An orally effective dihydropyrimidone (DHPM) analogue induces apoptosis-like cell death in clinical isolates of Leishmania donovani overexpressing pteridine reductase 1

Parasitology Research

Volumn 105, Issue 5, 2009, Pages 1317-1325

  Singh, Neeloo ^a   Kaur, Jaspreet ^a   Kumar, Pranav ^a   Gupta, Swati ^a   Singh, Nasib ^a   Ghosal, Angana ^b   Dutta, Avijit ^b   Kumar, Ashutosh ^a   Tripathi, Ramapati ^a   Siddiqi, Mohammad Imran ^a   Mandal, Chitra ^b   Dube, Anuradha ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

^b INDIAN INSTITUTE OF CHEMICAL BIOLOGY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

[(4 FLUORO PHENYL) 6 METHYL 2 THIOXO 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXYLIC ACID ETHYL ESTER]; ANTILEISHMANIAL AGENT; GREEN FLUORESCENT PROTEIN; LIPOCORTIN 5; PROPIDIUM IODIDE; PROTOZOAL DNA; PROTOZOAL PROTEIN; PTERIDINE DERIVATIVE; PTERIDINE REDUCTASE 1; PYRIMIDINONE DERIVATIVE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIPROTOZOAL ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG CYTOTOXICITY; DRUG DOSE COMPARISON; DRUG PENETRATION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME SPECIFICITY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LEISHMANIA DONOVANI; LEISHMANIASIS; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANNEXIN A5; ANTIPROTOZOAL AGENTS; APOPTOSIS; CELL DEATH; CELL SURVIVAL; CRICETINAE; DNA FRAGMENTATION; DRUG EVALUATION, PRECLINICAL; INDICATORS AND REAGENTS; LEISHMANIA DONOVANI; LEISHMANIASIS, VISCERAL; MEMBRANE POTENTIAL, MITOCHONDRIAL; OXIDOREDUCTASES; PROPIDIUM; PYRIMIDINONES; STRUCTURE-ACTIVITY RELATIONSHIP;

LEISHMANIA DONOVANI; PROTOZOA;

EID: 70349595087     PISSN: 09320113     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00436-009-1557-z     Document Type: Article

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