaus M. Insights into the pathogenesis of chronic heart failure: immune activation and cachexia. Curr Opin Cardiol. 1999;14:211-216. (Pubitemid 29199657)
66. Anker S, Negassa A, Coats AJ, et al. Prognostic importance of weight loss in chronic heart failure and the effect of treatment with angiotensin- converting enzyme inhibitors: an observational study. Lancet. 2003;361:1077-1083. (Pubitemid 36369559)
67. Mohamed-Ali V, Goodrick S, Bulmer K, et al. Production of soluble tumor necrosis factor receptors by human subcutaneous adipose tissue in vivo. Am J Physiol. 1999;277:E971-E975. (Pubitemid 30045988)
68. Schrier R, Abraham WT. Hormones and hemodynamics in heart failure. N Eng J Med. 1999;341:577-585.
69. Weber M, Neutel JM, Smith DHG. Contrasting clinical properties and exercise responses in obese and lean hypertensive patients. J Am Coll Cardiol. 2001;37:169-174. (Pubitemid 32051734)
70. Lavie CJ, Ventura HO, Milani RV. The "obesity paradox": is smoking/lung disease the explanation? Chest. 2008;134:896-898.
71. MacMahon S, Collins G, Rautaharju P, et al. Electrocardiographic left ventricular hypertrophy and effects of antihypertensive drug therapy in hypertensive participants in the Multiple Risk Factor Intervention Trial. Am J Cardiol. 1989;63:202-210. (Pubitemid 19032807)
72. Milani RV, Lavie CJ. Prevalence and profile of metabolic syndrome in patients following acute coronary events and effects of therapeutic lifestyle change with cardiac rehabilitation. Am J Cardiol. 2003;92:50-54.
73. Lavie CJ, Milani RV. Effects of cardiac rehabilitation, exercise training, and weight reduction on exercise capacity, coronary risk factors, behavioral characteristics, and quality of life in obese coronary patients. Am J Cardiol. 1997;79:397-401. (Pubitemid 127440400)
74. Lavie CJ, Morshedi-Meibodi A, Milani RV. Impact of cardiac rehabilitation on coronary risk factors, inflammation, and the metabolic syndrome in obese coronary patients. J Cardiometab Syndr. 2008;3:136-140.
75. Adams TD, Gress RE, Smith SC, et al. Long-term mortality after gastric bypass surgery. N Engl J Med. 2007;357:753-761. (Pubitemid 47295642)
76. Sjöström L, Narbro K, Sjöström CD, et al. Effects of bariatric surgery on mortality in Swedish obese subjects. N Engl J Med. 2007;357:741-752. (Pubitemid 47295641)
77. Batsis JA, Romero-Corral A, Collazo-Claveli ML. Effect of bariatric surgery on the metabolic syndrome: a population-based, long-term controlled study. Mayo Clin Proc. 2008;83:897-906.
78. Ramani GV, McCloskey C, Ramanathan RC, Mathier MA. Safety and efficacy of bariatric surgery in morbidly obese patients with severe systolic heart failure. Clin Cardiol. 2008;31: 516-520.