Untangling the heavy cardiovascular burden of obesity

Nature Clinical Practice Cardiovascular Medicine

Volumn 5, Issue 7, 2008, Pages 428-429

  Lavie, Carl J ^a   Milani, Richard V ^a   Ventura, Hector O ^a  

^a OCHSNER CLINIC FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LEPTIN;

ACUTE HEART INFARCTION; ADRENERGIC SYSTEM; APOPTOSIS; ARTICLE; ATHEROSCLEROSIS; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CONCENTRATION (PARAMETERS); CORRELATION ANALYSIS; ENERGY METABOLISM; EXERCISE TOLERANCE; FOOD INTAKE; HEART DISEASE; HEART HYPERTROPHY; HEART MUSCLE CONTRACTILITY; HIGH RISK PATIENT; HUMAN; HYPERTENSION; LEAN BODY WEIGHT; METABOLIC DISORDER; OBESITY; PATHOGENESIS; PHYSICAL ACTIVITY; PREDICTION; PRESSORECEPTOR; PRIMARY PREVENTION; PRIORITY JOURNAL; PROTEIN SYNTHESIS; REPERFUSION INJURY; WEIGHT REDUCTION;

C-REACTIVE PROTEIN; CARDIOVASCULAR DISEASES; EXERCISE; HUMANS; LEPTIN; OBESITY; PRESSORECEPTORS; RISK FACTORS; SYMPATHETIC NERVOUS SYSTEM;

EID: 46649085646     PISSN: 17434297     EISSN: 17434300     Source Type: Journal    
DOI: 10.1038/ncpcardio1257     Document Type: Article

References (13)

1. Lavie CJ et al. (2007) Obesity, heart disease, and favorable prognosis - truth or paradox? Am J Med 120: 825-826
2. Ross R (1999) Atherosclerosis - an inflammatory disease. N Engi J Med 340: 115-126
3. Zwaka TP et al. (2001) C-reactive protein-medicated low density lipoprotein uptake by macrophages: Implications for atherosclerosis. Circulation 103: 1194-1197
4. Milani RV et al. (2004) Reduction in C-reactive protein through cardiac rehabilitation and exercise training. J Am Coll Cardlol 43: 1056-1061
5. Romero-Corral et al. (2008) Relationships between leptin and C-reactive protein with cardiovascular disease in the adult general population. Nat Clin Pract Cardiovasc Med 5: 418-425
6. Unger RH and Elmquist JK (2006) Movin'on up: Adipocytes become regulators of nutrient homeostasis. Cell Metab 3: 147-148
7. Chen K et al. (2006) Induction of leptin resistance through direct interaction of C-reactive protein with leptin. Nat Med 12: 425-432
8. Ridker PM et al.; Pravastatin or atorvastatin evaluation and infection therapy-thrombolysis in myocardial infarction 22 (PROVE IT-TIMI 22) Investigators (2005). C-reactive protein levels and outcomes after statin therapy. N Engl J Med 352: 20-28
9. Yang R and Barouch LA (2007) Leptin signaling and obesity: cardiovascular consequences. Circ Res 101: 545-559
10. Esler M et al. (2006) Mechanisms of sympathetic activation in obesity-related hypertension. Hypertension 48: 787-796
11. Grassi G and Elam M (2002) Leptin, sympathetic and baroreflex function: another step on the road to sympathetic differentiation. J Hypertens 20: 1487-1489
12. Gertler A (2006) Development of leptin antagonists and their potential use in experimental biology and medicine. Trends Endocrinol Metab 17: 372-378
13. Blair SN and Church TS (2004) The fitness, obesity, and health equation. Is physical activity the common denominator? JAMA 292: 1232-1234