Deletion of one SERCA2 allele confers protection against bladder wall hypertrophy in a murine model of partial bladder outlet obstruction

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 294, Issue 1, 2008, Pages

  Lassmann, Jenny ^a   Sliwoski, Joanna ^a   Chang, Andy ^a   Canning, Douglas A ^a   Zderic, Stephen A ^a  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

Nuclear factor of activated T cells; Obstruction; Sarco(endo)plasmic reticulum Ca 2+ ATPase2; Urinary bladder

Indexed keywords

BROXURIDINE; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE;

ANIMAL MODEL; ARTICLE; BLADDER NECK STENOSIS; BODY MASS; CELL PROLIFERATION; CYSTOMETRY; GEL MOBILITY SHIFT ASSAY; GENE DELETION; GENE TRANSLOCATION; IN VITRO STUDY; KIDNEY HYPERTROPHY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTECTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SYNTHESIS;

ALLELES; ANIMALS; CALCIUM SIGNALING; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; GENE DELETION; GENOTYPE; HYPERTROPHY; MALE; MICE; MICE, MUTANT STRAINS; MUSCLE, SMOOTH; MYOSIN HEAVY CHAINS; NFATC TRANSCRIPTION FACTORS; PHENOTYPE; PROTEIN ISOFORMS; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; URINARY BLADDER; URINARY BLADDER NECK OBSTRUCTION;

EID: 38149073092     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00477.2007     Document Type: Article

References (35)

