Prediction of hepatic microsomal intrinsic clearance and human clearance values for drugs

Journal of Molecular Graphics and Modelling

Volumn 28, Issue 3, 2009, Pages 245-252

  Nikolic, Katarina ^a   Agababa, Danica ^a  

^a UNIVERSITY OF BELGRADE   (Serbia)

Author keywords

Cytochrome P450 enzyme; Drug metabolism; Hepatic clearance; Human clearance; QSAR

Indexed keywords

CYTOCHROME P450 ENZYME; DRUG METABOLISM; HEPATIC CLEARANCE; HUMAN CLEARANCE; QSAR;

BIOCHEMISTRY; ENZYMES; METABOLISM; MOLECULAR GRAPHICS; SULFUR COMPOUNDS;

BLOOD;

ALPRAZOLAM; AMITRIPTYLINE; AMOBARBITAL; CHLORPROMAZINE; CLOZAPINE; CYTOCHROME P450; DESIPRAMINE; DEXAMETHASONE; DIAZEPAM; DICLOFENAC; DILTIAZEM; DIPHENHYDRAMINE; HEXOBARBITAL; IBUPROFEN; IMIPRAMINE; KETAMINE; LORCAINIDE; METHOHEXITAL; METHOXSALEN; MIDAZOLAM; PREDNISONE; PROPAFENONE; QUINIDINE; TENIDAP; TENOXICAM; TOLBUTAMIDE; TRIAZOLAM; VERAPAMIL; WARFARIN; ZOLPIDEM;

ARTICLE; COMPUTER PROGRAM; DRUG CLEARANCE; DRUG METABOLISM; DRUG STRUCTURE; LIVER CLEARANCE; LIVER MICROSOME; MATHEMATICAL MODEL; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

HUMANS; MICROSOMES, LIVER; MODELS, THEORETICAL; PHARMACEUTICAL PREPARATIONS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; REGRESSION ANALYSIS;

EID: 70349584738     PISSN: 10933263     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmgm.2009.08.002     Document Type: Article

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