Emergence of multiple human cytomegalovirus ganciclovir-resistant mutants with deletions and substitutions within the UL97 gene in a patient with severe combined immunodeficiency

Antimicrobial Agents and Chemotherapy

Volumn 45, Issue 2, 2001, Pages 593-595

  Wolf, D G ^a   Yaniv, I ^a   Ashkenazi, S ^a   Honigman, A ^a  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; GANCICLOVIR;

AMINO ACID SUBSTITUTION; ARTICLE; CODON; COMBINED IMMUNODEFICIENCY; GENE DELETION; HUMAN; HUMAN CYTOMEGALOVIRUS; NONHUMAN; PRIORITY JOURNAL; VIRUS MUTANT;

AMINO ACID SUBSTITUTION; ANTIVIRAL AGENTS; CYTOMEGALOVIRUS; DRUG RESISTANCE, MICROBIAL; FEMALE; GANCICLOVIR; GENE DELETION; GENES, BACTERIAL; HUMANS; INFANT; MUTATION; PLAQUE ASSAY; SEVERE COMBINED IMMUNODEFICIENCY;

EID: 0035141743     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.45.2.593-595.2001     Document Type: Article

References (23)

1. A three-nucleotide deletion in the UL97 open reading frame is responsible for the ganciclovir resistance of a human cytomegalovirus clinical isolate
2. The Cys607→Tyr change in the UL97 phosphotransferase confers ganciclovir resistance to two human cytomegalovirus strains recovered from two immunocompromised patients
3. Ganciclovir resistance as a result of oral ganciclovir in a heart transplant recipient with multiple human cytomegalovirus strains in blood
4. Alpha-, beta- and gammaherpesviruses encode a putative phosphotransferase
5. Analysis of interstrain variation in cytomegalovirus glycoprotein B sequences encoding neutralization-related epitopes
6. Analysis of the UL97 phosphotransferase coding sequence in clinical cytomegalovirus isolates and identification of mutations conferring ganciclovir resistance
7. Frequency of UL97 phosphotransferase mutations related to ganciclovir resistance in clinical cytomegalovirus isolates
8. A nine-codon deletion mutation in the cytomegalovirus UL97 phosphotransferase gene confers resistance to ganciclovir
9. Infections complicating congenital immunodeficiency syndromes
10. Ganciclovir
11. Novel mutation in the UL97 gene of a clinical cytomegalovirus strain conferring resistance to ganciclovir
12. The human cytomegalovirus UL97 protein is a protein kinase that autophosphorylates on serines and threonines
13. Emergence of ganciclovir-resistant cytomegalovirus disease among recipients of solid-organ transplants
14. Novel mutation in the CMV UL97 gene associated with resistance to ganciclovir therapy
15. Amino acids of conserved kinase motifs of cytomegalovirus protein UL97 are essential for autophosphorylation
16. A recombinant human cytomegalovirus with a large deletion in UL97 has a severe replication deficiency
17. Development of ganciclovir resistance during treatment of primary cytomegalovirus infection after liver transplantation
18. A protein kinase homologue controls phosphorylation of ganciclovir in human cytomegalovirus-infected cells
19. Acyclovir is phosphorylated by the human cytomegalovirus UL97 protein
20. Mutations in human cytomegalovirus UL97 gene confer clinical resistance to ganciclovir and can be detected directly in patient plasma
21. Early emergence of ganciclovir-resistant human cytomegalovirus strains in children with primary combined immunodeficiency
22. Inhibition of Epstein-Barr virus replication by a benzimidazole L-riboside: Novel antiviral mechanism of 5,6-dichloro-2-(isopropylamino)-1-β-L-ribofuranosyl-1H-benzimidazole