1. 2+-ATPase mRNA isoform, SERCA 3, is expressed in endothelial and epithelial cells in various organs. FEBS Lett 334: 45-48, 1993.
2. 2+ homeostasis in pancreatic β-cells. Diabetes 51: 3245-3253, 2002.
3. Austin JC, Chacko SK, DiSanto M, Canning DA, Zderic SA. A male murine model of partial bladder outlet obstruction reveals changes in detrusor morphology, contractility and myosin isoform expression. J Urol 172: 1524-1528, 2004.
4. Babu GJ, Loukianov E, Loukianova T, Pyne GJ, Huke S, Osol G, Low RB, Paul RJ, Periasamy M. Loss of SM-B myosin affects muscle shortening velocity and maximal force development. Nat Cell Biol 3: 1025-1029, 2001.
5. 2+ ATPase genes: homologies and mechanistic implications of deduced amino acid sequences. Cell 44: 597-607, 1986.
6. 2+ pump. J Biol Chem 264: 18561-18568, 1989.
7. Cheung WM, D'Andrea MR, Andrade-Gordon P, Damiano BP. Altered vascular injury responses in mice deficient in protease-activated receptor-1. Arterioscler Thromb Vasc Biol 19: 3014-3024, 1999.
8. Chien KR. The Molecular Basis of Cardiovascular Disease. Philadelphia, PA: Saunders, 2004.
9. Clement M, Delaney DP, Austin JC, Sliwoski J, Hii GC, Canning DA, DiSanto ME, Chacko SK, Zderic SA. Activation of the calcineurin pathway is associated with detrusor decompensation: a potential therapeutic target. J Urol: 1225-1229, 2006.
10. Crabtree GR, Olson EN. NFAT signaling: choreographing the social lives of cells. Cell 109, Suppl: S67-S79, 2002.
11. 2+-ATPase 2 isoform (SERCA2c). Biochem J 395: 249-258, 2006.
12. DiSanto ME, Stein R, Chang S, Hypolite JA, Zheng Y, Zderic S, Wein AJ, Chacko S. Alteration in expression of myosin isoforms in detrusor smooth muscle following bladder outlet obstruction. Am J Physiol Cell Physiol 285: C1397-C1410, 2003.
13. DiSanto ME, Stein R, Chang S, Hypolite JA, Zheng Y, Zderic S, Wein AJ, Chacko S. Alteration in expression of myosin isoforms in detrusor smooth muscle following bladder outlet obstruction. Am J Physiol Cell Physiol 285: C1397-C1410, 2003.
14. 2+-ATPase 3 gene. Promoter analysis and alternative splicing of the SERCA3 pre-mRNA. J Biol Chem 273: 13982-13994, 1998.
15. 2+ and other cation-transporting ATPases using an oligonucleotide probe derived from the ATP-binding site. J Biol Chem 263: 15032-15040, 1988.
16. Hutcheson JC, Stein R, Canning DA, Wein AJ, Chacko SK, Zderic SA. Murine in vitro whole bladder physiology. Adv Exp Med Biol 539: 337-345, 2003.
17. Kelley CA, Takahashi M, Yu JH, Adelstein RS. An insert of seven amino acids confers functional differences between smooth muscle myosins from the intestines and vasculature. J Biol Chem 268: 12848-12854, 1993.
18. Levin RM, Haugaard N, Mogavero L, Leggett RE, Das AK. Biochemical evaluation of obstructive bladder dysfunction in men secondary to BPH: a preliminary report. Urology 53: 446-450, 1999.
19. 2+-dependent ATPase from rabbit muscle sarcoplasmic reticulum, deduced from its complementary DNA sequence. Nature 316: 696-700, 1985.
20. Molkentin JD, Lu JR, Antos CL, Markham B, Richardson J, Robbins J, Grant SR, Olson EN. A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Cell 93: 215-228, 1998.
21. Monson FC, McKenna BA, Wein AJ, Levin RM. Effect of outlet obstruction on 3H-thymidine uptake: a biochemical and radioautographic study. J Urol 148: 158-162, 1992.
22. Monson FC, Sun L, Wein AJ, Levin RM. Hyperplasia in the rabbit bladder urothelium following partial outlet obstruction. Autoradiographic evidence. Mol Cell Biochem 152: 167-173, 1995.
23. Nozaki K, Tomizawa K, Yokoyama T, Kumon H, Matsui H. Calcineurin mediates bladder smooth muscle hypertrophy after bladder outlet obstruction. J Urol 170: 2077-2081, 2003.
24. 2+ ATPase, are associated with Brody disease. Nat Genet 14: 191-194, 1996.
25. 2+-ATPase isoform 2 (SERCA2) gene. J Biol Chem 274: 2556-2562, 1999.
26. Prasad V, Okunade GW, Miller ML, Shull GE. Phenotypes of SERCA and PMCA knockout mice. Biochem Biophys Res Commun 322: 1192-1203, 2004.
27. Schultz Jel J, Glascock BJ, Witt SA, Nieman ML, Nattamai KJ, Liu LH, Lorenz JN, Shull GE, Kimball TR, Periasamy M. Accelerated onset of heart failure in mice during pressure overload with chronically decreased SERCA2 calcium pump activity. Am J Physiol Heart Circ Physiol 286: H1146-H1153, 2004.
28. Sjuve R, Haase H, Ekblad E, Malmqvist U, Morano I, Arner A. Increased expression of non-muscle myosin heavy chain-B in connective tissue cells of hypertrophic rat urinary bladder. Cell Tissue Res 304: 271-278, 2001.
29. Stein R, Gong C, Hutcheson J, Krasnopolsky L, Canning DA, Carr M, Zderic SA. The fate of urinary bladder smooth muscle after outlet obstruction-a role for the sarcoplasmic reticulum. Adv Exp Med Biol 539: 773-790, 2003.
30. Stein R, Gong C, Hutcheson JC, Canning DA, Zderic SA. The decompensated detrusor III: impact of bladder outlet obstruction on sarcoplasmic endoplasmic reticulum protein and gene expression. J Urol 164: 1026-1030, 2000.
31. Wankerl M, Schwartz K. Calcium transport proteins in the nonfailing and failing heart: gene expression and function. J Mol Med 73: 487-496, 1995.
32. White S, Martin AF, Periasamy M. Identification of a novel smooth muscle myosin heavy chain cDNA: isoform diversity in the S1 head region. Am J Physiol Cell Physiol 264: C1252-C1258, 1993.
33. Wilkins BJ, Molkentin JD. Calcium-calcineurin signaling in the regulation of cardiac hypertrophy. Biochem Biophys Res Commun 322: 1178-1191, 2004.
34. Wilkins BJ, Molkentin JD. Calcium-calcineurin signaling in the regulation of cardiac hypertrophy. Biochem Biophys Res Commun 322: 1178-1191, 2004.
35. Zderic SA, Rohrmann D, Gong C, Snyder HM, Duckett JW, Wein AJ, Levin RM. The decompensated detrusor II: evidence for loss of sarcoplasmic reticulum function after bladder outlet obstruction in the rabbit. J Urol 156: 587-592, 1996.