Development of a dual modality imaging system: A combined gamma camera and optical imager

Physics in Medicine and Biology

Volumn 54, Issue 14, 2009, Pages 4547-4559

  Jung, Jin Ho ^a   Choi, Yong ^a   Hong, Key Jo ^a   Min, Byung Jun ^a   Choi, Joon Young ^a   Choe, Yearn Seong ^a   Lee, Kyung Han ^a   Kim, Byung Tae ^a  

^a Sungkyunkwan University School of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ARRAY-TYPE; BIOLOGICAL PROCESS; DUAL MODALITY; DUAL-MODALITY IMAGING; ENERGY RESOLUTIONS; EXPERIMENTAL ANIMALS; GAMMA CAMERAS; GAMMA PULSE; GAMMA SIGNALS; GAMMA-RAY IMAGING; GREEN LEDS; IMAGERS; IMAGING CAPABILITIES; MOUSE PHANTOMS; OPTICAL IMAGE; OPTICAL IMAGING; OPTICAL PHOTONS; PARALLEL HOLE COLLIMATORS; PLANAR IMAGES; POSITION SENSITIVE PHOTOMULTIPLIER TUBE; PULSE HEIGHT SPECTRUM; SPATIAL RESOLUTION; TOP SURFACE;

ANIMALS; CAMERAS; DETECTORS; ELECTROMAGNETIC WAVES; GAMMA RAYS; GEOMETRICAL OPTICS; IMAGE RESOLUTION; IMAGE SENSORS; PHOTOMULTIPLIERS; PHOTONS; POSITRON EMISSION TOMOGRAPHY; SIGNAL DETECTION; SIGNAL INTERFERENCE; STARS; TECHNETIUM; X RAY CAMERAS;

OPTICAL COLLIMATORS;

TECHNETIUM 99M;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; GAMMA RADIATION; IMAGING SYSTEM; MOUSE; NONHUMAN; PRIORITY JOURNAL; SCINTILLATION CAMERA; SENSITIVITY ANALYSIS; SIGNAL DETECTION; SIGNAL NOISE RATIO; SPATIAL FREQUENCY DISCRIMINATION; COMPUTER AIDED DESIGN; EQUIPMENT; EQUIPMENT DESIGN; IMAGE ENHANCEMENT; IMAGE SUBTRACTION; INSTRUMENTATION; OPTICAL TOMOGRAPHY; REPRODUCIBILITY; SCINTISCANNING; SENSITIVITY AND SPECIFICITY; SYSTEM ANALYSIS;

COMPUTER-AIDED DESIGN; EQUIPMENT DESIGN; EQUIPMENT FAILURE ANALYSIS; GAMMA CAMERAS; IMAGE ENHANCEMENT; RADIONUCLIDE IMAGING; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SUBTRACTION TECHNIQUE; SYSTEMS INTEGRATION; TOMOGRAPHY, OPTICAL;

EID: 70349580487     PISSN: 00319155     EISSN: 13616560     Source Type: Journal    
DOI: 10.1088/0031-9155/54/14/011     Document Type: Article

References (30)

