Serum-free light chain analysis: works in progress

Clinical Chemistry and Laboratory Medicine

Volumn 47, Issue 9, 2009, Pages 1021-1022

  Merlini, Giampaolo ^a  

^a UNIVERSITY OF PAVIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN G; IMMUNOGLOBULIN LIGHT CHAIN;

AMYLOIDOSIS; BLOOD ANALYSIS; CANCER DIAGNOSIS; CAPILLARY ZONE ELECTROPHORESIS; DIAGNOSTIC ACCURACY; EDITORIAL; HOSPITAL; HUMAN; HYPERGAMMAGLOBULINEMIA; IMMUNOASSAY; IMMUNOGLOBULIN BLOOD LEVEL; KIDNEY BIOPSY; MONOCLONAL IMMUNOGLOBULINEMIA; MULTIPLE MYELOMA; PLASMA CELL DYSCRASIA; POLYMERIZATION; POPULATION; PRIORITY JOURNAL; PROGNOSIS; SCREENING;

BLOOD PROTEIN ELECTROPHORESIS; HUMANS; IMMUNOGLOBULIN KAPPA-CHAINS; IMMUNOGLOBULIN LAMBDA-CHAINS; MULTIPLE MYELOMA; PARAPROTEINEMIAS;

EID: 70349501467     PISSN: 14346621     EISSN: 14374331     Source Type: Journal    
DOI: 10.1515/CCLM.2009.265     Document Type: Editorial

References (16)

1. Bradwell AR, Carr-Smith HD, Mead GP, Tang LX, Showell PJ, Drayson MT, et al. Highly sensitive, automated immunoassay for immunoglobulin free light chains in serum and urine. Clin Chem 2001;47:673-680
2. Dispenzieri A, Kyle R, Merlini G, Miguel JS, Ludwig H, Hajek R, et al. International Myeloma Working Group guidelines for serum-free light chain analysis in multiple myeloma and related disorders. Leukemia 2009;23:215-224
3. Nakano T, Miyazaki S, Takahashi H, Matsumori A, Maruyama T, Komoda T, et al. Immunochemical quantification of free immunoglobulin light chains from an analytical perspective. Clin Chem Lab Med 2006;44:522-532
4. Robson E, Mead G, Bradwell A. To the editor: in reply to Nakano et al. Clin Chem Lab Med 2006;44:522-32.
5. Clin Chem Lab Med 2007;45:264-5; author reply 6-7.
6. Tate JR, Mollee P, Dimeski G, Carter AC, Gill D. Analytical performance of serum free light-chain assay during monitoring of patients with monoclonal light-chain diseases. Clin Chim Acta 2007;376:30-36
7. Robson E, Mead G, Carr-Smith H, Bradwell A. In reply to Tate, et al. Clin Chim Acta 2007;376:30-6.
8. Clin Chim Acta 2007;380:247; author reply 50-51
9. Katzmann JA, Dispenzieri A, Kyle RA, Snyder MR, Plevak MF, Larson DR, et al. Elimination of the need for urine studies in the screening algorithm for monoclonal gammopathies by using serum immunofixation and free light chain assays. Mayo Clin Proc 2006;81:1575-1578
10. Vermeersch P, Van Hoovels L, Delforge M, Marien G, Bossuyt X. Diagnostic performance of serum free light chain measurement in patients suspected of a monoclonal B-cell disorder. Br J Haematol 2008;143:496-502.
11. Palladini G, Russo P, Bosoni T, Verga L, Sarais G, Lavatelli F, et al. Identification of amyloidogenic light chains requires the combination of serum-free light chain assay with immunofixation of serum and urine. Clin Chem 2009;55:499-504.
12. Merlini G, Stone MJ. Dangerous small B-cell clones. Blood 2006;108:2520-2530
13. Durie BG, Harousseau JL, Miguel JS, Blade J, Barlogie B, Anderson K, et al. International uniform response criteria for multiple myeloma. Leukemia 2006;20:1467-1473
14. Singhal S, Vickrey E, Krishnamurthy J, Singh V, Allen S, Mehta J. The relationship between the serum free light chain assay and serum immunofixation electrophoresis, and the definition of concordant and discordant free light chain ratios. Blood 2009;114:38-39
15. Sthaneshwar P, Nadarajan V, Maniam JA, Nordin N, Gin GG. Serum free light chains: diagnostic and prognostic value in multiple myeloma. Clin Chem Lab Med 2009;47: 1101-1107
16. Böer K, Deufel T. Quantitation of serum free light chains does not compensate for serum immunofixation only when screening for monoclonal gammopathies. Clin Chem Lab Med 2009;47:1109-1115