Anti-moesin antibodies derived from patients with aplastic anemia stimulate monocytic cells to secrete TNF-α through an ERK1/ 2-dependent pathway

International Immunology

Volumn 21, Issue 8, 2009, Pages 913-923

  Espinoza, J Luis ^a   Takamatsu, Hiroyuki ^a   Lu, Xuzhang ^a   Qi, Zhirong ^a   Nakao, Shinji ^a  

^a KANAZAWA UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCE   (Japan)

Author keywords

Aplastic anemia; Auto antibody; Moesin

Indexed keywords

CD14 ANTIGEN; CD40 ANTIGEN; CELL MEMBRANE PROTEIN; GLYCOPROTEIN P 15095; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN G ANTIBODY; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MOESIN ANTIBODY; PROTEIN ANTIBODY; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANTIBODY DETECTION; APLASTIC ANEMIA; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; IMMUNOCOMPETENT CELL; MONOCYTE; MONOCYTIC LEUKEMIA; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CROSS LINKING; PROTEIN EXPRESSION; PROTEIN INDUCTION;

ANEMIA, APLASTIC; ANTIBODY SPECIFICITY; AUTOANTIBODIES; CELLS, CULTURED; HUMANS; MICROFILAMENT PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASE 3; MONOCYTES; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 70349505773     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxp058     Document Type: Article

References (39)