1. Andersson-Engels S, Klinteberg C, Svanberg K and Svanberg S 1997 In vivo fluorescence imaging for tissue diagnostics Phys. Med. Biol. 42 815-24
2. Autiero M, Celentano L, Cozzolino R, Laccetti P, Marotta M, Mettivier G, Montesi M C, Riccio P, Roberti G and Russo P 2005 Experimental study on in vivo optical and radionuclide imaging in small animals IEEE Trans. Nucl. Sci. 52 205-9
3. Beuthan J, Mahnke C, Netz U, Minet O and Müller G 2002 Optical molecular imaging: overview and technological aspects Med. Laser Appl. 17 25-30
4. Beyer T, Townsend D W, Brun T, Kinahan P E, Charron M, Roddy R, Jerin J, Young J, Byars L and Nutt R 2000 A combined PET/CT scanner for clinical oncology J. Nucl. Med. 41 1369-79
5. Bugaj J E, Achilefu S, Dorshow R B and Rajagopalan R 2001 Novel fluorescent contrast agents for optical imaging of in vivo tumors based on a receptor-targeted dye-peptide conjugate platform J. Biomed. Opt. 6 122-33
6. Celentano L, Laccetti P, Liuzzi R, Mettivier G, Montesi M C and Autiero M 2003 Preliminary tests of a prototype system for optical and radionuclide imaging in small animals IEEE Trans. Nucl. Sci. 50 1693-701
7. Contag C H, Contag P R, Mullins J I, Spilman S D, Stevenson D K and Benaron D A 1995 Photonic detection of bacterial pathogens in living hosts Mol. Microbiol. 18 593-603
8. Culver J, Akers W and Achilefu S 2008 Multimodality molecular imaging with combined optical and SPECT/PET modalities J. Nucl. Med. 49 169-72
9. Despres P, Barber W C, Funk T, McClish M, Shah K S and Hasegawa B H 2006 Investigation of a continuous crystal PSAPD-based gamma camera IEEE Trans. Nucl. Sci. 53 1643-9
10. Herbert D J, Meng L J and Ramsden D 2002 Investigating the energy resolution of arrays of small scintillation crystals IEEE Trans. Nucl. Sci. 49 931-6
11. Hong K J, Choi Y, Lee S C, Lee S Y, Song T Y, Min B J, Jung J H, Choe Y S, Lee K H and Kim B T 2006 A compact SPECT/CT system for small animal imaging IEEE Trans. Nucl. Sci. 53 2601-4
12. Jeong M H, Choi Y, Chung Y H, Song T Y, Jung J H, Hong K J, Min B J, Choe Y S, Lee K H and Kim B T 2004 Performance improvement of small animal camera using NaI(Tl) plate and position sensitive photo-multiplier tubes Phys. Med. Biol. 49 4961-70
13. Judenhofer M S et al 2008 Simultaneous PET/MRI: a new approach for functional and morphological imaging Nat. Med. 14 459-65
14. Kim J H, Choi Y, Joo K S, Sihn B S, Chong J W, Kim S E, Lee K H, Choe Y S and Kim B T 2000 Development of a miniature scintillation camera using an NaI(Tl) scintillator and PSPMT for scintimammography Phys. Med. Biol. 45 3481-8
15. Lewis J S, Achilefu S, Garbow J R, Laforest R and Welch M J 2002 Small animal imaging: current technology and perspectives for oncological imaging Eur. J. Cancer 38 2173-88
16. Li C, Wang W, Wu Q, Ke S, Houston J, Sevick-Muraca E, Dong L, Chow D, Charnsangavej C and Gelovani J 2006 Dual optical and nuclear imaging in human melanoma xenografts using a single targeted imaging probe Nucl. Med. Biol. 33 349-58
17. Pani R et al 2002 A compact gamma ray imager for oncology Nucl. Instrum. Methods Phys. Res. A 477 509-13
18. Pani R et al 2003 A novel compact gamma camera based on flat panel PMT Nucl. Instrum. Methods Phys. Res. A 513 36-41
19. Peter J and Semmler W 2007 vECTlab-a fully integrated multi-modality Monte Carlo simulation framework for the radiological imaging sciences Nucl. Instrum. Methods Phys. Res. A 580 955-9
20. Popov V, Majewski S and Welch B L 2006 A novel readout concept for multianode photomultiplier tubes with pad matrix anode layout Nucl. Instrum. Methods Phys. Res. A 567 319-22
21. Prout D L, Silverman R W and Chatziioannou A 2004 Detector concept for OPET-A combined PET and optical imaging system IEEE Trans. Nucl. Sci. 51 752-6
22. Prout D L, Silverman R W and Chatziioannou A 2005 Readout of the optical PET (OPET) detector IEEE Trans. Nucl. Sci. 52 28-32
23. Rice B W, Cable M D and Nelson M B 2001 In vivo imaging of light emitting probes J. Biomed. Opt. 6 432-40
24. Trotta C, Massari R, Palermo N, Scopinaro F and Soluri A 2007 New high spatial resolution portable camera in medical imaging Nucl. Instrum. Methods Phys. Res. A 577 604-10
25. Valentine J D, Moses W W, Derenzo S E, Wehe D K and Knoll G F 1993 Temperature dependence of CSl(TI) gamma-ray excited scintillation characteristics Nucl. Instrum. Methods Phys. Res. A 323 147-57
26. Verger L, Gentet M C, Gerfault L, Guillemaud R, Mestais C, Monnet O, Montemont G, Petroz G, Rostaing J P and Rustique J 2004 Performance and perspectives of a CdZnTe-based gamma camera for medical imaging IEEE Trans. Nucl. Sci. 51 3111-7
27. Wagnieres G A, Star W M and Wilson B C 1998 In vivo fluorescence spectroscopy and imaging for oncological applications Photochem. Photobiol. 68 603-32
28. Wojcik R, Majewski S, Kross B, Steinbach D and Weisenberger A G 1998 High spatial resolution gamma imaging detector based on a 5″ diameter R3292 Hamamatsu PSPMT IEEE Trans. Nucl. Sci. 45 487-91
29. Woody C L, Kierstead J A, Levy P W and Stoll S 1992 Radiation damage in undoped CsI and CsI(Tl) IEEE Trans. Nucl. Sci. 39 524-31
30. Zhang Z, Liang K, Bloch S, Berezin M and Achilefu S 2005 Monomolecular multimodal fluorescence-radioisotope imaging agents Bioconjug. Chem. 16 1232-9