Single and multiple mutations in the human cytomegalovirus UL97 gene and their relationship to the enzymatic activity of UL97 kinase for ganciclovir phosphorylation

Antiviral Research

Volumn 84, Issue 2, 2009, Pages 194-198

  Sanchez Puch, Silvia I ^a,b   Mathet, Verónica L ^a   Porta, Margarita ^b   Cuestas, María L ^a   Oubiña, José R ^a   Videla, Cristina M ^b   Salomón, Horacio E ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^b CEMIC   (Argentina)

Author keywords

GCV resistance; Human cytomegalovirus; MMT isolate; Polymorphism

Indexed keywords

ARGININE; ASPARAGINE; ASPARTIC ACID; CYSTEINE; GANCICLOVIR; GLUTAMIC ACID; ISOLEUCINE; LEUCINE; METHIONINE; PHENYLALANINE; PROLINE; PROTEIN KINASE; PROTEIN KINASE UL97; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANTIVIRAL RESISTANCE; ARTICLE; CONTROLLED STUDY; GENETIC POLYMORPHISM; HUMAN CYTOMEGALOVIRUS; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; NUCLEOTIDE SEQUENCE; PHOSPHORYLATION; POINT MUTATION; PRIORITY JOURNAL; STRAIN DIFFERENCE; VIRUS MUTATION;

ANTIVIRAL AGENTS; CELL LINE; CELLS, CULTURED; CYTOMEGALOVIRUS; DRUG RESISTANCE, VIRAL; FIBROBLASTS; GANCICLOVIR; HUMANS; IMMUNOCOMPROMISED HOST; MUTATION; PHOSPHORYLATION; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); POLYMORPHISM, GENETIC;

HUMAN HERPESVIRUS 5;

EID: 70349572867     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2009.08.005     Document Type: Article

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