1. Dubey, S., Shukla, P. and Nityanand, S. 2005. Expression of interferon-gamma and tumor necrosis factor-alpha in bone marrow T cells and their levels in bone marrow plasma in patients with aplastic anemia. Ann. Hematol. 84:572.
2. Young, N., Calado, R. and Scheinberg, P. 2006. Current concepts in the pathophysiology and treatment of aplastic anemia. Blood 108:2509.
3. Hirano, N., Butler, M., Von Bergwelt-Baildon, M. et al. 2003. Autoantibodies frequently detected in patients with aplastic anemia. Blood 102:4567.
4. Feng, X., Chuhjo, T., Sugimori, C. et al. 2004. Diazepam-binding inhibitor-related protein 1: A candidate autoantigen in acquired aplastic anemia patients harboring a minor population of paroxysmal nocturnal hemoglobinuria-type cells. Blood 104:2425.
5. Hirano, N., Butler, M., Guinan, E., Nadler, L. and Kojima, S. 2005. Presence of anti-kinectin and anti-PMS1 antibodies in Japanese aplastic anaemia patients. Br. J. Haematol. 128:221.
6. Takamatsu, H., Feng, X., Chuhjo, T. et al. 2007. Specific antibodies to moesin, a membrane-cytoskeleton linker protein, are frequently detected in patients with acquired aplastic anemia. Blood 109:2514.
7. Ariel, A., Hershkoviz, R., Altbaum-Weiss, I., Ganor, S. and Lider, O. 2001. Cell surface-expressed moesin-like receptor regulates T cell interactions with tissue components and binds an adhesion-modulating IL-2 peptide generated by elastase. J. Immunol. 166:3052.
8. Amar, S., Oyaisu, K., Li, L. and Van Dyke, T. 2001. Moesin: A potential LPS receptor on human monocytes. J. Endotoxin. Res. 7:281.
9. Iontcheva, I., Amar, S., Zawawi, K., Kantarci, A. and Van Dyke, T. 2004. Role for moesin in lipopolysaccharide-stimulated signal transduction. Infect. Immun. 72:2312.
10. Matsuyama, A., Sakai, N., Hiraoka, H., Hirano, K. and Yamashita, S. 2006. Cell surface-expressed moesin-like HDL/apoA-I binding protein promotes cholesterol efflux from human macrophages. J. Lipid Res. 47:78.
11. Takamatsu, H., Espinoza, J., Lu, X., Qi, Z., Okawa, K. and Nakao, S. 2009. Anti-moesin antibodies in the serum of patients with aplastic anemia stimulate peripheral blood mononuclear cells to secrete TNF-alpha and IFN-gamma. J. Immunol. 182:703.
12. Krawetz, R., MacKenzie, M., Sun, Q., Walton, P. and Kelly, G. 2006. Galpha13 activation rescues moesin-depletion induced apoptosis in F9 teratocarcinoma cells. Exp. Cell Res. 312:3224.
13. Adamczyk, M., Gebler, J. and Wu, J. 2000. Papain digestion of different mouse IgG subclasses as studied by electrospray mass spectrometry. J. Immunol. Methods 237:95.
14. Alderson, M., Armitage, R., Tough, T., Strockbine, L., Fanslow, W. and Spriggs, M. 1993. CD40 expression by human monocytes: Regulation by cytokines and activation of monocytes by the ligand for CD40. J. Exp. Med. 178:669.
15. Soler, M., Merant, C., Servant, C. et al. 1997. Leukosialin: (CD43) behavior during adhesion of human monocytic THP-1 cells to red blood cells. J. Leukoc. Biol. 61:609.
16. Reiling, N., Blumenthal, A., Flad, H., Ernst, M. and Ehlers, S. 2001. Mycobacteria-induced TNF-alpha and IL-10 formation by human macrophages is differentially regulated at the level of mitogen-activated protein kinase activity. J. Immunol. 167:3339.
17. Jung, S., Song, C., Yang, C. et al. 2005. Role of the phosphati-dylinositol 3-kinase and mitogen-activated protein kinase path-ways in the secretion of tumor necrosis factor-alpha and interleukin-10 by the PPD antigen of Mycobacterium tuberculosis. J. Clin. Immunol. 25:482.
18. Ivetic, A. and Ridley, A. 2004. Ezrin/radixin/moesin proteins and Rho GTPase signalling in leucocytes. Immunology 112:165.
19. Koss, M., Pfeiffer, G., Wang, Y., Thomas, S. et al. 2006. Ezrin/ radixin/moesin proteins are phosphorylated by TNF-alpha and modulate permeability increases in human pulmonary microvascular endothelial cells. J. Immunol. 176:1218.
20. Li, Y., Harada, T., Juang, Y. et al. 2007. Phosphorylated ERM is responsible for increased T cell polarization, adhesion, and migration in patients with systemic lupus erythematosus. J. Immunol. 178:1938.
21. Tsukita, S. and Yonemura, S. 1997. ERM (ezrin/radixin/moesin) family: from cytoskeleton to signal transduction. Curr. Opin. Cell Biol. 9:70.
22. Baroni, S., Santillo, M., Bevilacqua, F. et al. 2006. Stimulatory autoantibodies to the PDGF receptor in systemic sclerosis. N. Engl. J. Med. 354:2667.
23. AoYama, Y., Owada, M. and Kitajima, Y. 1999. A pathogenic autoantibody, pemphigus vulgaris-lgG, induces phosphorylation of desmoglein 3, and its dissociation from plakoglobin in cultured keratinocytes. Eur. J. Immunol. 29:2233.
24. Hughes, S. and Fehon, R. 2007. Understanding ERM proteins - the awesome power of genetics finally brought to bear. Curr. Opin. Cell Biol. 19:51.
25. Finnerty, C., Chambers, D., Ingraffea, J., Faber, H., Karplus, P. and Bretscher, A. 2004. The EBP50-moesin interaction involves a binding site regulated by direct masking on the FERM domain. J. Cell Sci. 117:1547.
26. Pearson, M., Reczek, D., Bretscher, A. and Karplus, P. 2000. Structure of the ERM protein moesin reveals the FERM domain fold masked by an extended actin binding tail domain. Cell 101:259.
27. Mori, T., Kitano, K., Terawaki, S., Maesaki, R. and Hakoshima, T. 2007. Crystallographic characterization of the radixin FERM domain bound to the cytoplasmic tail of adhesion molecule CD44. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 63:844.
28. Lankes, W. and Furthmayr, H. 1991. Moesin: A member of the protein 4. 1-talin-ezrin family of proteins. Proc. Natl Acad. Sci. USA 88:8297.
29. Lankes, W., Griesmacher, A., Grünwald, J., Schwartz-Albiez, R. and Keller, R. 1988. A heparin-binding protein involved in inhibition of smooth-muscle cell proliferation. Biochem. J. 251:831.
30. Urzainqui, A., Serrador, J., Viedma, F. et al. 2002. ITAM-based interaction of ERM proteins with Syk mediates signaling by the leukocyte adhesion receptor PSGL-1. Immunity 17:401.
31. Meers, S., Kasran, A., Boon, L. et al. 2007. Monocytes are activated in patients with myelodysplastic syndromes and can contribute to bone marrow failure through CD40-CD40L interactions with T helper cells. Leukemia 21:2411.
32. Uehara, A., Iwashiro, A., Sato, T., Yokota, S. and Takada, H. 2007. Antibodies to proteinase 3 prime human monocytic cells via protease-activated receptor-2 and NF-kappaB for Toll-like receptor- and NOD-dependent activation. Mol. Immunol. 44:3552.
33. Nowack, R., Schwalbe, K., Flores-Suárez, L., Yard, B. and van der Woude, F. 2000. Upregulation of CD14 and CD18 on monocytes In vitro by antineutrophil cytoplasmic autoantibodies. J. Am. Soc. Nephrol. 11:1639.
34. Belkina, N., Liu, Y., Hao, J., Karasuyama, H. and Shaw, S. 2009. LOK is a major ERM kinase in resting lymphocytes and regulates cytoskeletal rearrangement through ERM phosphorylation. Proc. Natl Acad. Sci. USA 106:4707.
35. Czuczman, M., Olejniczak, S., Gowda, A. et al. 2008. Acquirement of rituximab resistance in lymphoma cell lines is associated with both global CD20 gene and protein down-regulation regulated at the pretranscriptional and posttranscriptional levels. Clin. Cancer Res. 14:1561.
36. Weetman, A. 2003. Grave's disease 1835-2002. Horm. Res. 59 (Suppl 1):114.
37. Svegliati, S., Olivieri, A., Campelli, N. et al. 2007. Stimulatory autoantibodies to PDGF receptor in patients with extensive chronic graft-versus-host disease. Blood 110:237.
38. Yokota, S., Minota, S. and Fujii, N. 2006. Anti-HSP auto-antibodies enhance HSP-induced pro-inflammatory cytokine production in human monocytic cells via Toll-like receptors. Int. Immunol. 18:573.
39. Castro-Rueda, H. and Kavanaugh, A. 2008. Biologic therapy for early rheumatoid arthritis: The latest evidence. Curr. Opin. Rheumatol. 20:314.