Design, synthesis, and biological evaluation of phenylpropanamides as novel transient receptor potential valnilloid 1 antagonists

Archives of Pharmacal Research

Volumn 32, Issue 9, 2009, Pages 1201-1210

  Li, Fu Nan ^a   Kim, Nam Jung ^a   Nam, Yeon Hee ^a   Kim, Seung Hee ^a   Seo, Seung Yong ^b   Jeong, Yeon Su ^c   Kim, Sun Young ^c   Park, Young Ho ^c   Suh, Young Ger ^a  

^a Seoul National University   (South Korea)

^b Woosuk University   (South Korea)

^c AmorePacific Corporation   (South Korea)

Author keywords

Amide; Analogues; Antagonists; Synthesis; TRPV1

Indexed keywords

3 (4 TERT BUTYLPHENYL) N [3 CHLORO 4 (METHYLSULFONAMIDO)BENZYL]PROPANAMIDE; ALKYL GROUP; AMINE; BENZYL DERIVATIVE; CALCIUM 45; ESTER DERIVATIVE; HALIDE; METHYL GROUP; NITRO DERIVATIVE; PHENYLPROPANAMIDE DERIVATIVE; PROPIONAMIDE DERIVATIVE; RECEPTOR BLOCKING AGENT; SULFONE DERIVATIVE; TRANSIENT RECEPTOR POTENTIAL CHANNEL 1; TRANSIENT RECEPTOR POTENTIAL VANILLOID 1 ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; DRUG DESIGN; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SYNTHESIS; IC 50; NEWBORN; NONHUMAN; RAT; RECEPTOR BLOCKING; SPINAL GANGLION; STRUCTURE ACTIVITY RELATION;

AMIDES; ANIMALS; CALCIUM; CELLS, CULTURED; DRUG DESIGN; GANGLIA, SPINAL; RATS; RATS, SPRAGUE-DAWLEY; TRPV CATION CHANNELS;

EID: 70349558224     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-009-1903-9     Document Type: Article

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